Hideyuki Oki

1.3k citations

30 papers · 1.0k · h-index 21

Impact in

Organic Chemistry top 10%
- Synthesis and biological activity
Cancer Research
- Protease and Inhibitor Mechanisms

Papers in

Molecular Biology 19
- Phosphodiesterase function and regulation 6
- Epigenetics and DNA Methylation 3
- Signaling Pathways in Disease 3
Oncology 12
- Peptidase Inhibition and Analysis 7

Co-authors: Masakuni Kori (5 shared papers)Kyoko Ogasahara (2 shared papers)T.H. Tahirov (2 shared papers)Susumu Tsunasawa (2 shared papers)Tomitake Tsukihara (2 shared papers)Katsuhide Yutani (2 shared papers)Kenjiro Sato (4 shared papers)Kazuhiro Ogata (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry (8 papers)Journal of Medicinal Chemistry (7 papers)Chemical and Pharmaceutical Bulletin (2 papers)ACS Chemical Biology (1 paper)European Journal of Medicinal Chemistry (1 paper)
Partner nations: Japan United States Russia

In The Last Decade

Hideyuki Oki

30 papers receiving 988 citations

Peers

Countries citing papers authored by Hideyuki Oki

Since Specialization

Citations

This map shows the geographic impact of Hideyuki Oki's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hideyuki Oki with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hideyuki Oki more than expected).

Fields of papers citing papers by Hideyuki Oki

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hideyuki Oki. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hideyuki Oki. The network helps show where Hideyuki Oki may publish in the future.

Co-authors

The 25 scholars most cited alongside Hideyuki Oki, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Hideyuki Oki Line = papers co-authored together Hideyuki Oki links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 30 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Crystal structure of methionine aminopeptidase from hyperthermophile, Pyrococcus furiosus Journal of Molecular Biology ·T.H. Tahirov, Hideyuki Oki, Tomitake Tsukihara, Kyoko Ogasahara, Katsuhide Yutani, Kazuhiro Ogata, Yukiko Izu, Susumu Tsunasawa, Ikunoshin Kato	1998	124
2	Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor Bioorganic & Medicinal Chemistry ·Naoki Miyamoto, Nozomu Sakai, Takaharu Hirayama, Kazuhiro Miwa, Yuya Oguro, Hideyuki Oki, Kengo Okada, Terufumi Takagi, Hidehisa Iwata, Yoshiko Awazu, Seiji Yamasaki, Toshiyuki Takeuchi, Hiroshi Miki, Akira Hori, Shinichi Imamura	2013	65
3	Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole Structure ·Tatsuki Asai, Naruhiko Adachi, Toshio Moriya, Hideyuki Oki, Takamitsu Maru, Masato Kawasaki, K. Suzuki, Si-Si Chen, Ryohei Ishii, Kazuko Yonemori, S. Igaki, Satoshi Yasuda, Satoshi Ogasawara, Toshiya Senda, Takeshi Murata	2021	62
4	Discovery of 1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor Journal of Medicinal Chemistry ·Jun Kunitomo, Masato Yoshikawa, Makoto Fushimi, Akira Kawada, John F. Quinn, Hideyuki Oki, Hironori Kokubo, Mitsuyo Kondo, Kosuke Nakashima, Naomi Kamiguchi, Kazunori Suzuki, Haruhide Kimura, Takahiko Taniguchi	2014	59
5	Discovery of Novel, Highly Potent, and Selective Quinazoline-2-carboxamide-Based Matrix Metalloproteinase (MMP)-13 Inhibitors without a Zinc Binding Group Using a Structure-Based Design Approach Journal of Medicinal Chemistry ·Hiroshi Nara, Kenjiro Sato, Takako Naito, Hideyuki Mototani, Hideyuki Oki, Yoshio Yamamoto, Haruhiko Kuno, Takashi Santou, Naoyuki Kanzaki, Jun Terauchi, Osamu Uchikawa, Masakuni Kori	2014	52
6	Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors Bioorganic & Medicinal Chemistry ·Shigemitsu Matsumoto, Naoki Miyamoto, Takaharu Hirayama, Hideyuki Oki, Kengo Okada, Michiko Tawada, Hidehisa Iwata, Kazuhide Nakamura, Seiji Yamasaki, Hiroshi Miki, Akira Hori, Shinichi Imamura	2013	50
7	Refined structure of orthorhombic lysozyme crystallized at high temperature: correlation between morphology and intermolecular contacts Acta Crystallographica Section D Biological Crystallography ·Hideyuki Oki, Y. Matsuura, Hiroshi Komatsu, A. A. Chernov	1999	50
8	Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach Journal of Medicinal Chemistry ·Hiroshi Nara, Akira Kaieda, Kenjiro Sato, Takako Naito, Hideyuki Mototani, Hideyuki Oki, Yoshio Yamamoto, Haruhiko Kuno, Takashi Santou, Naoyuki Kanzaki, Jun Terauchi, Osamu Uchikawa, Masakuni Kori	2016	46
9	Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2-b]furan Derivatives as a Novel Class of IKK.BETA. Inhibitors Chemical and Pharmaceutical Bulletin ·Hideyuki Sugiyama, Masato Yoshida, Kouji Mori, Tomohiro Kawamoto, Satoshi Sogabe, Terufumi Takagi, Hideyuki Oki, Toshimasa Tanaka, Hiroyuki Kimura, Yoshinori Ikeura	2007	41
10	T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice Neuropsychopharmacology ·Satoru Matsuda, Rina Baba, Hideyuki Oki, Shinji Morimoto, Masashi Toyofuku, S. Igaki, Yusuke Kamada, Shinji Iwasaki, Kota Matsumiya, Ryosuke Hibino, Hiroko Kamada, Takeshi Hirakawa, Misa Iwatani, Ken Tsuchida, Ryujiro Hara, Mitsuhiro Ito, Haruhide Kimura	2018	39
11	Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: Highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site Bioorganic & Medicinal Chemistry ·Hiroshi Nara, Kenjiro Sato, Takako Naito, Hideyuki Mototani, Hideyuki Oki, Yoshio Yamamoto, Haruhiko Kuno, Takashi Santou, Naoyuki Kanzaki, Jun Terauchi, Osamu Uchikawa, Masakuni Kori	2014	39
12	Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders Journal of Medicinal Chemistry ·Satoshi Mikami, Shigekazu Sasaki, Yasutomi Asano, Osamu Ujikawa, Shoji Fukumoto, Kosuke Nakashima, Hideyuki Oki, Naomi Kamiguchi, Haruka Imada, Hiroki Iwashita, Takahiko Taniguchi	2017	38
13	Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach Journal of Medicinal Chemistry ·Yusuke Kamada, Nozomu Sakai, Satoshi Sogabe, K. Ida, Hideyuki Oki, Kotaro Sakamoto, Weston Lane, G. Snell, Motoo Iida, Yasuhiro Imaeda, Junichi Sakamoto, Junji Matsui	2017	35
14	Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors Bioorganic & Medicinal Chemistry ·Mitsunori Kono, Takahiro Matsumoto, Tōru Kawamura, Atsushi Nishimura, Yoshihiro Kiyota, Hideyuki Oki, Junichi Miyazaki, S. Igaki, Craig A. Behnke, Masato Shimojo, Masakuni Kori	2012	32
15	Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay ACS Chemical Biology ·Misa Iwatani-Yoshihara, Masahiro Ito, Yoshihiro Ishibashi, Hideyuki Oki, Toshio Tanaka, Daisuke Morishita, Takashi Ito, Hiromichi Kimura, Yasuhiro Imaeda, Samuel Aparício, Atsushi Nakanishi, Tomohiro Kawamoto	2017	31
16	LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models Science Advances ·Rina Baba, Satoru Matsuda, Yuuichi Arakawa, Ryuji Yamada, Noriko Suzuki, Tatsuya Ando, Hideyuki Oki, S. Igaki, Masaki Daini, Yasushi Hattori, Shigemitsu Matsumoto, Mitsuhiro Ito, Atsushi Nakatani, Haruhide Kimura	2021	30
17	Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors Bioorganic & Medicinal Chemistry ·Hiroshi Nara, Kenjiro Sato, Akira Kaieda, Hideyuki Oki, Haruhiko Kuno, Takashi Santou, Naoyuki Kanzaki, Jun Terauchi, Osamu Uchikawa, Masakuni Kori	2016	29
18	Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders Journal of Medicinal Chemistry ·Satoshi Mikami, Shinji Nakamura, Tomoko Ashizawa, Izumi Nomura, Masanori Kawasaki, Shigekazu Sasaki, Hideyuki Oki, Hironori Kokubo, Isaac Hoffman, Hua Zou, Noriko Uchiyama, Kosuke Nakashima, Naomi Kamiguchi, Haruka Imada, Noriko Suzuki, Hiroki Iwashita, Takahiko Taniguchi	2017	29
19	A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases ACS Medicinal Chemistry Letters ·Hidehisa Iwata, Hideyuki Oki, Kengo Okada, Terufumi Takagi, Michiko Tawada, Yasushi Miyazaki, Shinichi Imamura, Akira Hori, J. David Lawson, Mark S. Hixon, Hiroyuki Kimura, Hiroshi Miki	2012	26
20	Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor Bioorganic & Medicinal Chemistry ·Masato Yoshikawa, Haruhi Kamisaki, Jun Kunitomo, Hideyuki Oki, Hironori Kokubo, Akihiro Suzuki, Tomomi Ikemoto, Kosuke Nakashima, Naomi Kamiguchi, Akina Harada, Haruhide Kimura, Takahiko Taniguchi	2015	25

About Hideyuki Oki

Hideyuki Oki is a scholar working on Molecular Biology, Oncology, Organic Chemistry, Pharmacology and Cancer Research, having authored 30 papers that have together received 1.0k indexed citations. Recurring topics across this work include Peptidase Inhibition and Analysis (7 papers), Phosphodiesterase function and regulation (6 papers), Cholinesterase and Neurodegenerative Diseases (5 papers), Protease and Inhibitor Mechanisms (4 papers), Carbohydrate Chemistry and Synthesis (3 papers), Epigenetics and DNA Methylation (3 papers), Enzyme Structure and Function (3 papers) and Signaling Pathways in Disease (3 papers). The work is most often cited by research in Organic Chemistry (297 citations), Cancer Research (137 citations), Oncology (233 citations), Molecular Biology (608 citations) and Toxicology (27 citations). Hideyuki Oki has collaborated with scholars based in Japan, United States and Russia. Frequent co-authors include Masakuni Kori, Kyoko Ogasahara, T.H. Tahirov, Susumu Tsunasawa, Tomitake Tsukihara, Katsuhide Yutani, Kenjiro Sato, Kazuhiro Ogata, Osamu Uchikawa and Ikunoshin Kato. Their work appears in journals such as Bioorganic & Medicinal Chemistry, Journal of Medicinal Chemistry, Chemical and Pharmaceutical Bulletin, ACS Chemical Biology and European Journal of Medicinal Chemistry.

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