David C. Rees

4.1k citations

17 papers · 3.3k · 2 hit papers · h-index 16

Impact in

Anesthesiology and Pain Medicine top 0.5%
- Anesthesia and Sedative Agents
Organic Chemistry top 1%
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Sulfur-Based Synthesis Techniques

Papers in

Organic Chemistry 9
- Click Chemistry and Applications 4
- Supramolecular Chemistry and Complexes 2
- Catalytic C–H Functionalization Methods 2
Molecular Biology 7
- Chemical Synthesis and Analysis 5

Co-authors: Christopher W. Murray (7 shared papers)David M. Wilson (1 shared paper)David C. Blakemore (1 shared paper)Andrew W. Thomas (1 shared paper)Ian Churcher (1 shared paper)Luis C. Misal Castro (1 shared paper)Anthony Wood (1 shared paper)Robin A. E. Carr (2 shared papers)
Journals: Journal of Medicinal Chemistry (3 papers)Angewandte Chemie International Edition (2 papers)Trends in Pharmacological Sciences (1 paper)Annual reports in medicinal chemistry (1 paper)Expert Opinion on Therapeutic Patents (1 paper)
Partner nations: United Kingdom Netherlands Switzerland

In The Last Decade

David C. Rees

16 papers receiving 3.1k citations

David C. Rees's Hit Papers

align trajectories log scale

Organic synthesis provides opportunities to transform drug discovery 2018 · 1.2k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2018 Nature Chemistry
2004 Nature Reviews Drug Discovery

Peers

Countries citing papers authored by David C. Rees

Since Specialization

Citations

This map shows the geographic impact of David C. Rees's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David C. Rees with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David C. Rees more than expected).

Fields of papers citing papers by David C. Rees

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David C. Rees. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David C. Rees. The network helps show where David C. Rees may publish in the future.

Co-authors

The 25 scholars most cited alongside David C. Rees, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David C. Rees Line = papers co-authored together David C. Rees links everyone, so they are left out of the graph.

All Works

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17 of 17 papers shown

#	Work
1	Organic synthesis provides opportunities to transform drug discovery Nature Chemistry ·David C. Blakemore, Luis C. Misal Castro, Ian Churcher, David C. Rees, Andrew W. Thomas, David M. Wilson, Anthony Wood Hit paper breakdown →	2018	1213
2	Fragment-based lead discovery Nature Reviews Drug Discovery ·David C. Rees, Miles Congreve, Christopher W. Murray, Robin A. E. Carr Hit paper breakdown →	2004	635
3	A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2). Angewandte Chemie International Edition ·A. Bom, Mark Philip Bradley, Ken Cameron, John K. Clark, J. van Egmond, Helen Feilden, E.J. MacLean, Alan W. Muir, Ronald Palin, David C. Rees, Ming‐Qiang Zhang	2002	388
4	Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide: Synthesis and Structure−Activity Relationships Journal of Medicinal Chemistry ·Julia M. Adam, David Jonathan Bennett, A. Bom, John K. Clark, Helen Feilden, Edward J. Hutchinson, Ronald Palin, Alan Prosser, David C. Rees, Georgina M. Rosair, Donald Stevenson, Gary J. Tarver, Ming‐Qiang Zhang	2002	198
5	Experiences in fragment-based drug discovery Trends in Pharmacological Sciences ·Christopher W. Murray, Marcel L. Verdonk, David C. Rees	2012	193
6	A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host Angewandte Chemie ·A. Bom, Mark Philip Bradley, Ken Cameron, John K. Clark, J. van Egmond, Helen Feilden, E.J. MacLean, Alan W. Muir, Ronald Palin, David C. Rees, Ming‐Qiang Zhang	2002	180
7	Opportunity Knocks: Organic Chemistry for Fragment‐Based Drug Discovery (FBDD) Angewandte Chemie International Edition ·Christopher W. Murray, David C. Rees	2015	157
8	Fragment-based drug discovery: opportunities for organic synthesis RSC Medicinal Chemistry ·Jeffrey D. St. Denis, Richard J. Hall, Christopher W. Murray, Tom D. Heightman, David C. Rees	2020	55
9	Fragment-to-Lead Medicinal Chemistry Publications in 2015 Journal of Medicinal Chemistry ·Christopher N. Johnson, Daniel A. Erlanson, Christopher W. Murray, David C. Rees	2016	55
10	Fragment-to-Lead Medicinal Chemistry Publications in 2016 Journal of Medicinal Chemistry ·Christopher N. Johnson, Daniel A. Erlanson, Wolfgang Jahnke, Paul N. Mortenson, David C. Rees	2017	43
11	A review of recent applications of cyclodextrins for drug discovery Expert Opinion on Therapeutic Patents ·Ming-Qiang Zhang, David C. Rees	1999	34
12	Organische Chemie für die fragmentbasierte Wirkstoffentwicklung (FBDD) Angewandte Chemie ·Christopher W. Murray, David C. Rees	2015	33
13	α-Chloronitroso compounds derived from carbohydrate ketones: cycloadditions with cyclic dienes, a synthesis of (−)-physoperuvine and a formal synthesis of (+)-epibatidine Journal of the Chemical Society Perkin Transactions 1 ·Adrian Hall, Patrick D. Bailey, David C. Rees, Georgina M. Rosair, R. H. WIGHTMAN	2000	29
14	C–H functionalisation tolerant to polar groups could transform fragment-based drug discovery (FBDD) Chemical Science ·Gianni Chessari, Rachel Grainger, Rhian S. Holvey, R. Frederick Ludlow, Paul N. Mortenson, David C. Rees	2021	25
15	Chapter 28 Fragment-Based Lead Discovery Annual reports in medicinal chemistry ·Miles Congreve, Christopher W. Murray, Robin A. E. Carr, David C. Rees	2007	18
16	Anionic Cyclophanes as Potential Reversal Agents of Muscle Relaxants by Chemical Chelation Bioorganic & Medicinal Chemistry Letters ·Kenneth S. Cameron, Lee A. Fielding, Rona Mason, Alan W. Muir, David C. Rees, Simon N. Thorn, Ming-Qiang Zhang	2002	17
17	Poorly performed lung function tests--the answer is not blowing in the wind. PubMed ·Elizabeth C. Behringer, David C. Rees, J. C. A. Davis	1991	0

About David C. Rees

David C. Rees is a scholar working on Organic Chemistry, Molecular Biology, Computational Theory and Mathematics, Pharmacology and Anesthesiology and Pain Medicine, having authored 17 papers that have together received 3.3k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (7 papers), Chemical Synthesis and Analysis (5 papers), Click Chemistry and Applications (4 papers), Microbial Natural Products and Biosynthesis (3 papers), Supramolecular Chemistry and Complexes (2 papers), Catalytic C–H Functionalization Methods (2 papers), Pharmaceutical Economics and Policy (2 papers) and Anesthesia and Sedative Agents (2 papers). The work is most often cited by research in Anesthesiology and Pain Medicine (362 citations), Organic Chemistry (1.6k citations), Pharmaceutical Science (214 citations), Developmental Neuroscience (132 citations) and Computational Theory and Mathematics (566 citations). David C. Rees has collaborated with scholars based in United Kingdom, Netherlands and Switzerland. Frequent co-authors include Christopher W. Murray, David M. Wilson, David C. Blakemore, Andrew W. Thomas, Ian Churcher, Luis C. Misal Castro, Anthony Wood, Robin A. E. Carr, Miles Congreve and Helen Feilden. Their work appears in journals such as Journal of Medicinal Chemistry, Angewandte Chemie International Edition, Trends in Pharmacological Sciences, Annual reports in medicinal chemistry and Expert Opinion on Therapeutic Patents.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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