Len Stephens

22.7k citations

166 papers · 19.6k · 3 hit papers · h-index 70

Impact in

Molecular Biology top 0.2%
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
Cell Biology top 0.2%
- Cellular transport and secretion
- Cellular Mechanics and Interactions

Papers in

Molecular Biology 128
- Protein Kinase Regulation and GTPase Signaling 75
- PI3K/AKT/mTOR signaling in cancer 58
- Sphingolipid Metabolism and Signaling 9
- Metabolism, Diabetes, and Cancer 7
Biochemistry 20
- Lipid metabolism and biosynthesis 20

Co-authors: Phillip T. Hawkins (134 shared papers)Karen E. Anderson (43 shared papers)Trevor Jackson (12 shared papers)Olga Perišić (7 shared papers)Edward H. Walker (3 shared papers)Bart Vanhaesebroeck (3 shared papers)Keith Davidson (14 shared papers)John Coadwell (8 shared papers)
Journals: Biochemical Journal (18 papers)Current Biology (11 papers)Journal of Biological Chemistry (8 papers)The EMBO Journal (7 papers)Nature (6 papers)
Partner nations: United Kingdom United States France

In The Last Decade

Len Stephens

165 papers receiving 19k citations

Len Stephens's Hit Papers

align trajectories log scale

PI3K signalling: the path to discovery and understanding 2012 · 813 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2012 Nature Reviews Molecular Cell Biology
2000 Molecular Cell
1998 Science

Peers

Countries citing papers authored by Len Stephens

Since Specialization

Citations

This map shows the geographic impact of Len Stephens's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Len Stephens with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Len Stephens more than expected).

Fields of papers citing papers by Len Stephens

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Len Stephens. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Len Stephens. The network helps show where Len Stephens may publish in the future.

Co-authors

The 25 scholars most cited alongside Len Stephens, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Len Stephens Line = papers co-authored together Len Stephens links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 166 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine Molecular Cell ·Edward H. Walker, Michael E. Pacold, Olga Perišić, Len Stephens, Phillip T. Hawkins, Matthias P. Wymann +1 other Hit paper breakdown →	2000	1075
2	Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B Science ·Len Stephens, Karen E. Anderson, David Stokoe, Hediye Erdjument‐Bromage, Gavin F. Painter, Andrew B. Holmes, Piers R. J. Gaffney, Colin B. Reese Hit paper breakdown →	1998	928
3	PI3K signalling: the path to discovery and understanding Nature Reviews Molecular Cell Biology ·Bart Vanhaesebroeck, Len Stephens, Phillip T. Hawkins Hit paper breakdown →	2012	813
4	Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ Cell ·Michael E. Pacold, Sabine Suire, Olga Perišić, Samuel Lara‐González, Colin T. Davis, Edward H. Walker, Phillip T. Hawkins, Len Stephens	2000	537
5	A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits Cell ·Len Stephens, Alan V. Smrcka, Frank T. Cooke, Trevor Jackson, Paul C. Sternweis, Phillip T. Hawkins	1994	533
6	Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage Science ·Oscar Vadas, Fabien Garçon, Edward Banham-Hall, Vincent Plagnol, Timothy Ronan Leahy, Helen Baxendale, Tanya I. Coulter, James W. Curtis	2013	511
7	The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101 Cell ·Len Stephens, A. Eguinoa, Hediye Erdjument‐Bromage, Michelle L. Lui, Frank T. Cooke, John Coadwell, Alan Smrcka, Marcus Thelen	1997	493
8	PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase Current Biology ·Phillip T. Hawkins, A. Eguinoa, Rongguo Qiu, David Stokoe, Frank T. Cooke, Rhodri J. Walters, Stefan Wennström, Lena Claesson	1995	487
9	Signalling through Class I PI3Ks in mammalian cells Biochemical Society Transactions ·Phillip T. Hawkins, Karen E. Anderson, Keith Davidson, Len Stephens	2006	472
10	PI3K signalling in inflammation Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids ·Phillip T. Hawkins, Len Stephens	2014	455
11	P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac Cell ·Heidi C. E. Welch, W. John Coadwell, Christian D. Ellson, Simon Andrews, Hediye Erdjument‐Bromage, Paul Tempst, Phillip T. Hawkins, Len Stephens +1 other	2002	429
12	Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils Nature ·Len Stephens, Kelly T. Hughes, Robin F. Irvine	1991	427
13	Structural insights into phosphoinositide 3-kinase catalysis and signalling Nature ·Edward H. Walker, Olga Perišić, Len Stephens +2 others	1999	426
14	Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Len Stephens, Trevor Jackson, Phillip T. Hawkins	1993	405
15	Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling Current Biology ·Stefan Wennström, Phillip T. Hawkins, Frank T. Cooke, Kenta Hara, Kazuyoshi Yonezawa, Masato Kasuga, Trevor Jackson, Lena Claesson	1994	400
16	1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proceedings of the National Academy of Sciences ·Kenta Hara, Kazuyoshi Yonezawa, Hiroshi Sakaue, Akifumi Ando, Ko Kotani, Tadahiro Kitamura, Yukari Kitamura, Len Stephens	1994	397
17	Activation of the small GTP-binding proteins rho and rac by growth factor receptors Journal of Cell Science ·Catherine D. Nobes, Phillip T. Hawkins, Len Stephens, Alan K. Hall	1995	393
18	PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox Nature Cell Biology ·Chris D. Ellson, Stéphanie Gobert, Karen E. Anderson, Keith Davidson, Hediye Erdjument‐Bromage, Paul Tempst, Jan Willem Thuring, Matthew A. Cooper	2001	358
19	Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B Current Biology ·Karen E. Anderson, John Coadwell, Len Stephens, Phillip T. Hawkins	1998	305
20	Phosphoinositide 3‐kinase‐dependent activation of Rac FEBS Letters ·Heidi C. E. Welch, W. John Coadwell, Len Stephens, Phillip T. Hawkins	2003	279

About Len Stephens

Len Stephens is a scholar working on Molecular Biology, Biochemistry, Immunology, Cell Biology and Physiology, having authored 166 papers that have together received 19.6k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (75 papers), PI3K/AKT/mTOR signaling in cancer (58 papers), Neutrophil, Myeloperoxidase and Oxidative Mechanisms (22 papers), Lipid metabolism and biosynthesis (20 papers), Cellular transport and secretion (15 papers), Sphingolipid Metabolism and Signaling (9 papers), Metabolism, Diabetes, and Cancer (7 papers) and Calcium signaling and nucleotide metabolism (6 papers). The work is most often cited by research in Molecular Biology (11.8k citations), Cell Biology (2.4k citations), Physiology (567 citations), Immunology (2.7k citations) and Biochemistry (711 citations). Len Stephens has collaborated with scholars based in United Kingdom, United States and France. Frequent co-authors include Phillip T. Hawkins, Karen E. Anderson, Trevor Jackson, Olga Perišić, Edward H. Walker, Bart Vanhaesebroeck, Keith Davidson, John Coadwell, Robin F. Irvine and Frank T. Cooke. Their work appears in journals such as Biochemical Journal, Current Biology, Journal of Biological Chemistry, The EMBO Journal and Nature.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Len Stephens's Hit Papers

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About Len Stephens

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