Tse‐I Lin

1.4k citations

39 papers · 1.2k · h-index 17

Impact in

Hepatology top 1%
- Hepatitis C virus research
Organic Chemistry top 10%
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles

Papers in

Hepatology 22
- Hepatitis C virus research 22
Epidemiology 12
- Hepatitis B Virus Studies 9
- Liver Disease Diagnosis and Treatment 3

Co-authors: Oliver Lenz (9 shared papers)Pierre Raboisson (11 shared papers)Kenneth Simmen (7 shared papers)Gregory C. Fanning (6 shared papers)Thierry Verbinnen (4 shared papers)Herman de Kock (5 shared papers)Lotta Vrang (4 shared papers)Michael Edlund (4 shared papers)
Journals: Journal of Hepatology (9 papers)Bioorganic & Medicinal Chemistry Letters (9 papers)Journal of Medicinal Chemistry (6 papers)Antimicrobial Agents and Chemotherapy (3 papers)Angewandte Chemie International Edition (3 papers)
Partner nations: Belgium Sweden United States

In The Last Decade

Tse‐I Lin

37 papers receiving 1.1k citations

Peers

Countries citing papers authored by Tse‐I Lin

Since Specialization

Citations

This map shows the geographic impact of Tse‐I Lin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tse‐I Lin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tse‐I Lin more than expected).

Fields of papers citing papers by Tse‐I Lin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tse‐I Lin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tse‐I Lin. The network helps show where Tse‐I Lin may publish in the future.

Co-authors

The 25 scholars most cited alongside Tse‐I Lin, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Tse‐I Lin Line = papers co-authored together Tse‐I Lin links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 39 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435 Antimicrobial Agents and Chemotherapy ·Oliver Lenz, Thierry Verbinnen, Tse‐I Lin, Leen Vijgen, Maxwell D. Cummings, Jimmy Lindberg, Jan Martin Berke, Pascale Dehertogh	2010	199
2	In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor Antimicrobial Agents and Chemotherapy ·Tse‐I Lin, Oliver Lenz, Gregory C. Fanning, Thierry Verbinnen, Frédéric Delouvroy, Annick Scholliers, Katrien Vermeiren, Åsa Rosenquist	2009	166
3	Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350 Bioorganic & Medicinal Chemistry Letters ·Pierre Raboisson, Herman de Kock, Åsa Rosenquist, Lourdes Salvador Oden, Tse‐I Lin, Natalie Roue, Horst Wähling, Kristina Wickström	2008	113
4	Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target Angewandte Chemie International Edition ·Maxwell D. Cummings, Jimmy Lindberg, Tse‐I Lin, Herman de Kock, Oliver Lenz, Elisabet Lilja, Sara Felländer, Vera Baraznenok	2010	88
5	Tracking the Evolution of MultipleIn VitroHepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing Journal of Virology ·Thierry Verbinnen, Herwig G. Van Marck, Ina Vandenbroucke, Leen Vijgen, Marijke Claes, Tse‐I Lin, Kenneth Simmen, Johan H. Neyts	2010	61
6	1,5-Benzodiazepine inhibitors of HCV NS5B polymerase Bioorganic & Medicinal Chemistry Letters ·David C. McGowan, Origène Nyanguile, Maxwell D. Cummings, Sandrine Vendeville, Koen Vandyck, Walter M.M. Van den Broeck, Carlo Boutton, Hendrik L. De Bondt	2009	52
7	2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase Journal of Medicinal Chemistry ·Tim H. M. Jonckers, Tse‐I Lin, Christophe Buyck, Sophie Lachau‐Durand, Koen Vandyck, Steven Van Hoof, Leen A. M. Vandekerckhove, Lili Hu	2010	51
8	Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH) PLoS ONE ·Xuan G. Luong, Sarah Stevens, Andreas Jekle, Tse‐I Lin, Kusum Gupta, Dinah Misner, Sushmita M. Chanda, Sucheta Mukherjee	2020	44
9	Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors Gastroenterology ·Hisashi Ishida, Oliver Lenz, Tse‐I Lin, Origène Nyanguile, Kenny Simmen, Richard B. Pyles, Nigel Bourne, MinKyung Yi	2008	42
10	Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase Journal of Medicinal Chemistry ·Tim H. M. Jonckers, Koen Vandyck, Leen A. M. Vandekerckhove, Lili Hu, Abdellah Tahri, Steven Van Hoof, Tse‐I Lin, Leen Vijgen	2013	40
11	Structure‐Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties Angewandte Chemie International Edition ·Maxwell D. Cummings, Tse‐I Lin, Lili Hu, Abdellah Tahri, David C. McGowan, Katie Amssoms, Stefaan Last, Benoit Devogelaere	2012	39
12	Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055 Bioorganic & Medicinal Chemistry Letters ·Sandrine Vendeville, Tse‐I Lin, Lili Hu, Abdellah Tahri, David C. McGowan, Maxwell D. Cummings, Katie Amssoms, Stefaan Last	2012	34
13	Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase Journal of Medicinal Chemistry ·Maxwell D. Cummings, Tse‐I Lin, Lili Hu, Abdellah Tahri, David C. McGowan, Katie Amssoms, Stefaan Last, Benoit Devogelaere	2013	31
14	Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors Bioorganic & Medicinal Chemistry Letters ·Pierre Raboisson, Tse‐I Lin, Herman de Kock, Sandrine Vendeville, Wim Van de Vreken, David C. McGowan, Abdellah Tahri, Lili Hu	2008	24
15	Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2′-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3′-5′-Cyclic Phosphate Ester Prodrug of 2′-Deoxy-2′-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition Journal of Medicinal Chemistry ·Tim H. M. Jonckers, Abdellah Tahri, Leen Vijgen, Jan Martin Berke, Sophie Lachau‐Durand, Bart Stoops, Jan Snoeys, Lotke Tambuyzer	2016	23
16	Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents Bioorganic & Medicinal Chemistry Letters ·Anna Karin Belfrage, Horst Wähling, Charlotta Lindquist, Susana Ayesa, Pia Kahnberg, Mikael Pelcman, Kurt Benkestock, Tatiana Agback	2010	18
17	Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors Bioorganic & Medicinal Chemistry Letters ·Sandrine Vendeville, Herman de Kock, Tse‐I Lin, Dmitry M. Antonov, Björn Classon, Susana Ayesa, Per-Ola Johansson, Pia Kahnberg	2008	17
18	Discovery of 4′-azido-2′-deoxy-2′-C-methyl cytidine and prodrugs thereof: A potent inhibitor of Hepatitis C virus replication Bioorganic & Medicinal Chemistry Letters ·Genadiy Kalayanov, Anna Winqvist, Pedro Guilherme Lacerda Ferreira Pinho, Christian J. Sund, Xiao-Xiong Zhou, Horst Wähling, Anna Karin Belfrage, Michael Pelcman	2012	16
19	Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series Bioorganic & Medicinal Chemistry Letters ·David C. McGowan, Sandrine Vendeville, Tse‐I Lin, Abdellah Tahri, Lili Hu, Maxwell D. Cummings, Katie Amssoms, Jan Martin Berke	2012	14
20	Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Pierre Raboisson, Oliver Lenz, Tse‐I Lin, Dominique L. N. G. Surleraux, Sarvajit Chakravarty, Annick Scholliers, Katrien Vermeiren, Frédéric Delouvroy	2007	13

About Tse‐I Lin

Tse‐I Lin is a scholar working on Hepatology, Epidemiology, Molecular Biology, Computational Theory and Mathematics and Renewable Energy, Sustainability and the Environment, having authored 39 papers that have together received 1.2k indexed citations. Recurring topics across this work include Hepatitis C virus research (22 papers), Hepatitis B Virus Studies (9 papers), RNA Interference and Gene Delivery (3 papers), Liver Disease Diagnosis and Treatment (3 papers), Mitochondrial Function and Pathology (2 papers), Computational Drug Discovery Methods (2 papers), Chemical Synthesis and Analysis (1 paper) and Metalloenzymes and iron-sulfur proteins (1 paper). The work is most often cited by research in Hepatology (659 citations), Organic Chemistry (223 citations), Computational Theory and Mathematics (108 citations), Infectious Diseases (70 citations) and Epidemiology (72 citations). Tse‐I Lin has collaborated with scholars based in Belgium, Sweden and United States. Frequent co-authors include Oliver Lenz, Pierre Raboisson, Kenneth Simmen, Gregory C. Fanning, Thierry Verbinnen, Herman de Kock, Lotta Vrang, Michael Edlund, Katrien Vermeiren and Annick Scholliers. Their work appears in journals such as Journal of Hepatology, Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Antimicrobial Agents and Chemotherapy and Angewandte Chemie International Edition.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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