A. Ruf

4.1k citations

38 papers · 3.5k · 2 hit papers · h-index 26

Impact in

Radiology, Nuclear Medicine and Imaging top 2%
- Monoclonal and Polyclonal Antibodies Research
Molecular Biology top 5%
- Glycosylation and Glycoproteins Research
- Plant biochemistry and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Protein Structure and Dynamics

Papers in

Molecular Biology 22
- Peroxisome Proliferator-Activated Receptors 4
- Enzyme function and inhibition 3
- Receptor Mechanisms and Signaling 3
- Biochemical and Molecular Research 3
- Protein Structure and Dynamics 3
Materials Chemistry 14
- Enzyme Structure and Function 14

Co-authors: M. Stihle (12 shared papers)Michael Hennig (10 shared papers)Jörg Benz (17 shared papers)Ralf Thoma (8 shared papers)Georg E. Schulz (3 shared papers)Gilbert de MURCIA (3 shared papers)Arne Christian Rufer (5 shared papers)Toon Laeremans (2 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (6 papers)Journal of Molecular Biology (4 papers)ChemMedChem (2 papers)Acta Crystallographica Section D Structural Biology (2 papers)CHIMIA International Journal for Chemistry (2 papers)
Partner nations: Switzerland United States Germany

In The Last Decade

A. Ruf

38 papers receiving 3.4k citations

A. Ruf's Hit Papers

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A general protocol for the generation of Nanobodies for structural biology 2014 · 638 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2014 Nature Protocols
2011 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by A. Ruf

Since Specialization

Citations

This map shows the geographic impact of A. Ruf's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by A. Ruf with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites A. Ruf more than expected).

Fields of papers citing papers by A. Ruf

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by A. Ruf. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by A. Ruf. The network helps show where A. Ruf may publish in the future.

Co-authors

The 25 scholars most cited alongside A. Ruf, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with A. Ruf Line = papers co-authored together A. Ruf links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 38 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose Proceedings of the National Academy of Sciences ·Claudia Ferrara, Sandra Grau, Peter Sondermann, Peter Brünker, Inja Waldhauer, Michael Hennig, A. Ruf, Arne Christian Rufer Hit paper breakdown →	2011	665
2	A general protocol for the generation of Nanobodies for structural biology Nature Protocols ·Els Pardon, Toon Laeremans, Sarah Triest, Søren G. F. Rasmussen, Alexandre Wohlkönig, A. Ruf, Serge Muyldermans, Wim G. J. Hol Hit paper breakdown →	2014	638
3	Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase Nature ·Ralf Thoma, Tanja Schulz‐Gasch, Brigitte D’Arcy, Jörg Benz, Johannes D. Aebi, Henrietta Dehmlow, Michael Hennig, M. Stihle	2004	318
4	Structural Basis of Proline-Specific Exopeptidase Activity as Observed in Human Dipeptidyl Peptidase-IV Structure ·Ralf Thoma, Bernd Löffler, M. Stihle, Walter Huber, A. Ruf, Michael Hennig	2003	210
5	Inhibitor and NAD+ Binding to Poly(ADP-ribose) Polymerase As Derived from Crystal Structures and Homology Modeling, Biochemistry ·A. Ruf, Gilbert de MURCIA, Georg E. Schulz	1998	184
6	Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1 Nature Communications ·Roger J. P. Dawson, Jörg Benz, Peter Stohler, Tim Tetaz, Sylwia Huber, D. Huegin, Pascal Pflimlin, Markus Georg Rudolph	2012	160
7	The mechanism of the elongation and branching reaction of Poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis Journal of Molecular Biology ·A. Ruf, Véronique Rolli, Gilbert de MURCIA, Georg E. Schulz	1998	148
8	A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Recruits PPARγ-Coactivator-1α, Prevents Triglyceride Accumulation, and Potentiates Insulin Signaling in Vitro Molecular Endocrinology ·Elke Burgermeister, Astride Schnoebelen, Angele Flament, Jörg Benz, M. Stihle, Bernard Gsell, Arne Christian Rufer, A. Ruf	2005	139
9	Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations Journal of Molecular Biology ·G. Schoch, Brigitte D’Arcy, M. Stihle, Dominique Burger, Jörg Benz, Ralf Thoma, A. Ruf +1 other	2009	110
10	Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes Bioorganic & Medicinal Chemistry Letters ·Agnes M. Benardeau, Jörg Benz, Alfred Binggeli, Markus Boehringer, Uwe Grether, Hans Hilpert, Bernd Kuhn, Hans Peter Märki	2009	94
11	X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann–La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing. Angewandte Chemie International Edition ·C. Lerner, A. Ruf, V. Gramlich, Birgit Masjost, Gerhard Zürcher, Roland Jakob‐Roetne, Edilio Borroni, François Diederich	2001	60
12	Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography Scientific Reports ·Sarah H. Shahmoradian, Esther H. R. Tsai, Ana Díaz, Manuel Guizar‐Sicairos, Jörg Raabe, Liz Spycher, Markus Britschgi, A. Ruf	2017	56
13	Real-time monitoring of binding events on a thermostabilized human A2A receptor embedded in a lipid bilayer by surface plasmon resonance Biochimica et Biophysica Acta (BBA) - Biomembranes ·Nicolas Bocquet, Josiane Kohler, Melanie N. Hug, Eric A. Kusznir, Arne Christian Rufer, Roger J. P. Dawson, Michael Hennig, A. Ruf	2015	55
14	Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity Organic & Biomolecular Chemistry ·C. Lerner, Birgit Masjost, A. Ruf, V. Gramlich, Roland Jakob‐Roetne, Gerhard Zürcher, Edilio Borroni, François Diederich	2002	53
15	Structure of the Human Fatty Acid Synthase KS–MAT Didomain as a Framework for Inhibitor Design Journal of Molecular Biology ·Jörg Benz, Bernard Gsell, Michael Hennig, A. Ruf, M. Stihle, Ralf Thoma, Markus Georg Rudolph +1 other	2010	53
16	X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity Angewandte Chemie ·C. Lerner, A. Ruf, V. Gramlich, Birgit Masjost, Gerhard Zürcher, Roland Jakob‐Roetne, Edilio Borroni, François Diederich	2001	49
17	Tyramine fragment binding to BACE-1 Bioorganic & Medicinal Chemistry Letters ·A. Kuglstatter, Martin Ståhl, Jens‐Uwe Peters, Walter Huber, M. Stihle, Daniel Schlatter, Jörg Benz, A. Ruf	2008	47
18	Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry ACS Chemical Biology ·Dragana Cubrilovic, Wolfgang J. Haap, Konstantin Barylyuk, A. Ruf, Martin Badertscher, Marcel Gubler, Tim Tetaz, Jörg Benz	2013	47
19	Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors ChemMedChem ·Michel Dietz, Bernd Kuhn, Hans Peter Maerki, Peter G. HARTMAN, A. Ruf, Jörg Benz, Uwe Grether, Matthew B. Wright +1 other	2012	43
20	Enhancing the Stability and Solubility of the Glucocorticoid Receptor Ligand-Binding Domain by High-Throughput Library Screening Journal of Molecular Biology ·Tobias Seitz, Ralf Thoma, G. Schoch, M. Stihle, Jörg Benz, Brigitte D’Arcy, Andrea Wiget, A. Ruf	2010	42

About A. Ruf

A. Ruf is a scholar working on Molecular Biology, Materials Chemistry, Oncology, Sensory Systems and Computational Theory and Mathematics, having authored 38 papers that have together received 3.5k indexed citations. Recurring topics across this work include Enzyme Structure and Function (14 papers), Peroxisome Proliferator-Activated Receptors (4 papers), Enzyme function and inhibition (3 papers), Computational Drug Discovery Methods (3 papers), Cholesterol and Lipid Metabolism (3 papers), Receptor Mechanisms and Signaling (3 papers), Biochemical and Molecular Research (3 papers) and Protein Structure and Dynamics (3 papers). The work is most often cited by research in Radiology, Nuclear Medicine and Imaging (604 citations), Molecular Biology (1.6k citations), Sensory Systems (111 citations), Oncology (396 citations) and Computational Theory and Mathematics (253 citations). A. Ruf has collaborated with scholars based in Switzerland, United States and Germany. Frequent co-authors include M. Stihle, Michael Hennig, Jörg Benz, Ralf Thoma, Georg E. Schulz, Gilbert de MURCIA, Arne Christian Rufer, Toon Laeremans, Jan Steyaert and Søren G. F. Rasmussen. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Molecular Biology, ChemMedChem, Acta Crystallographica Section D Structural Biology and CHIMIA International Journal for Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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