John C. Castle

14.0k citations

56 papers · 10.1k · 4 hit papers · h-index 34

Impact in

Cancer Research top 0.2%
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
Molecular Biology top 0.5%
- RNA Research and Splicing
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery

Papers in

Molecular Biology 32
- RNA modifications and cancer 11
- RNA Research and Splicing 8
- RNA and protein synthesis mechanisms 8
Cancer Research 9
- Cancer-related molecular mechanisms research 4

Co-authors: Jason M. Johnson (21 shared papers)Philip W. Garrett-Engele (6 shared papers)Peter S. Linsley (2 shared papers)Lee P. Lim (1 shared paper)David P. Bartel (1 shared paper)Nelson C. Lau (1 shared paper)Janell M. Schelter (1 shared paper)Andrew Grimson (1 shared paper)
Journals: Journal of Geophysical Research Atmospheres (5 papers)PLoS ONE (5 papers)BMC Genomics (3 papers)Proceedings of the National Academy of Sciences (2 papers)Bioinformatics (2 papers)
Partner nations: United States Germany United Kingdom

In The Last Decade

John C. Castle

55 papers receiving 10.0k citations

John C. Castle's Hit Papers

align trajectories log scale

Exploiting the Mutanome for Tumor Vaccination 2012 · 625 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2012 Cancer Research
2005 Nature
2005 Nature Genetics
2003 Science

Peers

Countries citing papers authored by John C. Castle

Since Specialization

Citations

This map shows the geographic impact of John C. Castle's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John C. Castle with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John C. Castle more than expected).

Fields of papers citing papers by John C. Castle

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John C. Castle. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John C. Castle. The network helps show where John C. Castle may publish in the future.

Co-authors

The 25 scholars most cited alongside John C. Castle, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John C. Castle Line = papers co-authored together John C. Castle links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 56 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs Nature ·Lee P. Lim, Nelson C. Lau, Philip W. Garrett-Engele, Andrew Grimson, Janell M. Schelter, John C. Castle, David P. Bartel, Peter S. Linsley, Jason M. Johnson Hit paper breakdown →	2005	3920
2	Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays Science ·Jason M. Johnson, John C. Castle, Philip W. Garrett-Engele, Zhengyan Kan, Patrick Loerch, Christopher D. Armour, Ralph Santos, Eric E. Schadt, Roland Stoughton, Daniel Shoemaker Hit paper breakdown →	2003	1116
3	An integrative genomics approach to infer causal associations between gene expression and disease Nature Genetics ·Eric E. Schadt, John R. Lamb, Xia Yang, Jun Zhu, (unknown), Debraj GuhaThakurta, Solveig K. Sieberts, Stephanie A. Monks, Marc L. Reitman, Chunsheng Zhang, Pek Yee Lum, Amy Leonardson, Rolf Thieringer, Joseph M. Metzger, Liming Yang, John C. Castle, Haoyuan Zhu, Shera Kash, Thomas A. Drake, Alan B. Sachs, Aldons J. Lusis Hit paper breakdown →	2005	741
4	Exploiting the Mutanome for Tumor Vaccination Cancer Research ·John C. Castle, Sebastian Kreiter, Jan Diekmann, Martin Löwer, Niels van de Roemer, Jos de Graaf, Abderraouf Selmi, Mustafa Diken, Sebastian Boegel, Claudia Paret, Michael Koslowski, Andreas N. Kuhn, Cedrik M. Britten, Christoph Huber, Özlem Türeci, Uğur Şahin Hit paper breakdown →	2012	625
5	A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart Proceedings of the National Academy of Sciences ·Auinash Kalsotra, Xinshu Xiao, Amanda J. Ward, John C. Castle, Jason M. Johnson, Christopher B. Burge, Thomas A. Cooper	2008	408
6	Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2 Proceedings of the National Academy of Sciences ·Juan I. Young, Eugene P. Hong, John C. Castle, Juan Crespo-Barreto, Aaron B. Bowman, Matthew F. Rose, Dongcheul Kang, Ron Richman, Jason M. Johnson, Susan M. Berget, Huda Y. Zoghbi	2005	377
7	Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines Nature Genetics ·John C. Castle, Chaolin Zhang, Jyoti Shah, Amit Kulkarni, Auinash Kalsotra, Thomas A. Cooper, Jason M. Johnson	2008	245
8	Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2 Genes & Development ·Chaolin Zhang, Zuo‐Feng Zhang, John C. Castle, Shuying Sun, Jason M. Johnson, Adrian R. Krainer, Michael Q. Zhang	2008	244
9	Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition Xenobiotica ·Kelly Bleasby, John C. Castle, C. J. Roberts, Chunzhen Cheng, Wendy J. Bailey, Joseph F. Sina, Amit Kulkarni, Mike Hafey, Raymond Evers, Jason M. Johnson, Roger G. Ulrich, J. Greg Slatter	2006	217
10	Unique Signatures of Long Noncoding RNA Expression in Response to Virus Infection and Altered Innate Immune Signaling mBio ·Xinxia Peng, Lisa E. Gralinski, Christopher D. Armour, Martin T. Ferris, Matthew J. Thomas, Sean Proll, Birgit Bradel-Tretheway, Marcus J. Korth, John C. Castle, Matthew C. Biery, Heather Bouzek, David R. Haynor, Matthew B. Frieman, Mark T. Heise, Christopher K. Raymond, Ralph S. Baric, Michael G. Katze	2010	215
11	Digital transcriptome profiling using selective hexamer priming for cDNA synthesis Nature Methods ·Christopher D. Armour, John C. Castle, Ronghua Chen, Tomas Babak, Patrick Loerch, Stuart D. Jackson, Jyoti Shah, John Dey, Carol A. Rohl, Jason M. Johnson, Christopher K. Raymond	2009	127
12	RNA-Seq Atlas—a reference database for gene expression profiling in normal tissue by next-generation sequencing Bioinformatics ·M Krupp, Jens U. Marquardt, Uğur Şahin, Peter R. Galle, John C. Castle, Andreas Teufel	2012	122
13	Global regulation of alternative splicing during myogenic differentiation Nucleic Acids Research ·Christopher S. Bland, Eric T. Wang, Anthony Q. Vu, Marjorie David, John C. Castle, Jason M. Johnson, Christopher B. Burge, Thomas A. Cooper	2010	121
14	Definition, conservation and epigenetics of housekeeping and tissue-enriched genes BMC Genomics ·Xinwei She, Carol A. Rohl, John C. Castle, Amit Kulkarni, Jason M. Johnson, Ronghua Chen	2009	120
15	Individual-specific variation of gene expression in peripheral blood leukocytes Genomics ·Jerald P. Radich, Mao Mao, S. Stepaniants, Matthew C. Biery, John C. Castle, Terry Ward, Greg Schimmack, Sumire Kobayashi, Michael Carleton, Johanna W. Lampe, Peter S. Linsley	2004	106
16	Expression of Alternatively Spliced Sodium Channel α-Subunit Genes Journal of Biological Chemistry ·Christopher K. Raymond, John C. Castle, Philip W. Garrett-Engele, Christopher D. Armour, Zhengyan Kan, Nicholas F. Tsinoremas, Jason M. Johnson	2004	101
17	Digital Genome-Wide ncRNA Expression, Including SnoRNAs, across 11 Human Tissues Using PolyA-Neutral Amplification PLoS ONE ·John C. Castle, Christopher D. Armour, Martin Löwer, David R. Haynor, Matthew C. Biery, Heather Bouzek, Ronghua Chen, Stuart D. Jackson, Jason M. Johnson, Carol A. Rohl, Christopher K. Raymond	2010	94
18	Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals Gene ·Özlem Türeci, Michael Koslowski, Gerd Helftenbein, John C. Castle, Christoph Rohde, Karl Dhaene, Gerhard Seitz, Uğur Şahin	2011	89
19	PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling eLife ·Stefania Monterisi, Miguel J. Lobo, Craig Livie, John C. Castle, Michael Weinberger, George S. Baillie, Nicoletta C. Surdo, Nshunge Musheshe, Alessandra Stangherlin, Eyal Gottlieb, Rory J. Maizels, Mario Bortolozzi, Massimo Micaroni, Manuela Zaccolo	2017	82
20	Pathway and gene-set activation measurement from mRNA expression data: the tissue distribution of human pathways Genome biology ·David Levine, David R. Haynor, John C. Castle, S. Stepaniants, Matteo Pellegrini, Mao Mao, Jason M. Johnson	2006	82

About John C. Castle

John C. Castle is a scholar working on Molecular Biology, Cancer Research, Geophysics, Genetics and Epidemiology, having authored 56 papers that have together received 10.1k indexed citations. Recurring topics across this work include RNA modifications and cancer (11 papers), earthquake and tectonic studies (8 papers), RNA Research and Splicing (8 papers), Geological and Geochemical Analysis (8 papers), RNA and protein synthesis mechanisms (8 papers), High-pressure geophysics and materials (8 papers), Cancer-related molecular mechanisms research (4 papers) and Monoclonal and Polyclonal Antibodies Research (3 papers). The work is most often cited by research in Cancer Research (3.5k citations), Molecular Biology (7.0k citations), Immunology (1.1k citations), Aging (71 citations) and Genetics (1.1k citations). John C. Castle has collaborated with scholars based in United States, Germany and United Kingdom. Frequent co-authors include Jason M. Johnson, Philip W. Garrett-Engele, Peter S. Linsley, Lee P. Lim, David P. Bartel, Nelson C. Lau, Janell M. Schelter, Andrew Grimson, Christopher D. Armour and Eric E. Schadt. Their work appears in journals such as Journal of Geophysical Research Atmospheres, PLoS ONE, BMC Genomics, Proceedings of the National Academy of Sciences and Bioinformatics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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John C. Castle

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