A. Ruf

4.0k citations

36 papers · 3.3k · 2 hit papers · h-index 26

Impact in

Radiology, Nuclear Medicine and Imaging top 1%
- Monoclonal and Polyclonal Antibodies Research
Molecular Biology top 5%
- Glycosylation and Glycoproteins Research
- Plant biochemistry and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Protein purification and stability

Papers in

Molecular Biology 25
- Receptor Mechanisms and Signaling 6
- Peroxisome Proliferator-Activated Receptors 4
- Protein Structure and Dynamics 3
Physiology 5
- Adipose Tissue and Metabolism 4

Co-authors: M. Stihle (12 shared papers)Michael Hennig (10 shared papers)Jörg Benz (17 shared papers)Georg E. Schulz (2 shared papers)Ralf Thoma (8 shared papers)Arne C. Rufer (5 shared papers)Walter Huber (8 shared papers)Gilbert de Murcia (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (6 papers)Journal of Molecular Biology (4 papers)CHIMIA International Journal for Chemistry (2 papers)ChemMedChem (2 papers)Acta Crystallographica Section D Structural Biology (2 papers)
Partner nations: Switzerland United States Germany

In The Last Decade

A. Ruf

36 papers receiving 3.2k citations

A. Ruf's Hit Papers

align trajectories log scale

A general protocol for the generation of Nanobodies for structural biology 2014 · 589 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2014 Nature Protocols
2011 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by A. Ruf

Since Specialization

Citations

This map shows the geographic impact of A. Ruf's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by A. Ruf with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites A. Ruf more than expected).

Fields of papers citing papers by A. Ruf

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by A. Ruf. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by A. Ruf. The network helps show where A. Ruf may publish in the future.

Co-authors

The 25 scholars most cited alongside A. Ruf, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with A. Ruf Line = papers co-authored together A. Ruf links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 36 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose Proceedings of the National Academy of Sciences ·Claudia Ferrara, Sandra Grau, Christiane Jäger, Peter Sondermann, Peter Brünker, Inja Waldhauer, Michael Hennig, A. Ruf, Arne C. Rufer, M. Stihle, Pablo Umaña, Jörg Benz Hit paper breakdown →	2011	626
2	A general protocol for the generation of Nanobodies for structural biology Nature Protocols ·Els Pardon, Toon Laeremans, Sarah Triest, Søren G. F. Rasmussen, Alexandre Wohlkönig, A. Ruf, Serge Muyldermans, Wim G. J. Hol, Brian K. Kobilka, Jan Steyaert Hit paper breakdown →	2014	589
3	Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase Nature ·Ralf Thoma, Tanja Schulz‐Gasch, Brigitte D’Arcy, Jörg Benz, Johannes D. Aebi, Henrietta Dehmlow, Michael Hennig, M. Stihle, A. Ruf	2004	308
4	Structural Basis of Proline-Specific Exopeptidase Activity as Observed in Human Dipeptidyl Peptidase-IV Structure ·Ralf Thoma, Bernd Löffler, M. Stihle, Walter Huber, A. Ruf, Michael Hennig	2003	203
5	Inhibitor and NAD⁺ Binding to Poly(ADP-ribose) Polymerase As Derived from Crystal Structures and Homology Modeling^, Biochemistry ·A. Ruf, Gilbert de Murcia, Georg E. Schulz	1998	183
6	Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1 Nature Communications ·Roger Dawson, Jörg Benz, Peter Stohler, Tim Tetaz, Catherine Joseph, Sylwia Huber, Georg H. Schmid, Daniela Hügin, Pascal Pflimlin, (unknown), M.G. Rudolph, Michael Hennig, A. Ruf	2012	154
7	The mechanism of the elongation and branching reaction of Poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis Journal of Molecular Biology ·A. Ruf, Véronique Rolli, Gilbert de Murcia, Georg E. Schulz	1998	147
8	A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Recruits PPARγ-Coactivator-1α, Prevents Triglyceride Accumulation, and Potentiates Insulin Signaling in Vitro Molecular Endocrinology ·Elke Burgermeister, Astride Schnoebelen, Angele Flament, Jörg Benz, M. Stihle, Bernard Gsell, Arne C. Rufer, A. Ruf, Bernd Kuhn, Hans Peter Märki, Jacques Mizrahi, E Seböková, Eric J. Niesor, Markus Meyer	2005	133
9	Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations Journal of Molecular Biology ·G. Schoch, Brigitte D’Arcy, M. Stihle, Dominique Burger, Dominik Bär, Jörg Benz, Ralf Thoma, A. Ruf	2009	107
10	Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes Bioorganic & Medicinal Chemistry Letters ·Agnès Bénardeau, Jörg Benz, Alfred Binggeli, Denise Blum, Markus Boehringer, Uwe Grether, Hans Hilpert, Bernd Kuhn, Hans Peter Märki, Markus Meyer, Kurt Püntener, S. Raab, A. Ruf, Daniel Schlatter, Peter Mohr	2009	88
11	X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann–La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing. Angewandte Chemie International Edition ·C. Lerner, A. Ruf, Völker Gramlich, B. Masjost, G. Zürcher, Roland Jakob‐Roetne, Edilio Borroni, François Diederich	2001	59
12	Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography Scientific Reports ·Sarah H. Shahmoradian, Esther H. R. Tsai, Ana Díaz, Manuel Guizar‐Sicairos, Jörg Raabe, Liz Spycher, Markus Britschgi, A. Ruf, Henning Stahlberg, Mirko Holler	2017	53
13	Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity Organic & Biomolecular Chemistry ·C. Lerner, B. Masjost, A. Ruf, Völker Gramlich, Roland Jakob‐Roetne, G. Zürcher, Edilio Borroni, François Diederich	2002	52
14	Structure of the Human Fatty Acid Synthase KS–MAT Didomain as a Framework for Inhibitor Design Journal of Molecular Biology ·(unknown), Jörg Benz, Bernard Gsell, Michael Hennig, A. Ruf, M. Stihle, Ralf Thoma, M.G. Rudolph	2010	51
15	Real-time monitoring of binding events on a thermostabilized human A2A receptor embedded in a lipid bilayer by surface plasmon resonance Biochimica et Biophysica Acta (BBA) - Biomembranes ·Nicolas Bocquet, Josiane Kohler, Melanie N. Hug, Eric A. Kusznir, Arne C. Rufer, Roger Dawson, Michael Hennig, A. Ruf, Walter Huber, Sylwia Huber	2015	50
16	X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity Angewandte Chemie ·C. Lerner, A. Ruf, Völker Gramlich, B. Masjost, G. Zürcher, Roland Jakob‐Roetne, Edilio Borroni, François Diederich	2001	49
17	Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry ACS Chemical Biology ·Dragana Cubrilovic, Wolfgang Haap, Konstantin Barylyuk, A. Ruf, Martin Badertscher, Marcel Gubler, Tim Tetaz, Catherine Joseph, Jörg Benz, Renato Zenobi	2013	46
18	Tyramine fragment binding to BACE-1 Bioorganic & Medicinal Chemistry Letters ·A. Kuglstatter, Martin Ståhl, Jens‐Uwe Peters, Walter Huber, M. Stihle, Daniel Schlatter, Jörg Benz, A. Ruf, Doris Roth, Thilo Enderle, Michael Hennig	2008	44
19	Enhancing the Stability and Solubility of the Glucocorticoid Receptor Ligand-Binding Domain by High-Throughput Library Screening Journal of Molecular Biology ·Tobias Seitz, Ralf Thoma, G. Schoch, M. Stihle, Jörg Benz, Brigitte D’Arcy, Andrea Wiget, A. Ruf, Michael Hennig, Reinhard Sterner	2010	42
20	Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery Topics in current chemistry ·Michael Hennig, A. Ruf, Walter Huber	2011	40

About A. Ruf

A. Ruf is a scholar working on Molecular Biology, Physiology, Biochemistry, Materials Chemistry and Computational Theory and Mathematics, having authored 36 papers that have together received 3.3k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (6 papers), Enzyme Structure and Function (5 papers), Monoclonal and Polyclonal Antibodies Research (4 papers), Adipose Tissue and Metabolism (4 papers), Peroxisome Proliferator-Activated Receptors (4 papers), Computational Drug Discovery Methods (4 papers), Biochemical Acid Research Studies (3 papers) and Protein Structure and Dynamics (3 papers). The work is most often cited by research in Radiology, Nuclear Medicine and Imaging (856 citations), Molecular Biology (2.3k citations), Immunology (511 citations), Structural Biology (37 citations) and Oncology (610 citations). A. Ruf has collaborated with scholars based in Switzerland, United States and Germany. Frequent co-authors include M. Stihle, Michael Hennig, Jörg Benz, Georg E. Schulz, Ralf Thoma, Arne C. Rufer, Walter Huber, Gilbert de Murcia, Toon Laeremans and Jan Steyaert. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Molecular Biology, CHIMIA International Journal for Chemistry, ChemMedChem and Acta Crystallographica Section D Structural Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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A. Ruf's Hit Papers

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