Fred J. Fleitz

2.7k citations

19 papers · 2.2k · 1 hit paper · h-index 14

Impact in

Organic Chemistry top 2%
- Carbohydrate Chemistry and Synthesis
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
Biochemistry top 5%

Papers in

Molecular Biology 11
- Enzyme Catalysis and Immobilization 5
- Chemical Synthesis and Analysis 5
Organic Chemistry 8
- Catalytic C–H Functionalization Methods 2
- Synthesis and Catalytic Reactions 2

Co-authors: Paul N. Devine (4 shared papers)Emily C. Mundorff (2 shared papers)Jacob M. Janey (2 shared papers)Gjalt W. Huisman (2 shared papers)Anke Krebber (2 shared papers)William R. Jarvis (2 shared papers)Christopher K. Savile (2 shared papers)Jeffrey C. Moore (1 shared paper)
Journals: Organic Process Research & Development (4 papers)Tetrahedron Letters (3 papers)Tetrahedron Asymmetry (3 papers)The Journal of Organic Chemistry (2 papers)Organic Letters (2 papers)
Partner nations: United States United Kingdom

In The Last Decade

Fred J. Fleitz

19 papers receiving 2.1k citations

Fred J. Fleitz's Hit Papers

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Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture 2010 · 1.4k citations

Peers

Countries citing papers authored by Fred J. Fleitz

Since Specialization

Citations

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Fields of papers citing papers by Fred J. Fleitz

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Fred J. Fleitz. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Fred J. Fleitz. The network helps show where Fred J. Fleitz may publish in the future.

Co-authors

The 25 scholars most cited alongside Fred J. Fleitz, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Fred J. Fleitz Line = papers co-authored together Fred J. Fleitz links everyone, so they are left out of the graph.

All Works

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19 of 19 papers shown

#	Work
1	Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture Science ·Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff, Jeffrey C. Moore, Sarena Tam, William R. Jarvis, Jeffrey C. Colbeck, Anke Krebber, Fred J. Fleitz, Jos Brands, Paul N. Devine, Gjalt W. Huisman, Gregory Hughes Hit paper breakdown →	2010	1419
2	Palladium-Catalyzed Synthesis of Aryl Sulfides from Aryl Triflates The Journal of Organic Chemistry ·Nan Zheng, J. Christopher McWilliams, Fred J. Fleitz, Joseph D. Armstrong, R. P. Volante	1998	149
3	A highly catalytic robust palladium catalyzed cyanation of aryl bromides Tetrahedron Letters ·Peter E. Maligres, Marjorie S. Waters, Fred J. Fleitz, David Askin	1999	127
4	The formal oxidative addition of electron-rich transoid dienes to bromonaphthoquinones The Journal of Organic Chemistry ·John R. Grunwell, A. Karipides, Carl T. Wigal, Stephen W. Heinzman, John J. Parlow, Joan A. Surso, Laura Clayton, Fred J. Fleitz, Martin Daffner, Jonathan E. Stevens	1991	81
5	Enantioselective Synthesis of a Dual Orexin Receptor Antagonist Organic Letters ·Ian Mangion, Benjamin D. Sherry, Jingjun Yin, Fred J. Fleitz	2012	64
6	Asymmetric bioreduction of α,β-unsaturated nitriles and ketones Tetrahedron Asymmetry ·Birgit Kosjek, Fred J. Fleitz, Peter G. Dormer, Jeffrey T. Kuethe, Paul N. Devine	2008	63
7	On Pd-Catalyzed Cycloisomerization versus Cycloreduction. A General Strategy for Drimane Synthesis and a Short Total Synthesis of Siccanin Journal of the American Chemical Society ·Barry M. Trost, Fred J. Fleitz, William J. Watkins	1996	47
8	Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide–Ethylene Diamine Complex Organic Process Research & Development ·Ephraim M. Bassan, Carl A. Baxter, Gregory L. Beutner, Khateeta M. Emerson, Fred J. Fleitz, Simon R. Johnson, Stephen P. Keen, Mary M. Kim, Jeffrey T. Kuethe, William R. Leonard, Peter R. Mullens, Daniel J. Muzzio, Christopher Roberge, Nobuyoshi Yasuda	2011	38
9	Chromatography as an Enabling Technology in Pharmaceutical Process Development: Expedited Multikilogram Preparation of a Candidate HIV Protease Inhibitor Organic Process Research & Development ·Christopher J. Welch, Fred J. Fleitz, Firoz D. Antia, Pete Yehl, Robert B. Waters, Norihiro Ikemoto, Joseph D. Armstrong, David J. Mathre	2004	26
10	Kilogram Scale Synthesis of the Pyrazinone Acetic Acid Core of an Orally Efficacious Thrombin Inhibitor Synthetic Communications ·Fred J. Fleitz, Terry A. Lyle, Nan Zheng, Joseph D. Armstrong, R. P. Volante	2000	25
11	Ambient Pressure Desorption Ionization Mass Spectrometry in Support of Preclinical Pharmaceutical Development Organic Process Research & Development ·Roy Helmy, Wes Schafer, Leah Buhler, Stephen Marcinko, Brian Musselman, Erin N. Guidry, Herb Jenkins, Fred J. Fleitz, Christopher J. Welch	2010	21
12	Synthesis of optically active cyanohydrins from aromatic ketones: evidence of an increased substrate range and inverted stereoselectivity for the hydroxynitrile lyase from Linum usitatissimum Tetrahedron Asymmetry ·Christopher Roberge, Fred J. Fleitz, David Pollard, Paul N. Devine	2007	19
13	Asymmetric synthesis of cyanohydrin derived from pyridine aldehyde with cross-linked aggregates of hydroxynitrile lyases Tetrahedron Letters ·Christopher Roberge, Fred J. Fleitz, David Pollard, Paul N. Devine	2007	17
14	Approaches to installing a N-gem-dimethylmethylene-2-oxazolyl group and application to the synthesis of a second generation HIV protease inhibitor Tetrahedron Letters ·Norihiro Ikemoto, Ross A. Miller, Fred J. Fleitz, Li Li, Daniel E. Petrillo, Joseph F. Leone, JOSEPH LAQUIDARA JOSEPH LAQUIDARA, Benjamin Marcune, Sandor Karady, Joseph D. Armstrong, R. P. Volante	2005	14
15	A [2 + 2] Cycloaddition Route to Dimethylaminomethylene Vinamidinium Salts Organic Letters ·Ian W. Davies, David M. Tellers, C. Scott Shultz, Fred J. Fleitz, Dongwei Cai, Yongkui Sun	2002	13
16	Development of practical syntheses of potent non-nucleoside reverse transcriptase inhibitors Tetrahedron ·Jeffrey T. Kuethe, Yong‐Li Zhong, Mahbub Alam, Anthony Alorati, Gregory L. Beutner, Dongwei Cai, Fred J. Fleitz, Andrew Gibb, Amude M. Kassim, Kathleen Linn, Danny Mancheno, Benjamin Marcune, Philip J. Pye, Jeremy P. Scott, David M. Tellers, Bangping Xiang, Nobuyoshi Yasuda, Jingjun Yin, Ian W. Davies	2009	12
17	Total synthesis of a second generation HIV protease inhibitor Tetrahedron Asymmetry ·Donald R. Gauthier, Norihiro Ikemoto, Fred J. Fleitz, Ronald H. Szumigala, Dan Petrillo, Li Li, Robert A. Reamer, Joseph D. Armstrong, Peter Yehl, Naijun Wu, R. P. Volante	2003	11
18	Bio- and Chemocatalysis for the Synthesis of Late Stage SAR-Enabling Intermediates for ROMK Inhibitors and MK-7145 for the Treatment of Hypertension and Heart Failure Organic Process Research & Development ·Rebecca T. Ruck, Qinghao Chen, Nelo R. Rivera, Jongrock Kong, Ian Mangion, Lushi Tan, Fred J. Fleitz	2020	11
19	A Manufactured Enzyme for the Synthesis of Chiral Amines Synfacts ·Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff, Jeffery L. Moore, Sarena Tam, William R. Jarvis, Jill Colbeck, Anke Krebber, Fred J. Fleitz, Jos Brands, Paulette M. Devine, Gjalt W. Huisman, G. Hughes	2010	8

About Fred J. Fleitz

Fred J. Fleitz is a scholar working on Molecular Biology, Organic Chemistry, Inorganic Chemistry, Infectious Diseases and Spectroscopy, having authored 19 papers that have together received 2.2k indexed citations. Recurring topics across this work include Enzyme Catalysis and Immobilization (5 papers), Asymmetric Hydrogenation and Catalysis (5 papers), Chemical Synthesis and Analysis (5 papers), HIV/AIDS drug development and treatment (3 papers), Catalytic C–H Functionalization Methods (2 papers), Synthesis and Catalytic Reactions (2 papers), Bioactive Compounds and Antitumor Agents (2 papers) and Analytical Chemistry and Chromatography (2 papers). The work is most often cited by research in Organic Chemistry (1.0k citations), Biochemistry (172 citations), Molecular Biology (1.4k citations), Toxicology (57 citations) and Inorganic Chemistry (237 citations). Fred J. Fleitz has collaborated with scholars based in United States and United Kingdom. Frequent co-authors include Paul N. Devine, Emily C. Mundorff, Jacob M. Janey, Gjalt W. Huisman, Anke Krebber, William R. Jarvis, Christopher K. Savile, Jeffrey C. Moore, Gregory Hughes and Joseph D. Armstrong. Their work appears in journals such as Organic Process Research & Development, Tetrahedron Letters, Tetrahedron Asymmetry, The Journal of Organic Chemistry and Organic Letters.

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