Bruce D. Roth

3.3k citations

61 papers · 2.6k · h-index 30

Impact in

Organic Chemistry top 1%
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Synthesis and biological activity
Biotechnology top 2%

Papers in

Molecular Biology 35
- Plant biochemistry and biosynthesis 8
- Steroid Chemistry and Biochemistry 7
Surgery 26
- Lipoproteins and Cardiovascular Health 19
- Cholesterol and Lipid Metabolism 16

Co-authors: George A. Kraus (5 shared papers)Drago R. Sliskovic (18 shared papers)Roger S. Newton (10 shared papers)Brian R. Krause (16 shared papers)W. Howard Roark (9 shared papers)Pauline J. Sanfilippo (2 shared papers)Andrew S. Kende (2 shared papers)Erika Ferguson (6 shared papers)
Journals: Journal of Medicinal Chemistry (18 papers)Bioorganic & Medicinal Chemistry Letters (7 papers)Tetrahedron Letters (6 papers)The Journal of Organic Chemistry (4 papers)Bioorganic & Medicinal Chemistry (4 papers)
Partner nations: United States United Kingdom Russia

In The Last Decade

Bruce D. Roth

61 papers receiving 2.4k citations

Peers

Countries citing papers authored by Bruce D. Roth

Since Specialization

Citations

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Fields of papers citing papers by Bruce D. Roth

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bruce D. Roth. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bruce D. Roth. The network helps show where Bruce D. Roth may publish in the future.

Co-authors

The 25 scholars most cited alongside Bruce D. Roth, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Bruce D. Roth Line = papers co-authored together Bruce D. Roth links everyone, so they are left out of the graph.

All Works

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#	Work
1	Synthetic studies toward verrucarol. 2. Synthesis of the AB ring system The Journal of Organic Chemistry ·George A. Kraus, Bruce D. Roth	1980	215
2	1 The Discovery and Development of Atorvastatin, A Potent Novel Hypolipidemic Agent Progress in medicinal chemistry ·Bruce D. Roth	2002	170
3	Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus Journal of Medicinal Chemistry ·Bruce D. Roth, C. John Blankley, Alexander Chucholowski, Erika Ferguson, M. L. HOEFLE, Daniel F. Ortwine, Roger S. Newton, Catherine Sekerke, Drago R. Sliskovic, Michael Wilson	1991	151
4	Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 1. Thiazolone and Oxazolone Series Journal of Medicinal Chemistry ·Yuntao Song, David T. Connor, Robert Doubleday, Roderick J. Sorenson, Anthony D. Sercel, Paul C. Unangst, Bruce D. Roth, Richard B. Gilbertsen, K Chan, Denis J. Schrier, Antonio Guglietta, Dirk A. Bornemeier, Richard D. Dyer	1999	117
5	Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series Journal of Medicinal Chemistry ·Yuntao Song, David T. Connor, Anthony D. Sercel, Roderick J. Sorenson, Robert Doubleday, Paul C. Unangst, Bruce D. Roth, Vlad G. Beylin, Richard B. Gilbertsen, K Chan, Denis J. Schrier, Antonio Guglietta, Dirk A. Bornemeier, Richard D. Dyer	1999	105
6	Conversion of lactones into ethers The Journal of Organic Chemistry ·George A. Kraus, Kevin Frazier, Bruce D. Roth, Michael Täschner, Kent Neuenschwander	1981	90
7	Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors Journal of Medicinal Chemistry ·Patrick O’Brien, Daniel F. Ortwine, A.G. Pavlovsky, Joseph A. Picard, Drago R. Sliskovic, Bruce D. Roth, Richard D. Dyer, Linda L. Johnson, Chiu Fai Man, Hussein Hallak	2000	88
8	The convergent synthesis of CI-981, an optically active, highly potent, tissue selective inhibitor of HMG-CoA reductase Tetrahedron Letters ·Kelvin L. Baumann, Donald E. Butler, Carl F. Deering, Kenneth E. Mennen, Alan Millar, Thomas N. Nanninga, Charles W. Palmer, Bruce D. Roth	1992	87
9	Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. CI-1011: An Acyl Sulfamate with Unique Cholesterol-Lowering Activity in Animals Fed Noncholesterol-Supplemented Diets Journal of Medicinal Chemistry ·Helen T. Lee, Drago R. Sliskovic, Joseph A. Picard, Bruce D. Roth, Wendell Wierenga, James L. Hicks, Richard F. Bousley, Katherine L. Hamelehle, Reynold Homan, Cecilia L. Speyer, Richard L. Stanfield, Brian R. Krause	1996	81
10	Novel Nonpeptide CCK-B Antagonists: Design and Development of Quinazolinone Derivatives as Potent, Selective, and Orally Active CCK-B Antagonists Journal of Medicinal Chemistry ·Janak Padia, Mark J. Field, Joanna P. Hinton, Ken Meecham, Julius C. Pablo, R.D. Pinnock, Bruce D. Roth, Lakhbir Singh, Nirmala Suman‐Chauhan, Bharat K. Trivedi, Louise Webdale	1998	77
11	Mechanism and regioisomeric control in palladium(II)-mediated cycloalkenylations. A novel total synthesis of (.+-.)-quadrone Journal of the American Chemical Society ·Andrew S. Kende, Bruce D. Roth, Pauline J. Sanfilippo, Thomas J. Blacklock	1982	77
12	Facile, palladium(II)-mediated synthesis of bridged and spirocyclic bicycloalkenones Journal of the American Chemical Society ·Andrew S. Kende, Bruce D. Roth, Pauline J. Sanfilippo	1982	76
13	Contemporary Drug Synthesis Jie Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth	2004	75
14	Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: Comparison with selected HMG-CoA reductase inhibitors Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ·Thomas Bocan, Erika Ferguson, W. McNally, Paul D. Uhlendorf, Sandra Bak Mueller, Peter D. DeHart, Drago R. Sliskovic, Bruce D. Roth, Brian R. Krause, Roger S. Newton	1992	73
15	Metabolism and Excretion of Atorvastatin in Rats And Dogs Drug Metabolism and Disposition ·Ann E. Black, Roger N. Hayes, Bruce D. Roth, Peter W. K. Woo, Thomas F. Woolf	1999	71
16	The synthesis of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a highly potent, tissue selective inhibitor of HMG-CoA reductase Tetrahedron Letters ·Philip L. Brower, Donald E. Butler, Carl F. Deering, Tung Le, Alan Millar, Thomas N. Nanninga, Bruce D. Roth	1992	70
17	Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation Atherosclerosis ·Thomas Bocan, Michał Mazur, Sandra Bak Mueller, Edie Quenby Brown, Drago R. Sliskovic, Patrick O’Brien, Mark W. Creswell, Helen Lee, Paul D. Uhlendorf, Bruce D. Roth, Roger S. Newton	1994	70
18	X‐ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: Implications for inhibitor selectivity Protein Science ·A.G. Pavlovsky, Mark Williams, Qi‐Zhuang Ye, Daniel F. Ortwine, Claude F. Purchase, Andrew D. White, V. Dhanaraj, Bruce D. Roth, Linda L. Johnson, Donald Hupe, Christine Humblet, Tom L. Blundell	1999	65
19	Synthesis of a chiral synthon for the lactone portion of compactin and mevinolin Tetrahedron Letters ·Bruce D. Roth, W. Howard Roark	1988	61
20	Phthalide annulation: the synthesis of kalafungin, pachybasin and chrysophanol The Journal of Organic Chemistry ·George A. Kraus, Hidetsura Cho, Steven R. Crowley, Bruce D. Roth, Hirohiko Sugimoto, Susan Prugh	1983	60

About Bruce D. Roth

Bruce D. Roth is a scholar working on Molecular Biology, Surgery, Organic Chemistry, Pharmacology and Cancer Research, having authored 61 papers that have together received 2.6k indexed citations. Recurring topics across this work include Lipoproteins and Cardiovascular Health (19 papers), Cholesterol and Lipid Metabolism (16 papers), Plant biochemistry and biosynthesis (8 papers), Steroid Chemistry and Biochemistry (7 papers), Pharmacogenetics and Drug Metabolism (6 papers), Computational Drug Discovery Methods (6 papers), Microbial Metabolism and Applications (5 papers) and Cancer, Lipids, and Metabolism (5 papers). The work is most often cited by research in Organic Chemistry (1.4k citations), Biotechnology (230 citations), Pharmacology (317 citations), Cancer Research (228 citations) and Computational Theory and Mathematics (253 citations). Bruce D. Roth has collaborated with scholars based in United States, United Kingdom and Russia. Frequent co-authors include George A. Kraus, Drago R. Sliskovic, Roger S. Newton, Brian R. Krause, W. Howard Roark, Pauline J. Sanfilippo, Andrew S. Kende, Erika Ferguson, M. L. HOEFLE and Daniel F. Ortwine. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, The Journal of Organic Chemistry and Bioorganic & Medicinal Chemistry.

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