James P. O’Connell

3.3k citations

36 papers · 2.6k · h-index 25

Impact in

Cancer Research top 2%
- Protease and Inhibitor Mechanisms
Hematology top 2%
- Blood Coagulation and Thrombosis Mechanisms

Papers in

Molecular Biology 15
Cancer Research 13
- Protease and Inhibitor Mechanisms 12

Co-authors: Andrew Docherty (9 shared papers)Gillian Murphy (4 shared papers)Frances Willenbrock (4 shared papers)Thomas Crabbe (6 shared papers)Eugene Tu (1 shared paper)William F. Butler (1 shared paper)Michael J. Heller (1 shared paper)Michael J. Heller (2 shared papers)
Journals: Nature Communications (3 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Biochemistry (3 papers)FEBS Letters (2 papers)Biochemical Journal (2 papers)
Partner nations: United Kingdom United States Canada

In The Last Decade

James P. O’Connell

35 papers receiving 2.5k citations

Peers

Countries citing papers authored by James P. O’Connell

Since Specialization

Citations

This map shows the geographic impact of James P. O’Connell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James P. O’Connell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James P. O’Connell more than expected).

Fields of papers citing papers by James P. O’Connell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James P. O’Connell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James P. O’Connell. The network helps show where James P. O’Connell may publish in the future.

Co-authors

The 25 scholars most cited alongside James P. O’Connell, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with James P. O’Connell Line = papers co-authored together James P. O’Connell links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 36 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Rapid determination of single base mismatch mutations in DNA hybrids by direct electric field control Proceedings of the National Academy of Sciences ·Ronald G. Sosnowski, Eugene Tu, William F. Butler, James P. O’Connell, Michael J. Heller	1997	362
2	The role of the C-terminal domain in collagenase and stromelysin specificity. Journal of Biological Chemistry ·Gillian Murphy, John Allan, Frances Willenbrock, Mark I. Cockett, James P. O’Connell, Andrew Docherty	1992	270
3	Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips Nature Biotechnology ·Jing Cheng, Edward L. Sheldon, Lei Wu, Adam Uribe, Louis O. Gerrue, John J. Carrino, Michael J. Heller, James P. O’Connell	1998	253
4	Regulation of Matrix Metalloproteinase Activity^a Annals of the New York Academy of Sciences ·Gillian Murphy, Frances Willenbrock, Thomas Crabbe, Mark O’Shea, Robyn L. Ward, Susan J. Atkinson, James P. O’Connell, Andrew Docherty	1994	183
5	The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases Trends in biotechnology ·Andrew Docherty, James P. O’Connell, Tom Crabbe, Sarojani Angal, Gillian Murphy	1992	168
6	Inactivation of tissue inhibitor of metalloproteinase‐1 by peroxynitrite FEBS Letters ·Emma R. Frears, Zhi Zhang, David R. Blake, James P. O’Connell, Paul G. Winyard	1996	141
7	Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B. Journal of Biological Chemistry ·James P. O’Connell, Frances Willenbrock, Andrew Docherty, D. Eaton, Gillian Murphy	1994	135
8	Isolation of Cultured Cervical Carcinoma Cells Mixed with Peripheral Blood Cells on a Bioelectronic Chip Analytical Chemistry ·Jing Cheng, Edward L. Sheldon, Lei Wu, Michael J. Heller, James P. O’Connell	1998	126
9	Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase Biochemical Journal ·P Hill, Andrew Docherty, K M K Bottomley, James P. O’Connell, J. Richard Morphy, John J. Reynolds, Murray C. Meikle	1995	83
10	Reciprocated matrix metalloproteinase activation: A process performed by interstitial collagenase and progelatinase A Biochemistry ·Thomas Crabbe, James P. O’Connell, Bryan John Smith, Andrew Docherty	1994	82
11	Human progelatinase A can be activated by matrilysin FEBS Letters ·Thomas Crabbe, Bryan Ronain Smith, James P. O’Connell, Andrew Docherty	1994	82
12	Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer Nature Communications ·James P. O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel E. Davis, David McMillan, T.L. Arakaki, Alex B. Burgin, David Fox, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P. Cossins, Tim Bourne, Alastair D. G. Lawson	2019	81
13	Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF Nature Communications ·David McMillan, C. Martinez-Fleites, John Porter, David Fox, Rachel E. Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair D. G. Lawson, Tim Bourne, James P. O’Connell	2021	63
14	Mutation of the Active Site Glutamic Acid of Human Gelatinase A: Effects on Latency, Catalysis, and the Binding of Tissue Inhibitor of Metalloproteinases-1 Biochemistry ·Thomas Crabbe, Stanley Zucker, Mark I. Cockett, Frances Willenbrock, Simon Tickle, James P. O’Connell, Janeen M. Scothern, Gillian Murphy, Andrew Docherty	1994	59
15	Antimicrobial Resistance and Bacterial Identification Utilizing a Microelectronic Chip Array Journal of Clinical Microbiology ·Lorelei Westin, Carolyn T. Miller, Dana Vollmer, David Canter, Ray Radtkey, Michael Nerenberg, James P. O’Connell	2001	58
16	mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging BMC Cell Biology ·Rahul Yadav, Pierre Burgos, Anthony W. Parker, Valentina Iadevaia, Christopher G. Proud, Rodger A. Allen, James P. O’Connell, Ananya Jeshtadi, Christopher D. Stubbs, Stanley W. Botchway	2013	55
17	Designing stapled peptides to inhibit protein‐protein interactions: An analysis of successes in a rapidly changing field Peptide Science ·Marie T. J. Bluntzer, James P. O’Connell, Terry Baker, Julien Michel, Alison N. Hulme	2020	41
18	A rapid, vital staining procedure for flow cytometric analysis of human reticulocytes Cytometry ·Burton H. Sage, James P. O’Connell, Thomas J. Mercolino	1983	40
19	A highly sensitive immunoassay system involving antibody-coated tubes and liposome-entrapped dye. Clinical Chemistry ·James P. O’Connell, Robert L. Campbell, Beverly Fleming, Thomas J. Mercolino, M D Johnson, D A McLaurin	1985	38
20	Potent and selective inhibitors of gelatinase-a 1. hydroxamic acid derivatives Bioorganic & Medicinal Chemistry Letters ·John Porter, Nigel R. A. Beeley, Byron A. Boyce, Barbara Mason, Andrew T. Millican, Kenneth Millar, J. C. Leonard, J. Richard Morphy, James P. O’Connell	1994	33

About James P. O’Connell

James P. O’Connell is a scholar working on Molecular Biology, Cancer Research, Oncology, Hematology and Radiology, Nuclear Medicine and Imaging, having authored 36 papers that have together received 2.6k indexed citations. Recurring topics across this work include Protease and Inhibitor Mechanisms (12 papers), Blood Coagulation and Thrombosis Mechanisms (8 papers), Peptidase Inhibition and Analysis (7 papers), Monoclonal and Polyclonal Antibodies Research (6 papers), Enzyme Production and Characterization (5 papers), Microfluidic and Capillary Electrophoresis Applications (3 papers), Quinazolinone synthesis and applications (2 papers) and Cell Adhesion Molecules Research (2 papers). The work is most often cited by research in Cancer Research (1.0k citations), Hematology (417 citations), Immunology and Allergy (188 citations), Oncology (652 citations) and Molecular Biology (1.1k citations). James P. O’Connell has collaborated with scholars based in United Kingdom, United States and Canada. Frequent co-authors include Andrew Docherty, Gillian Murphy, Frances Willenbrock, Thomas Crabbe, Eugene Tu, William F. Butler, Michael J. Heller, Michael J. Heller, Edward L. Sheldon and Lei Wu. Their work appears in journals such as Nature Communications, Bioorganic & Medicinal Chemistry Letters, Biochemistry, FEBS Letters and Biochemical Journal.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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James P. O’Connell

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