Marc Ruff

6.3k citations

74 papers · 5.2k · 2 hit papers · h-index 28

Impact in

Virology top 2%
- HIV Research and Treatment
Genetics top 1%
- Estrogen and related hormone effects

Papers in

Virology 20
- HIV Research and Treatment 18
Infectious Diseases 24
- HIV/AIDS drug development and treatment 22

Co-authors: Dino Moras (32 shared papers)Hinrich Gronemeyer (4 shared papers)Pierre Chambon (4 shared papers)William Bourguet (3 shared papers)Natacha Rochel (4 shared papers)Jean‐Paul Renaud (2 shared papers)B. Rees (4 shared papers)V Vivat (1 shared paper)
Journals: Retrovirology (9 papers)Nucleic Acids Research (3 papers)Journal of Biological Chemistry (3 papers)Protein Expression and Purification (3 papers)Nature (3 papers)
Partner nations: France United States Switzerland

In The Last Decade

Marc Ruff

71 papers receiving 5.0k citations

Marc Ruff's Hit Papers

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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α 1995 · 1.0k citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

1995 Nature
1995 Nature

Peers

Countries citing papers authored by Marc Ruff

Since Specialization

Citations

This map shows the geographic impact of Marc Ruff's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Marc Ruff with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Marc Ruff more than expected).

Fields of papers citing papers by Marc Ruff

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Marc Ruff. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Marc Ruff. The network helps show where Marc Ruff may publish in the future.

Co-authors

The 25 scholars most cited alongside Marc Ruff, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Marc Ruff Line = papers co-authored together Marc Ruff links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 74 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α Nature ·William Bourguet, Marc Ruff, Pierre Chambon, Hinrich Gronemeyer, Dino Moras Hit paper breakdown →	1995	1036
2	Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid Nature ·Jean‐Paul Renaud, Natacha Rochel, Marc Ruff, V Vivat, Pierre Chambon, Hinrich Gronemeyer, Dino Moras Hit paper breakdown →	1995	962
3	Class II Aminoacyl Transfer Rna Synthetases: Crystal Structure of Yeast Aspartyl-trna Synthetase Complexed with tRNA Asp Science ·Marc Ruff, Sriram Krishnaswamy, Marcel Boeglin, Arnaud Poterszman, A. Mitschler, ALBERTO D. PODJARNY, B. Rees, J. C. Thierry	1991	581
4	HSPA8/HSC70 chaperone protein Autophagy ·François Stricher, Christophe F. Macri, Marc Ruff, Sylviane Muller	2013	318
5	Yeast tRNAAsp recognition by its cognate class II aminoacyl-tRNA synthetase Nature ·J. Cavarelli, B. Rees, Marc Ruff, Jean‐Claude Thierry, Dino Moras	1993	254
6	The active site of yeast aspartyl‐tRNA synthetase: structural and functional aspects of the aminoacylation reaction. The EMBO Journal ·J. Cavarelli, Gilbert Eriani, B. Rees, Marc Ruff, Marcel Boeglin, A. Mitschler, Franck Martin, Jean Gangloff	1994	224
7	Crystal Structure of a Mutant hERα Ligand-binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism Journal of Biological Chemistry ·Monique Gangloff, Marc Ruff, Sylvia Eiler, Sylvie Duclaud, Jean‐Marie Wurtz, Dino Moras	2001	126
8	Human TAFII28 and TAFII18 Interact through a Histone Fold Encoded by Atypical Evolutionary Conserved Motifs Also Found in the SPT3 Family Cell ·Catherine Birck, Olivier Poch, Christophe Romier, Marc Ruff, Gabrielle Mengus, Anne-Claire Lavigne, Irwin Davidson, Dino Moras	1998	120
9	Estrogen receptor transcription and transactivation Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors Breast Cancer Research ·Marc Ruff, Monique Gangloff, Jean‐Marie Wurtz, Dino Moras	2000	117
10	Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage Retrovirology ·Erwann Le Rouzic, Damien Bonnard, Sophie Chasset, Jean‐Michel Bruneau, Francis Chevreuil, Frédéric Le Strat, Juliette Nguyen, Roxane Beauvoir	2013	110
11	HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates Cells ·Srinivasa Reddy Bonam, Marc Ruff, Sylviane Muller	2019	102
12	Binding of Estrogenic Compounds to Recombinant Estrogen Receptor-α: Application to Environmental Analysis Environmental Health Perspectives ·Arnaud Pillon, Anne‐Marie Boussioux, Aurélie Escande, Sélim Aı̈t-Aı̈ssa, Elena Góméz, Hélène Fenet, Marc Ruff, Dino Moras	2004	94
13	Overexpression, Purification, and Crystal Structure of Native ERα LBD Protein Expression and Purification ·Sylvia Eiler, Monique Gangloff, Sylvie Duclaud, Dino Moras, Marc Ruff	2001	82
14	Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactor The EMBO Journal ·Fabrice Michel, Corinne Crucifix, Florence Granger, Sylvia Eiler, Jean‐François Mouscadet, Sergei V. Korolev, Julia Agapkina, Rustam Ziganshin	2009	81
15	Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors Proceedings of the National Academy of Sciences ·Judit Ősz, Yann Brélivet, Carole Peluso‐Iltis, Vincent Cura, Sylvia Eiler, Marc Ruff, William Bourguet, Natacha Rochel	2012	66
16	The impact of protein characterization in structural proteomics Acta Crystallographica Section D Biological Crystallography ·Arie Geerlof, James Ben Brown, Bruno Coutard, Marie Pierre Egloff, Francisco J. Enguita, Mark J. Fogg, Robert J.C. Gilbert, Matthew R. Groves	2006	54
17	Dynamics of Methylated Cytosine Flipping by UHRF1 Journal of the American Chemical Society ·Vasyl Kilin, Krishna Gavvala, Nicolas P. F. Barthes, Benoît Y. Michel, Dongwon Shin, Christian Boudier, Olivier Mauffret, Valeriy M.N. Yashchuk	2017	48
18	A high resolution diffracting crystal form of the complex between yeast tRNAAsp and aspartyl-tRNA synthetase Journal of Molecular Biology ·Marc Ruff, A. Mitschler, J. Cavarelli, R. Giegé, Vincent Mikol, J. C. Thierry, Bernard Lorber, Dino Moras	1988	47
19	Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design Journal of Medicinal Chemistry ·Nicolas Lévy, Jean‐Michel Bruneau, Erwann Le Rouzic, Damien Bonnard, Frédéric Le Strat, Audrey Caravano, Francis Chevreuil, Julien Barbion	2019	44
20	Preliminary X-ray investigation of 70 S ribosome crystals from Thermus thermophilus Journal of Molecular Biology ·Sergei D. Trakhanov, Marat Yusupov, В. Б. Широков, Marina B. Garber, A. Mitschler, Marc Ruff, Jean‐Claude Thierry, Dino Moras	1989	41

About Marc Ruff

Marc Ruff is a scholar working on Virology, Infectious Diseases, Molecular Biology, Genetics and Cell Biology, having authored 74 papers that have together received 5.2k indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (22 papers), HIV Research and Treatment (18 papers), Estrogen and related hormone effects (13 papers), RNA modifications and cancer (12 papers), Enzyme Structure and Function (12 papers), RNA and protein synthesis mechanisms (10 papers), Biochemical and Molecular Research (8 papers) and Cytomegalovirus and herpesvirus research (6 papers). The work is most often cited by research in Virology (383 citations), Genetics (2.1k citations), Molecular Biology (3.8k citations), Toxicology (117 citations) and Biochemistry (169 citations). Marc Ruff has collaborated with scholars based in France, United States and Switzerland. Frequent co-authors include Dino Moras, Hinrich Gronemeyer, Pierre Chambon, William Bourguet, Natacha Rochel, Jean‐Paul Renaud, B. Rees, V Vivat, Sylviane Muller and A. Mitschler. Their work appears in journals such as Retrovirology, Nucleic Acids Research, Journal of Biological Chemistry, Protein Expression and Purification and Nature.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Marc Ruff's Hit Papers

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