N.O. Concha

4.9k citations

31 papers · 4.2k · 1 hit paper · h-index 23

Impact in

Molecular Medicine top 1%
- Antibiotic Resistance in Bacteria
Immunology top 5%
- interferon and immune responses
- Immunotherapy and Immune Responses

Papers in

Molecular Biology 17
- PI3K/AKT/mTOR signaling in cancer 4
- S100 Proteins and Annexins 3
- Protein Kinase Regulation and GTPase Signaling 3
- Cell death mechanisms and regulation 3
- Epigenetics and DNA Methylation 2
Molecular Medicine 4
- Antibiotic Resistance in Bacteria 4

Co-authors: John R. Dedman (3 shared papers)Barbara A. Seaton (3 shared papers)Beth A. Rasmussen (2 shared papers)Karen Bush (2 shared papers)Osnat Herzberg (2 shared papers)Marcia A. Kaetzel (2 shared papers)Manal A. Swairjo (1 shared paper)J. W. Head (2 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (4 papers)Biochemistry (4 papers)Journal of Medicinal Chemistry (3 papers)PLoS ONE (2 papers)Cancer Cell (2 papers)
Partner nations: United States United Kingdom Germany

In The Last Decade

N.O. Concha

31 papers receiving 4k citations

N.O. Concha's Hit Papers

align trajectories log scale

Design of amidobenzimidazole STING receptor agonists with systemic activity 2018 · 735 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2018 Nature

Peers

Countries citing papers authored by N.O. Concha

Since Specialization

Citations

This map shows the geographic impact of N.O. Concha's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by N.O. Concha with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites N.O. Concha more than expected).

Fields of papers citing papers by N.O. Concha

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by N.O. Concha. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by N.O. Concha. The network helps show where N.O. Concha may publish in the future.

Co-authors

The 25 scholars most cited alongside N.O. Concha, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with N.O. Concha Line = papers co-authored together N.O. Concha links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 31 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Design of amidobenzimidazole STING receptor agonists with systemic activity Nature ·Joshi M. Ramanjulu, G. Scott Pesiridis, Jingsong Yang, N.O. Concha, Robert R. Singhaus, Shuyun Zhang, Jean-Luc Tran, Patrick Moore Hit paper breakdown →	2018	735
2	A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC Cancer Cell ·Helai P. Mohammad, Kimberly N. Smitheman, Chandrashekhar D. Kamat, David Soong, Kelly Federowicz, Glenn S. Van Aller, Jess Schneck, Jeffrey D. Carson	2015	425
3	Crystal structure of the wide-spectrum binuclear zinc β-lactamase from Bacteroides fragilis Structure ·N.O. Concha, Beth A. Rasmussen, Karen Bush, Osnat Herzberg	1996	317
4	Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor, Biochemistry ·N.O. Concha, Cheryl A. Janson, P. Rowling, Stewart C. Pearson, C.A. Cheever, Brian P. Clarke, Ceri J. Lewis, Moreno Galleni	2000	281
5	Ca2+-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V Nature Structural & Molecular Biology ·Manal A. Swairjo, N.O. Concha, Marcia A. Kaetzel, John R. Dedman, Barbara A. Seaton	1995	261
6	Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss Cancer Cell ·Andrew Fedoriw, Satyajit Rajapurkar, Shane W. O’Brien, Sarah V. Gerhart, Lorna H. Mitchell, Nicholas D. Adams, Nathalie Rioux-Leclerq, Trupti Lingaraj	2019	251
7	Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO PLoS ONE ·Anne Cleasby, Jeff R. Yon, Caroline J. Richardson, Ian J. Tickle, Pamela A. Williams, James F. Callahan, Robin A. E. Carr, N.O. Concha	2014	233
8	Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality Journal of Biological Chemistry ·Dennis M. Lee, Scott A. Long, Jerry L. Adams, Kalindi S. Vaidya, Terry A. Francis, Kristine K. Kikly, James D. Winkler, Chiu-Mei Sung	2000	214
9	Structural Basis for Chk1 Inhibition by UCN-01 Journal of Biological Chemistry ·Baoguang Zhao, Michael J. Bower, Patrick J. McDevitt, Huizhen Zhao, Kyung Johanson, Susan M. Green, N.O. Concha, Bin‐Bing S. Zhou +1 other	2002	181
10	Rat Annexin V Crystal Structure: Ca 2+ -Induced Conformational Changes Science ·N.O. Concha, J. W. Head, M. A. Kaetzel, John R. Dedman, Barbara A. Seaton	1993	167
11	New IDH1 mutant inhibitors for treatment of acute myeloid leukemia Nature Chemical Biology ·Ujunwa Cynthia Okoye-Okafor, Boris Bartholdy, Jessy Cartier, Enoch N. Gao, Beth Pietrak, Alan R. Rendina, Cynthia M. Rominger, Chad J. Quinn	2015	157
12	3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Journal of Medicinal Chemistry ·Rosanna Tedesco, Antony N. Shaw, Ramesh B. Bambal, Deping Chai, N.O. Concha, Michael G. Darcy, Dashyant Dhanak, Duke M. Fitch	2006	153
13	Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase Journal of Medicinal Chemistry ·Dirk A. Heerding, Nelson Rhodes, Jack D. Leber, Tammy J. Clark, Richard M. Keenan, Louis V. LaFrance, Mei Li, Igor G. Safonov	2008	136
14	A Tale of Two Subunits: How the Neomorphic R132H IDH1 Mutation Enhances Production of αHG Biochemistry ·Beth Pietrak, Huizhen Zhao, Hongwei Qi, Chad J. Quinn, Enoch N. Gao, N.O. Concha, Kristin Brown, Chaya Duraiswami	2011	99
15	Annexin V forms calcium‐dependent trimeric units on phospholipid vesicles FEBS Letters ·N.O. Concha, J. W. Head, Marcia A. Kaetzel, John R. Dedman, Barbara A. Seaton	1992	91
16	Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases Antimicrobial Agents and Chemotherapy ·David J Payne, Juan A. Hueso-Rodríguez, Helen Boyd, N.O. Concha, Cheryl A. Janson, Martin L. Gilpin, John H. Bateson, C.A. Cheever	2002	91
17	Mutant IDH1 Enhances the Production of 2-Hydroxyglutarate Due to Its Kinetic Mechanism Biochemistry ·Alan R. Rendina, Beth Pietrak, Angela M. Smallwood, Huizhen Zhao, Hongwei Qi, Chad J. Quinn, Nicholas D. Adams, N.O. Concha	2013	72
18	Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity Molecular Pharmacology ·N.O. Concha, Angela M. Smallwood, William G. Bonnette, Rachel D. Totoritis, Kelly Federowicz, Jingsong Yang, Hongwei Qi, Stephanie Chen	2015	46
19	Crystal structures of the cadmium‐ and mercury‐substituted metallo‐β‐lactamase from Bacteroides fragilis Protein Science ·N.O. Concha, Osnat Herzberg, Beth A. Rasmussen, Karen Bush	1997	41
20	Controlling Apoptosis by Inhibition of Caspases Current Medicinal Chemistry ·N.O. Concha, S. Abdel‐Meguid	2002	41

About N.O. Concha

N.O. Concha is a scholar working on Molecular Biology, Molecular Medicine, Biochemistry, Hepatology and Hematology, having authored 31 papers that have together received 4.2k indexed citations. Recurring topics across this work include PI3K/AKT/mTOR signaling in cancer (4 papers), Antibiotic Resistance in Bacteria (4 papers), S100 Proteins and Annexins (3 papers), Protein Kinase Regulation and GTPase Signaling (3 papers), Cell death mechanisms and regulation (3 papers), Cancer, Hypoxia, and Metabolism (2 papers), Epigenetics and DNA Methylation (2 papers) and Hepatitis C virus research (2 papers). The work is most often cited by research in Molecular Medicine (527 citations), Immunology (599 citations), Molecular Biology (1.8k citations), Genetics (145 citations) and Cancer Research (215 citations). N.O. Concha has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include John R. Dedman, Barbara A. Seaton, Beth A. Rasmussen, Karen Bush, Osnat Herzberg, Marcia A. Kaetzel, Manal A. Swairjo, J. W. Head, Hongwei Qi and M. A. Kaetzel. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Biochemistry, Journal of Medicinal Chemistry, PLoS ONE and Cancer Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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N.O. Concha's Hit Papers

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