Christine E. Brown

16.1k citations

178 papers · 9.7k · 2 hit papers · h-index 54

Impact in

Oncology top 0.2%
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
Immunology top 0.5%
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction

Papers in

Oncology 117
- CAR-T cell therapy research 106
- Cancer Immunotherapy and Biomarkers 9
Molecular Biology 47
- Viral Infectious Diseases and Gene Expression in Insects 18

Co-authors: Stephen J. Forman (76 shared papers)Michael C. Jensen (33 shared papers)Renate Starr (39 shared papers)Behnam Badie (33 shared papers)Brenda Aguilar (33 shared papers)Alan B. Sachs (3 shared papers)Jerry L. Workman (4 shared papers)Julie R. Ostberg (17 shared papers)
Journals: Blood (14 papers)Neuro-Oncology (9 papers)PLoS ONE (8 papers)Cancer Research (8 papers)Frontiers in Immunology (7 papers)
Partner nations: United States Canada China

In The Last Decade

Christine E. Brown

175 papers receiving 9.6k citations

Christine E. Brown's Hit Papers

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IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype 2019 · 345 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2019 Cancer Immunology Research
2015 Clinical Cancer Research

Peers

Countries citing papers authored by Christine E. Brown

Since Specialization

Citations

This map shows the geographic impact of Christine E. Brown's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christine E. Brown with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christine E. Brown more than expected).

Fields of papers citing papers by Christine E. Brown

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christine E. Brown. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christine E. Brown. The network helps show where Christine E. Brown may publish in the future.

Co-authors

The 25 scholars most cited alongside Christine E. Brown, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Christine E. Brown Line = papers co-authored together Christine E. Brown links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 178 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma Clinical Cancer Research ·Christine E. Brown, Behnam Badie, Michael E. Barish, Lihong Weng, Julie R. Ostberg, Wen-Chung Chang, Araceli Naranjo, Renate Starr, Jamie R. Wagner, Christine L. Wright, Yubo Zhai, James R. Bading, Julie A. Ressler, Jana Portnow, Massimo D’Apuzzo, Stephen J. Forman, Michael C. Jensen Hit paper breakdown →	2015	606
2	IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype Cancer Immunology Research ·Darya Alizadeh, Robyn A. Wong, Xin Yang, Dongrui Wang, Joseph R. Pecoraro, Cheng-Fu Kuo, Brenda Aguilar, Yue Qi, David K. Ann, Renate Starr, Ryan Urak, Xiuli Wang, Stephen J. Forman, Christine E. Brown Hit paper breakdown →	2019	345
3	T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia Blood ·Armen Mardiros, Cédric Dos Santos, Tinisha McDonald, Christine E. Brown, Xiuli Wang, Lihua E. Budde, Lauren Hoffman, Brenda Aguilar, Wen-Chung Chang, William Bretzlaff, Brenda Chang, Mahesh Jonnalagadda, Renate Starr, Julie R. Ostberg, Michael C. Jensen, Ravi Bhatia, Stephen J. Forman	2013	307
4	Recruitment of HAT Complexes by Direct Activator Interactions with the ATM-Related Tra1 Subunit Science ·Christine E. Brown, LeAnn J. Howe, Kyle M. Sousa, Stephen C. Alley, Michael J. Carrozza, Song Tan, Jerry L. Workman	2001	300
5	Specific Recognition and Killing of Glioblastoma Multiforme by Interleukin 13-Zetakine Redirected Cytolytic T Cells Cancer Research ·Kanwarpal Kahlon, Christine E. Brown, Laurence J.N. Cooper, Andrew Raubitschek, Stephen J. Forman, Michael C. Jensen	2004	291
6	The many HATs of transcription coactivators Trends in Biochemical Sciences ·Christine E. Brown, Theresa Lechner, Laura L. S. Howe, Jerry L. Workman	2000	284
7	Regional Delivery of Chimeric Antigen Receptor–Engineered T Cells Effectively Targets HER2+ Breast Cancer Metastasis to the Brain Clinical Cancer Research ·Saul J. Priceman, Dileshni Tilakawardane, Brook Jeang, Brenda Aguilar, John P. Murad, Anthony K. Park, Wen-Chung Chang, Julie R. Ostberg, Josh Neman, Rahul Jandial, Jana Portnow, Stephen J. Forman, Christine E. Brown	2017	255
8	Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma Science Translational Medicine ·Khun Visith Keu, Timothy H. Witney, Shahriar Yaghoubi, Jarrett Rosenberg, Anita Kurien, Rachel Magnusson, John Williams, Frezghi Habte, Jamie R. Wagner, Stephen J. Forman, Christine E. Brown, Martin Allen-Auerbach, Johannes Czernin, Winson W. Tang, Michael C. Jensen, Behnam Badie, Sanjiv S. Gambhir	2017	251
9	Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma Molecular Therapy ·Christine E. Brown, Brenda Aguilar, Renate Starr, Xin Yang, Wen-Chung Chang, Lihong Weng, Brenda Chang, Aniee Sarkissian, Alfonso Brito, James F. Sanchez, Julie R. Ostberg, Massimo D’Apuzzo, Behnam Badie, Michael E. Barish, Stephen J. Forman	2017	234
10	Poly(A) Tail Length Control in Saccharomyces cerevisiae Occurs by Message-Specific Deadenylation Molecular and Cellular Biology ·Christine E. Brown, Alan B. Sachs	1998	188
11	Neural Stem Cell–Mediated Enzyme/Prodrug Therapy for Glioma: Preclinical Studies Science Translational Medicine ·Karen S. Aboody, Joseph Najbauer, Marianne Z. Metz, Massimo D’Apuzzo, Margarita Gutova, Alexander J. Annala, Timothy W. Synold, Larry A. Couture, Suzette Blanchard, Rex Moats, Elizabeth Garcia, Soraya Aramburo, Valerie V. Valenzuela, R.T. Frank, Michael E. Barish, Christine E. Brown, Seung Up Kim, Behnam Badie, Jana Portnow	2013	184
12	Stem-like Tumor-Initiating Cells Isolated from IL13Rα2 Expressing Gliomas Are Targeted and Killed by IL13-Zetakine–Redirected T Cells Clinical Cancer Research ·Christine E. Brown, Renate Starr, Brenda Aguilar, Andrew F. Shami, Catalina Martínez, Massimo D’Apuzzo, Michael E. Barish, Stephen J. Forman, Michael C. Jensen	2012	184
13	Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications Frontiers in Immunology ·Hamid Reza Mirzaei, Analiz Rodriguez, Jennifer Kelly Shepphird, Christine E. Brown, Behnam Badie	2017	175
14	Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma Science Translational Medicine ·Dongrui Wang, Renate Starr, Wen-Chung Chang, Brenda Aguilar, Darya Alizadeh, Sarah Wright, Xin Yang, Alfonso Brito, Aniee Sarkissian, Julie R. Ostberg, Li Li, Yanhong Shi, Margarita Gutova, Karen S. Aboody, Behnam Badie, Stephen J. Forman, Michael E. Barish, Christine E. Brown	2020	170
15	CAR T cells for brain tumors: Lessons learned and road ahead Immunological Reviews ·David Akhavan, Darya Alizadeh, Dongrui Wang, Michael R. Weist, Jennifer Kelly Shepphird, Christine E. Brown	2019	170
16	Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity JCI Insight ·Dongrui Wang, Brenda Aguilar, Renate Starr, Darya Alizadeh, Alfonso Brito, Aniee Sarkissian, Julie R. Ostberg, Stephen J. Forman, Christine E. Brown	2018	168
17	Tumor PD-L1 co-stimulates primary human CD8+ cytotoxic T cells modified to express a PD1:CD28 chimeric receptor Molecular Immunology ·Megan E. Prosser, Christine E. Brown, Andrew F. Shami, Stephen J. Forman, Michael C. Jensen	2012	156
18	Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma Nature Communications ·Eugenia Zah, Eunwoo Nam, Vinya Bhuvan, Uyen Tran, Brenda Ji, Stanley B. Gosliner, Xiuli Wang, Christine E. Brown, Yvonne Y. Chen	2020	153
19	Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor–Redirected T Cells Against Multiple Myeloma Clinical Cancer Research ·Xiuli Wang, Miriam Walter, Ryan Urak, Lihong Weng, Christian Huynh, Laura Lim, ChingLam W. Wong, Wen-Chung Chang, Sandra H. Thomas, James F. Sanchez, Lu Yang, Christine E. Brown, Flavia Pichiorri, Myo Htut, Amrita Krishnan, Stephen J. Forman	2017	151
20	Chimeric Antigen Receptors With Mutated IgG4 Fc Spacer Avoid Fc Receptor Binding and Improve T Cell Persistence and Antitumor Efficacy Molecular Therapy ·Mahesh Jonnalagadda, Armen Mardiros, Ryan Urak, Xiuli Wang, Lauren Hoffman, Alyssa Bernanke, Wen-Chung Chang, William Bretzlaff, Renate Starr, Saul J. Priceman, Julie R. Ostberg, Stephen J. Forman, Christine E. Brown	2014	148

About Christine E. Brown

Christine E. Brown is a scholar working on Oncology, Molecular Biology, Immunology, Biomedical Engineering and Electrical and Electronic Engineering, having authored 178 papers that have together received 9.7k indexed citations. Recurring topics across this work include CAR-T cell therapy research (106 papers), Immunotherapy and Immune Responses (26 papers), Immune Cell Function and Interaction (22 papers), Nanowire Synthesis and Applications (21 papers), Viral Infectious Diseases and Gene Expression in Insects (18 papers), Glioma Diagnosis and Treatment (10 papers), Virus-based gene therapy research (9 papers) and Cancer Immunotherapy and Biomarkers (9 papers). The work is most often cited by research in Oncology (5.5k citations), Immunology (2.4k citations), Genetics (929 citations), Genetics (1.4k citations) and Molecular Biology (3.4k citations). Christine E. Brown has collaborated with scholars based in United States, Canada and China. Frequent co-authors include Stephen J. Forman, Michael C. Jensen, Renate Starr, Behnam Badie, Brenda Aguilar, Alan B. Sachs, Jerry L. Workman, Julie R. Ostberg, Michael E. Barish and Dongrui Wang. Their work appears in journals such as Blood, Neuro-Oncology, PLoS ONE, Cancer Research and Frontiers in Immunology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Christine E. Brown

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Christine E. Brown

Christine E. Brown's Hit Papers

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Fields of papers citing papers by Christine E. Brown

All Works

About Christine E. Brown

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