Fred J. Fleitz

2.7k citations

19 papers · 2.3k · 1 hit paper · h-index 14

Impact in

Organic Chemistry top 2%
- Asymmetric Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Organic Chemistry Synthesis Methods
- Advanced Synthetic Organic Chemistry
Molecular Biology top 5%
- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction

Papers in

Organic Chemistry 12
- Asymmetric Synthesis and Catalysis 4
- Catalytic Cross-Coupling Reactions 3
- Organic Chemistry Synthesis Methods 2
- Synthesis and biological activity 2
- Advanced Synthetic Organic Chemistry 2
Spectroscopy 3

Co-authors: Paul N. Devine (4 shared papers)Emily C. Mundorff (1 shared paper)Jeffrey C. Moore (1 shared paper)Anke Krebber (1 shared paper)Christopher K. Savile (1 shared paper)William Robert Jarvis (1 shared paper)Gregory J Hughes (1 shared paper)Jacob M. Janey (1 shared paper)
Journals: Organic Process Research & Development (4 papers)Tetrahedron Letters (3 papers)Tetrahedron Asymmetry (3 papers)The Journal of Organic Chemistry (2 papers)Organic Letters (2 papers)
Partner nations: United States United Kingdom

In The Last Decade

Fred J. Fleitz

19 papers receiving 2.1k citations

Fred J. Fleitz's Hit Papers

align trajectories log scale

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture 2010 · 1.5k citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2010 Science

Peers

Countries citing papers authored by Fred J. Fleitz

Since Specialization

Citations

This map shows the geographic impact of Fred J. Fleitz's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Fred J. Fleitz with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Fred J. Fleitz more than expected).

Fields of papers citing papers by Fred J. Fleitz

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Fred J. Fleitz. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Fred J. Fleitz. The network helps show where Fred J. Fleitz may publish in the future.

Co-authors

The 25 scholars most cited alongside Fred J. Fleitz, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Fred J. Fleitz Line = papers co-authored together Fred J. Fleitz links everyone, so they are left out of the graph.

All Works

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19 of 19 papers shown

#	Work
1	Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture Science ·Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff, Jeffrey C. Moore, Sarena Tam, William Robert Jarvis, Jeffrey C. Colbeck, Anke Krebber Hit paper breakdown →	2010	1452
2	Palladium-Catalyzed Synthesis of Aryl Sulfides from Aryl Triflates The Journal of Organic Chemistry ·James Christopher McWilliams, Fred J. Fleitz, Joseph D. III Armstrong, Ralph P. Volante +1 other	1998	146
3	A highly catalytic robust palladium catalyzed cyanation of aryl bromides Tetrahedron Letters ·Peter E. Maligres, Marjorie See Waters, Fred J. Fleitz, David Askin	1999	130
4	The formal oxidative addition of electron-rich transoid dienes to bromonaphthoquinones The Journal of Organic Chemistry ·John R. Grunwell, ANASTAS KARIPIDES, Carl T. Wigal, Stephen W. Heinzman, John J. Parlow, Joan A. Surso, Laura Clayton, Fred J. Fleitz	1991	81
5	Enantioselective Synthesis of a Dual Orexin Receptor Antagonist Organic Letters ·Ian K. Mangion, Benjamin D. Sherry, Jingjun Yin, Fred J. Fleitz	2012	66
6	Asymmetric bioreduction of α,β-unsaturated nitriles and ketones Tetrahedron Asymmetry ·Birgit Kosjek, Fred J. Fleitz, Peter G. Dormer, Jeffrey T. Kuethe, Paul N. Devine	2008	64
7	1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia Journal of Medicinal Chemistry ·Petr Váchal, Shouwu Miao, Joan M. Pierce, Deodial Guiadeen, Vincent J. Colandrea, Matthew J. Wyvratt, Scott P. Salowe, Lisa M. Sonatore	2012	61
8	On Pd-Catalyzed Cycloisomerization versus Cycloreduction. A General Strategy for Drimane Synthesis and a Short Total Synthesis of Siccanin Journal of the American Chemical Society ·Barry M. Trost, Fred J. Fleitz +1 other	1996	45
9	Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide–Ethylene Diamine Complex Organic Process Research & Development ·Ephraim M. Bassan, Carl A. Baxter, Gregory L. Beutner, Khateeta M. Emerson, Fred J. Fleitz, Simon R. Johnson, Stephen P. Keen, Mary M. Kim	2011	39
10	Kilogram Scale Synthesis of the Pyrazinone Acetic Acid Core of an Orally Efficacious Thrombin Inhibitor Synthetic Communications ·Fred J. Fleitz, Terry A. Lyle, Joseph D. III Armstrong, Ralph P. Volante +1 other	2000	25
11	Chromatography as an Enabling Technology in Pharmaceutical Process Development: Expedited Multikilogram Preparation of a Candidate HIV Protease Inhibitor Organic Process Research & Development ·Christopher J. Welch, Fred J. Fleitz, Firoz D. Antia, Peter Yehl, Robert B. Waters, Norihiro Ikemoto, Joseph D. III Armstrong, David J. Mathre	2004	25
12	Ambient Pressure Desorption Ionization Mass Spectrometry in Support of Preclinical Pharmaceutical Development Organic Process Research & Development ·Roy Helmy, Wes A. Schafer, Leah Buhler, Stephen Marcinko, Brian D. Musselman, Erin N. Guidry, Herbert J. Jenkins, Fred J. Fleitz	2010	23
13	Synthesis of optically active cyanohydrins from aromatic ketones: evidence of an increased substrate range and inverted stereoselectivity for the hydroxynitrile lyase from Linum usitatissimum Tetrahedron Asymmetry ·Christopher Roberge, Fred J. Fleitz, David J. Pollard, Paul N. Devine	2007	19
14	Asymmetric synthesis of cyanohydrin derived from pyridine aldehyde with cross-linked aggregates of hydroxynitrile lyases Tetrahedron Letters ·Christopher Roberge, Fred J. Fleitz, David J. Pollard, Paul N. Devine	2007	17
15	Approaches to installing a N-gem-dimethylmethylene-2-oxazolyl group and application to the synthesis of a second generation HIV protease inhibitor Tetrahedron Letters ·Norihiro Ikemoto, Ross A. Miller, Fred J. Fleitz, Daniel E. Petrillo, Joseph F. Leone, Joseph M. Laquidara, Benjamin F. Marcune, Sandor Karady	2005	14
16	A [2 + 2] Cycloaddition Route to Dimethylaminomethylene Vinamidinium Salts Organic Letters ·Ian W. Davies, David M. Tellers, C. Scott Shultz, Fred J. Fleitz, Dongwei Cai, Yongkui Sun	2002	13
17	Development of practical syntheses of potent non-nucleoside reverse transcriptase inhibitors Tetrahedron ·Jeffrey T. Kuethe, Yong‐Li Zhong, Mahbub Alam, Anthony D. Alorati, Gregory L. Beutner, Dongwei Cai, Fred J. Fleitz, Andrew D. Gibb	2009	12
18	Total synthesis of a second generation HIV protease inhibitor Tetrahedron Asymmetry ·Donald R. Gauthier, Norihiro Ikemoto, Fred J. Fleitz, Ronald H. Jr. Szumigala, Daniel E. Petrillo, Robert A. Reamer, Joseph D. III Armstrong, Peter Yehl	2003	11
19	Bio- and Chemocatalysis for the Synthesis of Late Stage SAR-Enabling Intermediates for ROMK Inhibitors and MK-7145 for the Treatment of Hypertension and Heart Failure Organic Process Research & Development ·Rebecca T. Ruck, Qinghao Chen, Nelo R. Rivera, Jongrock Kong, Ian K. Mangion, Lushi Tan, Fred J. Fleitz	2020	11

About Fred J. Fleitz

Fred J. Fleitz is a scholar working on Organic Chemistry, Spectroscopy, Molecular Biology, Infectious Diseases and Pharmaceutical Science, having authored 19 papers that have together received 2.3k indexed citations. Recurring topics across this work include Enzyme Catalysis and Immobilization (5 papers), Asymmetric Synthesis and Catalysis (4 papers), HIV/AIDS drug development and treatment (3 papers), Catalytic Cross-Coupling Reactions (3 papers), Organic Chemistry Synthesis Methods (2 papers), Synthesis and biological activity (2 papers), Chemical Synthesis and Analysis (2 papers) and Advanced Synthetic Organic Chemistry (2 papers). The work is most often cited by research in Organic Chemistry (704 citations), Molecular Biology (1.4k citations), Biotechnology (54 citations), Environmental Chemistry (63 citations) and Inorganic Chemistry (91 citations). Fred J. Fleitz has collaborated with scholars based in United States and United Kingdom. Frequent co-authors include Paul N. Devine, Emily C. Mundorff, Jeffrey C. Moore, Anke Krebber, Christopher K. Savile, William Robert Jarvis, Gregory J Hughes, Jacob M. Janey, Gjalt W. Huisman and Joseph D. III Armstrong. Their work appears in journals such as Organic Process Research & Development, Tetrahedron Letters, Tetrahedron Asymmetry, The Journal of Organic Chemistry and Organic Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Fred J. Fleitz

Fred J. Fleitz's Hit Papers

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