Bill J. Smith

2.6k citations

29 papers · 1.6k · h-index 20

Impact in

Pharmacology top 1%
- Pharmacogenetics and Drug Metabolism
Oncology top 5%
- Drug Transport and Resistance Mechanisms

Papers in

Oncology 17
- Drug Transport and Resistance Mechanisms 14
Molecular Biology 10
- Protein Interaction Studies and Fluorescence Analysis 2

Co-authors: Cuiping Chen (5 shared papers)Xingrong Liu (3 shared papers)Xingrong Liu (2 shared papers)I.G. Sipes (3 shared papers)Donald R. Mattison (3 shared papers)John P. Gibbs (3 shared papers)Meihua Tu (1 shared paper)Natilie Hosea (3 shared papers)
Journals: Drug Metabolism and Disposition (10 papers)Journal of Pharmacology and Experimental Therapeutics (3 papers)Journal of Proteome Research (1 paper)Pharmacological Research (1 paper)Biopharmaceutics & Drug Disposition (1 paper)
Partner nations: United States United Kingdom Germany

In The Last Decade

Bill J. Smith

28 papers receiving 1.6k citations

Peers

Countries citing papers authored by Bill J. Smith

Since Specialization

Citations

This map shows the geographic impact of Bill J. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bill J. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bill J. Smith more than expected).

Fields of papers citing papers by Bill J. Smith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bill J. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bill J. Smith. The network helps show where Bill J. Smith may publish in the future.

Co-authors

The 25 scholars most cited alongside Bill J. Smith, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Bill J. Smith Line = papers co-authored together Bill J. Smith links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 29 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches The Journal of Clinical Pharmacology ·Natilie Hosea, Wendy T. Collard, Susan Cole, Tristan S. Maurer, Rick X. Fang, Hannah M. Jones, Shefali Kakar, Yasuhiro Nakai, Bill J. Smith, Rob Webster, Kevin Beaumont	2009	206
2	Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human Pharmacological Research ·Mark S. Warren, Noa Zerangue, Katie Woodford, Lori M. Roberts, Emily Tate, Bo Feng, Cheryl Li, Thomas J. Feuerstein, John P. Gibbs, Bill J. Smith	2009	192
3	DEVELOPMENT OF A COMPUTATIONAL APPROACH TO PREDICT BLOOD-BRAIN BARRIER PERMEABILITY Drug Metabolism and Disposition ·Xingrong Liu, Meihua Tu, Rebecca S. Kelly, Cuiping Chen, Bill J. Smith	2004	182
4	Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding Journal of Pharmacology and Experimental Therapeutics ·Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick Nelson, Mark A. Szewc, Jeffery Van Deusen	2005	136
5	Progress in Brain Penetration Evaluation in Drug Discovery and Development Journal of Pharmacology and Experimental Therapeutics ·Xingrong Liu, Cuiping Chen, Bill J. Smith	2008	130
6	Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration Drug Metabolism and Disposition ·Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick Nelson, Mark A. Szewc, Jeffrey Van Deusen	2006	129
7	The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity Toxicology and Applied Pharmacology ·Bill J. Smith, Donald R. Mattison, I.G. Sipes	1990	91
8	Utility of Mdr1-Gene Deficient Mice in Assessing the Impact of P-glycoprotein on Pharmacokinetics and Pharmacodynamics in Drug Discovery and Development Current Drug Metabolism ·Cuiping Chen, Xingrong Liu, Bill J. Smith	2003	67
9	Bioactivation of xenobiotics by prostaglandin H synthase Chemico-Biological Interactions ·Bill J. Smith, John F. Curtis, Thomas E. Eling	1991	61
10	Comparison of random and serial sections in assessment of ovarian toxicity Reproductive Toxicology ·Bill J. Smith, David R. Plowchalk, I.G. Sipes, Donald R. Mattison	1991	49
11	Metabolism, excretion and pharmacokinetics of [¹⁴C]crizotinib following oral administration to healthy subjects Xenobiotica ·Theodore R. Johnson, Weiwei Tan, Lance Goulet, Evan B. Smith, Shinji Yamazaki, Gregory S. Walker, Melissa O’Gorman, Gabriella Bedarida, Helen Y. Zou, James G. Christensen, Leslie Nguyen, Zhongzhou Shen, Deepak Dalvie, Akintunde Bello, Bill J. Smith	2014	46
12	Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model Drug Metabolism and Disposition ·Shinji Yamazaki, Theodore R. Johnson, Bill J. Smith	2015	41
13	Expression and Functional Analysis of Hepatic Cytochromes P450, Nuclear Receptors, and Membrane Transporters in 10- and 25-Week-Old db/db Mice Drug Metabolism and Disposition ·Justine L. Lam, Ying Jiang, Tao Zhang, Eric Y. Zhang, Bill J. Smith	2010	36
14	Mutagenic activation of benzidine requires prior bacterial acetylation and subsequent conversion by prostaglandin H synthase to 4-nitro-4'-(acetylamino)biphenyl Chemical Research in Toxicology ·Bill J. Smith, Lillian S. DeBruin, P. David Josephy, Thomas E. Eling	1992	35
15	In Vitro Characterization of Axitinib Interactions with Human Efflux and Hepatic Uptake Transporters: Implications for Disposition and Drug Interactions Drug Metabolism and Disposition ·Eric L. Reyner, Samantha Sevidal, Mark A. West, Andrea Clouser-Roche, Sascha Freiwald, Katherine S. Fenner, Mohammed Ullah, Caroline A. Lee, Bill J. Smith	2013	32
16	Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans Drug Metabolism and Disposition ·Bill J. Smith, Yazdi K. Pithavala, Hai‐Zhi Bu, Ping Kang, Brian Hee, Alan Deese, William F. Pool, Karen J. Klamerus, Xinglin Wu, Deepak Dalvie	2014	31
17	P-Glycoprotein Efflux at the Blood-Brain Barrier Mediates Differences in Brain Disposition and Pharmacodynamics between Two Structurally Related Neurokinin-1 Receptor Antagonists Journal of Pharmacology and Experimental Therapeutics ·Bill J. Smith, Angela C. Doran, Stafford McLean, F. David Tingley, Brian T. O’Neill, Shama Kajiji	2001	27
18	Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo Drug Metabolism and Disposition ·Congrong Niu, Yujin Wang, Xiaofeng Zhao, Sam Tep, Eisuke Murakami, Raju Subramanian, Bill J. Smith, Yurong Lai	2019	22
19	Prostaglandins and cancer Prostaglandins ·Bill J. Smith, M. R. Wills, J. G. Savory	1982	21
20	Application of Target-Mediated Drug Disposition Model to Small Molecule Heat Shock Protein 90 Inhibitors Drug Metabolism and Disposition ·Shinji Yamazaki, Zhongzhou Shen, Ying Jiang, Bill J. Smith, Paolo Vicini	2013	20

About Bill J. Smith

Bill J. Smith is a scholar working on Oncology, Molecular Biology, Pharmacology, Pediatrics, Perinatology and Child Health and Computational Theory and Mathematics, having authored 29 papers that have together received 1.6k indexed citations. Recurring topics across this work include Drug Transport and Resistance Mechanisms (14 papers), Pharmacogenetics and Drug Metabolism (9 papers), Pharmacological Effects and Toxicity Studies (6 papers), Computational Drug Discovery Methods (5 papers), Inflammatory mediators and NSAID effects (3 papers), Carcinogens and Genotoxicity Assessment (2 papers), Chronic Myeloid Leukemia Treatments (2 papers) and Protein Interaction Studies and Fluorescence Analysis (2 papers). The work is most often cited by research in Pharmacology (324 citations), Oncology (651 citations), Neurology (153 citations), Pediatrics, Perinatology and Child Health (296 citations) and Biochemistry (69 citations). Bill J. Smith has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Cuiping Chen, Xingrong Liu, Xingrong Liu, I.G. Sipes, Donald R. Mattison, John P. Gibbs, Meihua Tu, Natilie Hosea, Thomas E. Eling and Angela C. Doran. Their work appears in journals such as Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, Journal of Proteome Research, Pharmacological Research and Biopharmaceutics & Drug Disposition.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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