Eric Legius

23.5k citations
298 papers · 12.2k · 2 hit papers · h-index 57

Impact in

  • Neurology top 0.1%
    • Neurofibromatosis and Schwannoma Cases
    • Neuroblastoma Research and Treatments
  • Genetics top 0.5%
    • Genetics and Neurodevelopmental Disorders
    • Genomic variations and chromosomal abnormalities

Papers in

  • Molecular Biology 100
    • Protein Tyrosine Phosphatases 22
    • RNA regulation and disease 13
  • Neurology 98
    • Neurofibromatosis and Schwannoma Cases 93
Co-authors
Hilde Brems (65 shared papers)Mie‐Jef Descheemaeker (15 shared papers)Douglas A. Marchuk (5 shared papers)Koenraad Devriendt (35 shared papers)Thomas W. Glover (9 shared papers)Gert Matthijs (26 shared papers)Thomy de Ravel (17 shared papers)J P Fryns (6 shared papers)
Journals
European Journal of Human Genetics (18 papers)Journal of Medical Genetics (16 papers)Clinical Genetics (16 papers)Genes Chromosomes and Cancer (13 papers)Human Mutation (13 papers)
Partner nations
BelgiumUnited StatesNetherlands

In The Last Decade

Eric Legius

291 papers receiving 11.9k citations

Eric Legius's Hit Papers

A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4) 2004 · 535 citations
5350+9+18Years since publication200400600
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

  • it has ≥500 total citations;
  • it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
  • it reaches the top citation threshold in at least one of its specific research topics.
  1. 2004 The Lancet
  2. 1998 Nature Genetics

Peers

Eric Legius
Comparison fields: 5 of 148
  • Neurology 4.0k
  • Genetics 2.7k
  • Genetics 747
  • Rheumatology 987
  • Pathology and Forensic Medicine 1.1k
Replace Bruce R. Korf with:
Bruce R. Korf United States
Vincent M. Riccardi United States
David Viskochil United States
Stanislas Lyonnet France
Jeanne Amiel France
Susan Huson United Kingdom
Kathryn N. North Australia
Meena Upadhyaya United Kingdom
Julie M. Gastier‐Foster United States
Douglas A. Marchuk United States
Eric Legius relative to Bruce R. Korf United States Bruce R. Korf's profile →
Citations per field
00.5×1.5×
Bruce R. Korf · 1×
Citations per year

Countries citing papers authored by Eric Legius

Since Specialization
Citations

This map shows the geographic impact of Eric Legius's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Eric Legius with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Eric Legius more than expected).

Fields of papers citing papers by Eric Legius

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Eric Legius. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Eric Legius. The network helps show where Eric Legius may publish in the future.

Co-authors

The 25 scholars most cited alongside Eric Legius, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Eric Legius Line = papers co-authored together Eric Legius links everyone, so they are left out of the graph.

All Works

20 of 20 papers shown

Showing the 20 most-cited of 298 papers — load more, or switch the sort, to bring in the rest.

#Work
1
SOX10 mutations in patients with Waardenburg-Hirschsprung disease
Nature Genetics ·Véronique Pingault, Nadège Bondurand, Kirsten Kuhlbrodt, Derk E. Goerich, Marie‐Odette Préhu, Aldamaria Puliti, Beate Herbarth, Irm Hermans‐Borgmeyer, Eric Legius, Gert Matthijs, Jeanne Amiel, Stanislas Lyonnet, Isabella Ceccherini, Giovanni Romeo, Jill Smith, Andrew Read, Michael Wegner, Michel Goossens
Hit paper breakdown →		1998619
2
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4)
The Lancet ·Carol J. Gallione, Gabriela M. Repetto, Eric Legius, Anil K. Rustgi, Susan Schelley, Sabine Tejpar, Grant A. Mitchell, Éric Drouin, Cornelius J.J. Westermann, Douglas A. Marchuk
Hit paper breakdown →		2004535
3
The NF1 tumor suppressor critically regulates TSC2 and mTOR
Proceedings of the National Academy of Sciences ·Cory M. Johannessen, Elizabeth E. Reczek, Marianne F. James, Hilde Brems, Eric Legius, Karen Cichowski
2005440
4
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies
Nature ·(unknown), Eline Beert, Éric Pasmant, Armelle Luscan, Hilde Brems, Nicolás Ortonne, Kristian Helin, Jason L. Hornick, Victor Mautner, Hildegard Kehrer‐Sawatzki, Wade Clapp, James E. Bradner, Michel Vidaud, Meena Upadhyaya, Eric Legius, Karen Cichowski
2014333
5
Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis
Nature Genetics ·Eric Legius, Douglas A. Marchuk, Francis S. Collins, Thomas W. Glover
1993321
6
Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotype
Nature Genetics ·Hilde Brems, Magdalena Chmara, Mourad Sahbatou, Ellen Denayer, Koji Taniguchi, Reiko Kato, Riet Somers, Ludwine Messiaen, Sofie De Schepper, Jean‐Pierre Fryns, Jan Cools, Peter Marynen, Gilles Thomas, Akihiko Yoshimura, Eric Legius
2007291
7
Intelligence and psychosocial adjustment in velocardiofacial syndrome: a study of 37 children and adolescents with VCFS.
Journal of Medical Genetics ·Ann Swillen, K Devriendt, Eric Legius, Bénédicte Eyskens, M Dumoulin, Marc Gewillig, J P Fryns
1997281
8
Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1
The Lancet Oncology ·Hilde Brems, Eline Beert, Thomy de Ravel, Eric Legius
2009240
9
Neurofibromatosis Type 2
SpringerReference ·Eric Legius, Mie‐Jef Descheemaeker, J P Fryns, Herman Van den Berghe
2012231
10
Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia
Nature Genetics ·Jennifer Hurvitz, Wafaa M. Suwairi, Wim Van Hul, Hatem El‐Shanti, Andrea Superti‐Furga, Jean Roudier, Daniel Ferreira Holderbaum, Richard M. Pauli, J. Kenneth Herd, Els Van Hul, Hossien Rezai-Delui, Eric Legius, Martine Le Merrer, Jamil Al-Alami, Sultan Bahabri, Matthew L. Warman
1999210
11
Elevated Risk for MPNST in NF1 Microdeletion Patients
The American Journal of Human Genetics ·(unknown), Hilde Brems, P. Wolkenstein, Dominique Vidaud, S. Pilotti, Federica Perrone, Victor‐Felix Mautner, Silke Frahm, Raf Sciot, Eric Legius
2003198
12
Communication with close and distant relatives in the context of genetic testing for hereditary breast and ovarian cancer in cancer patients
American Journal of Medical Genetics Part A ·Erna Claes, Gerry Evers‐Kiebooms, Andrea Boogaerts, Marleen Decruyenaere, Lieve Denayer, Eric Legius
2002193
13
Cognitive function and academic performance in neurofibrornatosis 1
Neurology ·Kathryn N. North, Vincent M. Riccardi, Carole Samango‐Sprouse, Rosalie E. Ferner, Bartlett D. Moore, Eric Legius, Nancy Ratner, Martha B. Denckla
1997184
14
PTPN11 mutations in LEOPARD syndrome
Journal of Medical Genetics ·Eric Legius, (unknown), (unknown), (unknown), (unknown), (unknown)
2002168
15
Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors
Genes Chromosomes and Cancer ·Eline Beert, Hilde Brems, Bruno Daniëls, Ivo De Wever, Frank Van Calenbergh, Joseph Schoenaers, Maria Dêbiec‐Rychter, Olivier Gevaert, Thomas De Raedt, Annick Van den Bruel, Thomy de Ravel, Karen Cichowski, Lan Kluwe, Victor Mautner, Raf Sciot, Eric Legius
2011162
16
Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients
Human Molecular Genetics ·Ophélia Maertens, Hans Prenen, Maria Dêbiec‐Rychter, Agnieszka Woźniak, Raf Sciot, Patrick Pauwels, Ivo De Wever, Joris Vermeesch, (unknown), Anne De Paepe, Frank Speleman, A. van Oosterom, Ludwine Messiaen, Eric Legius
2006156
17
TP53 mutations are frequent in malignant NFI tumors
Genes Chromosomes and Cancer ·Eric Legius, Herman A. Dierick, Rina Wu, Bryan K. Hall, Peter Marynen, Jean‐Jacques Cassiman, Thomas W. Glover
1994148
18
The behavioural phenotype in velo-cardio-facial syndrome (VCFS): from infancy to adolescence.
PubMed ·Ann Swillen, Koenraad Devriendt, Eric Legius, Peter Prinzie, Annick Vogels, Pol Ghesquière, Jean‐Pierre Fryns
1999143
19
Presymptomatic Identification of Cancers in Pregnant Women During Noninvasive Prenatal Testing
JAMA Oncology ·Frédéric Amant, Magali Verheecke, Iwona Włodarska, Luc Dehaspe, Paul Brady, Nathalie Brison, Kris Van Den Bogaert, Daan Dierickx, Vincent Vandecaveye, Thomas Tousseyn, Philippe Moerman, Adriaan Vanderstichele, Ignace Vergote, Patrick Neven, Patrick Berteloot, Katrien Putseys, Lode Danneels, Peter Vandenberghe, Eric Legius, Joris Vermeesch
2015138
20
Minimum prevalence, birth incidence and cause of death for Prader–Willi syndrome in Flanders
European Journal of Human Genetics ·Annick Vogels, Jenneke van den Ende, Kathelijn Keymolen, Geert Mortier, Koenraad Devriendt, Eric Legius, J P Fryns
2003137

About Eric Legius

Eric Legius is a scholar working on Molecular Biology, Neurology, Genetics, Pathology and Forensic Medicine and Pediatrics, Perinatology and Child Health, having authored 298 papers that have together received 12.2k indexed citations. Recurring topics across this work include Neurofibromatosis and Schwannoma Cases (93 papers), Prenatal Screening and Diagnostics (24 papers), Protein Tyrosine Phosphatases (22 papers), BRCA gene mutations in cancer (19 papers), Genomic variations and chromosomal abnormalities (17 papers), Sarcoma Diagnosis and Treatment (17 papers), Soft tissue tumor case studies (16 papers) and RNA regulation and disease (13 papers). The work is most often cited by research in Neurology (4.0k citations), Genetics (2.7k citations), Genetics (747 citations), Rheumatology (987 citations) and Pathology and Forensic Medicine (1.1k citations). Eric Legius has collaborated with scholars based in Belgium, United States and Netherlands. Frequent co-authors include Hilde Brems, Mie‐Jef Descheemaeker, Douglas A. Marchuk, Koenraad Devriendt, Thomas W. Glover, Gert Matthijs, Thomy de Ravel, J P Fryns, Eline Beert and Karen Cichowski. Their work appears in journals such as European Journal of Human Genetics, Journal of Medical Genetics, Clinical Genetics, Genes Chromosomes and Cancer and Human Mutation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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