David A. Egan

7.1k citations

48 papers · 5.9k · 2 hit papers · h-index 25

Impact in

Cancer Research top 1%
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
Oncology top 2%
- Cancer Cells and Metastasis

Papers in

Cancer Research 6
- MicroRNA in disease regulation 4
Oncology 8
- Drug Transport and Resistance Mechanisms 3
- Cancer Cells and Metastasis 2

Co-authors: Ronald Evans (4 shared papers)Carlos le Sage (3 shared papers)Remco Nagel (3 shared papers)Mariëtte Schrier (3 shared papers)Reuven Agami (3 shared papers)Giulio Maira (1 shared paper)Annunziato Mangiola (1 shared paper)Elly M. Mesman (1 shared paper)
Journals: Assay and Drug Development Technologies (3 papers)Proceedings of the National Academy of Sciences (3 papers)Nature (2 papers)The EMBO Journal (2 papers)Cell (2 papers)
Partner nations: Netherlands United States Italy

In The Last Decade

David A. Egan

46 papers receiving 5.8k citations

David A. Egan's Hit Papers

align trajectories log scale

Intra-tumour diversification in colorectal cancer at the single-cell level 2018 · 445 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2018 Nature
2017 Cell

Peers

Countries citing papers authored by David A. Egan

Since Specialization

Citations

This map shows the geographic impact of David A. Egan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David A. Egan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David A. Egan more than expected).

Fields of papers citing papers by David A. Egan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David A. Egan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David A. Egan. The network helps show where David A. Egan may publish in the future.

Co-authors

The 25 scholars most cited alongside David A. Egan, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David A. Egan Line = papers co-authored together David A. Egan links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 48 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity Cell ·Norman Sachs, Joep de Ligt, Oded Kopper, Ewa Gogola, Gergana Bounova, Fleur Weeber, Anjali Vanita Balgobind, Karin Wind-Mark Hit paper breakdown →	2017	1531
2	The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis Nature Cell Biology ·Qihong Huang, Kiranmai Gumireddy, Mariëtte Schrier, Carlos le Sage, Remco Nagel, Suresh Nair, David A. Egan, Guanghua Huang	2008	850
3	Regulation of the p27Kip1 tumor suppressor by miR‐221 and miR‐222 promotes cancer cell proliferation The EMBO Journal ·Carlos le Sage, Remco Nagel, David A. Egan, Mariëtte Schrier, Elly M. Mesman, Annunziato Mangiola, C. Anile, Giulio Maira	2007	706
4	Intra-tumour diversification in colorectal cancer at the single-cell level Nature ·Sophie F. Roerink, Nobuo Sasaki, Henry Lee-Six, Matthew D. Young, Ludmil B. Alexandrov, Sam Behjati, Thomas J. Mitchell, Sebastian Großmann Hit paper breakdown →	2018	445
5	Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1 Nature ·Coenraad P. Kuijl, Nigel D. L. Savage, Marije Marsman, Adriaan Willem Tuin, Lennert Janssen, David A. Egan, Mirjam Ketema, Rian van den Nieuwendijk	2007	267
6	Human Daxx regulates Fas‐induced apoptosis from nuclear PML oncogenic domains (PODs) The EMBO Journal ·Seiji Torii, David A. Egan, Ronald Evans +1 other	1999	237
7	Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening eLife ·Carla S. Veríssimo, René Overmeer, Bas Ponsioen, Jarno Drost, Sander Mertens, Ingrid Verlaan-Klink, Bastiaan van Gerwen, Marieke van de Ven	2016	218
8	Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy Acta Crystallographica Section D Biological Crystallography ·Janet M. Newman, David A. Egan, Thomas S. Walter, Ran Meged, Marouane Ben Jelloul, Joel L. Sussman, David Ian Stuart, Anastassis Perrakis A +1 other	2005	216
9	Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation Proceedings of the National Academy of Sciences ·Harald M. H. G. Albers, Anping Dong, Laurens A. van Meeteren, David A. Egan, Manjula Sunkara, Erica W. van Tilburg, Karianne G. Schuurman, Olaf van Tellingen	2010	176
10	Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling Proceedings of the National Academy of Sciences ·Vassilis Doucas, Marc Tini, David A. Egan, Ronald Evans	1999	151
11	In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells Stem Cell Research ·Henk‐Jan Prins, Arie Koen Braat, Debby Gawlitta, Wouter J.A. Dhert, David A. Egan, Estel Slump, Huipin Yuan, Paul James Coffer	2013	137
12	A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation Cell ·Petra Paul, Tineke van den Hoorn, Marlieke L.M. Jongsma, Mark J. Bakker, Rutger C.C. Hengeveld, Lennert Janssen, Peter Cresswell, David A. Egan	2011	120
13	Molecular genetics of acute promyelocytic leukemia Trends in Genetics ·Richard Jirui Lin, David A. Egan, Ronald Evans	1999	98
14	A High-Throughput Pharmaceutical Screen Identifies Compounds with Specific Toxicity against BRCA2-Deficient Tumors Clinical Cancer Research ·Bastiaan Evers, Eva Schut, Eline van der Burg, Tanya M. Braumuller, David A. Egan, Henne H. Holstege, Pauline A. H. Edser, David J. Adams	2009	69
15	Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin Journal of Medicinal Chemistry ·Harald M. H. G. Albers, Laurens A. van Meeteren, David A. Egan, Erica W. van Tilburg, Wouter H. Moolenaar, Huib Ovaa	2010	67
16	Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C Antimicrobial Agents and Chemotherapy ·Rachel Ulferts, Steffen Matthijn de Boer, Lonneke van der Linden, Lisa Bauer, Heyrhyoung Lyoo, María Jesus Maté, Julie Lichière, Bruno Canard	2016	65
17	Synthetic Lethal Screens Identify Gene Silencing Processes in Yeast and Implicate the Acetylated Amino Terminus of Sir3 in Recognition of the Nucleosome Core Molecular and Cellular Biology ·Tibor van Welsem, Floor Frederiks, Kitty F. Verzijlbergen, Alex W. Faber, Zara W. Nelson, David A. Egan, Daniel E. Gottschling, Fred van Leeuwen	2008	51
18	Signal Inhibitory Receptor on Leukocytes-1 Limits the Formation of Neutrophil Extracellular Traps, but Preserves Intracellular Bacterial Killing The Journal of Immunology ·Kristof Van Avondt, Maarten van der Linden, Paul H. Naccache, David A. Egan, Linde Meyaard	2016	50
19	An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4 Journal of Neuroscience ·Eljo Y. van Battum, Marieke G. Verhagen, Vamshidhar R. Vangoor, Yuki Fujita, Alwin A.H.A. Derijck, Eoghan O’Duibhir, Thijs de Gunst, Youri Adolfs	2017	49
20	High-Throughput T-Cell Epitope Discovery Through MHC Peptide Exchange Methods in molecular biology ·Sine Reker Hadrup, Mireille Toebes, Boris Rodenko, Arne Bakker, David A. Egan, Huib Ovaa, Ton N. Schumacher	2009	47

About David A. Egan

David A. Egan is a scholar working on Cancer Research, Oncology, Molecular Biology, Biophysics and Information Systems and Management, having authored 48 papers that have together received 5.9k indexed citations. Recurring topics across this work include MicroRNA in disease regulation (4 papers), Cell Image Analysis Techniques (4 papers), Scientific Computing and Data Management (3 papers), Drug Transport and Resistance Mechanisms (3 papers), Genomics and Chromatin Dynamics (3 papers), Retinoids in leukemia and cellular processes (3 papers), Cell death mechanisms and regulation (3 papers) and Cancer Cells and Metastasis (2 papers). The work is most often cited by research in Cancer Research (1.6k citations), Oncology (1.3k citations), Molecular Biology (1.5k citations), Biomedical Engineering (676 citations) and Cell Biology (199 citations). David A. Egan has collaborated with scholars based in Netherlands, United States and Italy. Frequent co-authors include Ronald Evans, Carlos le Sage, Remco Nagel, Mariëtte Schrier, Reuven Agami, Giulio Maira, Annunziato Mangiola, Elly M. Mesman, Maria Giulia Farace and Seiji Torii. Their work appears in journals such as Assay and Drug Development Technologies, Proceedings of the National Academy of Sciences, Nature, The EMBO Journal and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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David A. Egan

David A. Egan's Hit Papers

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All Works

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