Anja Sieber

2.6k citations

21 papers · 1.5k · 1 hit paper · h-index 13

Impact in

Cancer Research top 10%
- Cancer Genomics and Diagnostics
Molecular Biology top 10%
- Gene Regulatory Network Analysis
- Single-cell and spatial transcriptomics
- Bioinformatics and Genomic Networks
- CRISPR and Genetic Engineering
- Melanoma and MAPK Pathways

Papers in

Cancer Research 4
- Cancer Genomics and Diagnostics 2
Molecular Biology 13
- Melanoma and MAPK Pathways 5
- Gene Regulatory Network Analysis 3
- CRISPR and Genetic Engineering 2
- Pluripotent Stem Cells Research 2

Co-authors: Nils Blüthgen (17 shared papers)Bertram Klinger (12 shared papers)Mathew J. Garnett (2 shared papers)Julio Sáez-Rodríguez (2 shared papers)Florian Uhlitz (3 shared papers)Martina Klünemann (1 shared paper)Michaël Schubert (1 shared paper)Sascha Sauer (1 shared paper)
Journals: Molecular Systems Biology (4 papers)Bioinformatics (4 papers)Nature Communications (2 papers)Advances in Biological Regulation (1 paper)European Journal of Immunology (1 paper)
Partner nations: Germany Netherlands United Kingdom

In The Last Decade

Anja Sieber

21 papers receiving 1.5k citations

Anja Sieber's Hit Papers

align trajectories log scale

Perturbation-response genes reveal signaling footprints in cancer gene expression 2017 · 649 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2017 Nature Communications

Peers

Countries citing papers authored by Anja Sieber

Since Specialization

Citations

This map shows the geographic impact of Anja Sieber's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Anja Sieber with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Anja Sieber more than expected).

Fields of papers citing papers by Anja Sieber

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Anja Sieber. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Anja Sieber. The network helps show where Anja Sieber may publish in the future.

Co-authors

The 25 scholars most cited alongside Anja Sieber, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Anja Sieber Line = papers co-authored together Anja Sieber links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 21 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Perturbation-response genes reveal signaling footprints in cancer gene expression Nature Communications ·Michaël Schubert, Bertram Klinger, Martina Klünemann, Anja Sieber, Florian Uhlitz, Sascha Sauer, Mathew J. Garnett, Nils Blüthgen Hit paper breakdown →	2017	649
2	Strong negative feedback from Erk to Raf confers robustness to MAPK signalling Molecular Systems Biology ·Raphaela Fritsche‐Guenther, Franziska Witzel, Anja Sieber, Ricarda Herr, Nadine Schmidt, Sandra L. Braun, Tilman Brummer, Christine Sers	2011	161
3	The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network Cell stem cell ·Edda G. Schulz, Johannes Meisig, Tomonori Nakamura, Ikuhiro Okamoto, Anja Sieber, Christel Picard, Maud Borensztein, Mitinori Saitou	2014	132
4	Network quantification of EGFR signaling unveils potential for targeted combination therapy Molecular Systems Biology ·Bertram Klinger, Anja Sieber, Raphaela Fritsche‐Guenther, Franziska Witzel, Leanne Berry, Dirk Schumacher, Yibing Yan, Pawel Durek	2013	127
5	Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer EMBO Molecular Medicine ·Florian Uhlitz, Philip Bischoff, Stefan Peidli, Anja Sieber, Alexandra Trinks, Mareen Lüthen, Benedikt Obermayer, Eric Blanc	2021	103
6	Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type–Specific Dynamic Logic Models Cancer Research ·Federica Eduati, Victoria Doldàn-Martelli, Bertram Klinger, Thomas Cokelaer, Anja Sieber, Fiona Kogera, Mathurin Dorel, Mathew J. Garnett	2017	81
7	Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma Cell Death and Disease ·Ulrike Schoetz, Diana Klein, Julia Heß, Seyd Shnayien, Steffen Spoerl, Michael Orth, Samet Mutlu, Roman Hennel	2021	55
8	An immediate–late gene expression module decodes ERK signal duration Molecular Systems Biology ·Florian Uhlitz, Anja Sieber, Emanuel Wyler, Raphaela Fritsche‐Guenther, Johannes Meisig, Markus Landthaler, Bertram Klinger, Nils Blüthgen	2017	41
9	Blood‐ and skin‐derived monocytes/macrophages respond to C3a but not to C3a(desArg) with a transient release of calcium via a pertussis toxin‐sensitive signal transduction pathway European Journal of Immunology ·Jörg Zwirner, Otto Götze, Alexander Moser, Anja Sieber, Gabriele Begemann, Alexander Kapp, Jörn Elsner, Thomas Werfel	1997	36
10	Analysis of impedance-based cellular growth assays Bioinformatics ·Franziska Witzel, Raphaela Fritsche‐Guenther, Nadine Lehmann, Anja Sieber, Nils Blüthgen	2015	34
11	CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin The Journal of Immunology ·Thomas Werfel, Jörg Zwirner, Marc Oppermann, Anja Sieber, Gerrit Begemann, W. Drommer, Alexander Kapp, Otto Götze	1996	31
12	Isoform-specific Ras signaling is growth factor dependent Molecular Biology of the Cell ·Fiona E. Hood, Bertram Klinger, Anna U. Newlaczyl, Anja Sieber, Mathurin Dorel, Simon P. Oliver, Judy M. Coulson, Nils Blüthgen	2019	24
13	Modelling signalling networks from perturbation data Bioinformatics ·Mathurin Dorel, Bertram Klinger, Torsten Groß, Anja Sieber, Anirudh Prahallad, Evert Bosdriesz, Lodewyk F.A. Wessels, Nils Blüthgen	2018	16
14	Reflection of neuroblastoma intratumor heterogeneity in the new OHC‐NB1 disease model International Journal of Cancer ·Theresa M. Thole, Joern Toedling, Annika Sprüssel, Sebastian Pfeil, Larissa Savelyeva, David Capper, Clemens Messerschmidt, Dieter Beule	2019	11
15	Mutation-specific effects of NRAS oncogenes in colorectal cancer cells Advances in Biological Regulation ·Natalia R. Kuhn, Bertram Klinger, Florian Uhlitz, Anja Sieber, Maria Rivera, Kathleen Klotz‐Noack, Iduna Fichtner, Jens Hoffmann	2020	7
16	Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance PLoS Computational Biology ·Mathurin Dorel, Bertram Klinger, Tommaso Mari, Joern Toedling, Eric Blanc, Clemens Messerschmidt, Michal Nadler-Holly, Matthias Ziehm	2021	7
17	Comparative Network Reconstruction using mixed integer programming Bioinformatics ·Evert Bosdriesz, Anirudh Prahallad, Bertram Klinger, Anja Sieber, Astrid R. Bosma, Rene Bernards, Nils Blüthgen, Lodewyk F.A. Wessels	2018	7
18	Identifying mutant-specific multi-drug combinations using comparative network reconstruction iScience ·Evert Bosdriesz, João M. Fernandes Neto, Anja Sieber, Rene Bernards, Nils Blüthgen, Lodewyk F.A. Wessels	2022	2
19	Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells Nature Communications ·Mirjam van Bentum, Bertram Klinger, Anja Sieber, Sheyda Naghiloo, Henrik Zauber, Nadine Lehmann, Mohamed Haji, Sylvia Niquet	2025	2
20	Modeling unveils sex differences of signaling networks in mouse embryonic stem cells Molecular Systems Biology ·Zeba Sultana, Mathurin Dorel, Bertram Klinger, Anja Sieber, Ilona Dunkel, Nils Blüthgen, Edda G. Schulz	2023	2

About Anja Sieber

Anja Sieber is a scholar working on Cancer Research, Molecular Biology, Oncology, Biophysics and Computational Theory and Mathematics, having authored 21 papers that have together received 1.5k indexed citations. Recurring topics across this work include Melanoma and MAPK Pathways (5 papers), Gene Regulatory Network Analysis (3 papers), Computational Drug Discovery Methods (3 papers), CRISPR and Genetic Engineering (2 papers), Cancer Genomics and Diagnostics (2 papers), Pluripotent Stem Cells Research (2 papers), Neuroblastoma Research and Treatments (2 papers) and Colorectal Cancer Treatments and Studies (2 papers). The work is most often cited by research in Cancer Research (181 citations), Molecular Biology (845 citations), Immunology (227 citations), Oncology (255 citations) and Biophysics (60 citations). Anja Sieber has collaborated with scholars based in Germany, Netherlands and United Kingdom. Frequent co-authors include Nils Blüthgen, Bertram Klinger, Mathew J. Garnett, Julio Sáez-Rodríguez, Florian Uhlitz, Martina Klünemann, Michaël Schubert, Sascha Sauer, Raphaela Fritsche‐Guenther and Franziska Witzel. Their work appears in journals such as Molecular Systems Biology, Bioinformatics, Nature Communications, Advances in Biological Regulation and European Journal of Immunology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Anja Sieber

Anja Sieber's Hit Papers

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All Works

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