Tim Crook

15.0k citations

122 papers · 11.2k · 4 hit papers · h-index 54

Impact in

Oncology top 0.2%
- Cancer-related Molecular Pathways
Cancer Research top 0.5%
- Cancer, Hypoxia, and Metabolism

Papers in

Molecular Biology 68
- Epigenetics and DNA Methylation 22
- RNA modifications and cancer 14
- Ubiquitin and proteasome pathways 10
- Cancer-related gene regulation 10
Oncology 57
- Cancer-related Molecular Pathways 40

Co-authors: Milena Gasco (19 shared papers)Karen H. Vousden (11 shared papers)Nelofer Syed (31 shared papers)John Tidy (8 shared papers)Xin Lü (8 shared papers)Daniele Bergamaschi (6 shared papers)Martin J. Allday (9 shared papers)Ornella Garrone (9 shared papers)
Journals: British Journal of Cancer (12 papers)Oncogene (10 papers)Blood (4 papers)Journal of Clinical Oncology (4 papers)Cell Death and Disease (4 papers)
Partner nations: United Kingdom Italy United States

In The Last Decade

Tim Crook

118 papers receiving 11.0k citations

Tim Crook's Hit Papers

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DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis 2006 · 1.1k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2006 Cell
2001 Molecular Cell
2000 Nature Genetics
1999 Cell

Peers

Countries citing papers authored by Tim Crook

Since Specialization

Citations

This map shows the geographic impact of Tim Crook's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tim Crook with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tim Crook more than expected).

Fields of papers citing papers by Tim Crook

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tim Crook. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tim Crook. The network helps show where Tim Crook may publish in the future.

Co-authors

The 25 scholars most cited alongside Tim Crook, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Tim Crook Line = papers co-authored together Tim Crook links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 122 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis Cell ·Diane Crighton, Simon Wilkinson, Jim O’Prey, Nelofer Syed, Paul Smith, Paul R. Harrison, Milena Gasco, Ornella Garrone, Tim Crook, Kevin M. Ryan Hit paper breakdown →	2006	1099
2	Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types Cell ·Tony G. Willis, Dalal Jadayel, Ming‐Qing Du, Huaizheng Peng, Amanda R. Perry, Munah Abdul-Rauf, Helen P. Price, Loraine Karran, Oluwatosin Majekodunmi, Iwona Włodarska, Langxing Pan, Tim Crook, Rifat Hamoudi, Peter G. Isaacson, Martin J.S. Dyer Hit paper breakdown →	1999	520
3	ASPP Proteins Specifically Stimulate the Apoptotic Function of p53 Molecular Cell ·Yardena Samuels-Lev, Daniel O’Connor, Daniele Bergamaschi, Giuseppe Trigiante, Jung-Kuang Hsieh, Shan Zhong, Isabelle Campargue, Louie Naumovski, Tim Crook, Xin Lü Hit paper breakdown →	2001	518
4	A common polymorphism acts as an intragenic modifier of mutant p53 behaviour Nature Genetics ·María C. Marín, Christine A. Jost, Louise Brooks, Meredith S. Irwin, Jenny O’Nions, John Tidy, (unknown), Jane McGregor, Catherine Harwood, Işık G. Yuluğ, Karen H. Vousden, Martin J. Allday, Barry A. Gusterson, Shuntaro Ikawa, Philip W. Hinds, Tim Crook, William G. Kaelin Hit paper breakdown →	2000	441
5	Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation Cell ·Tim Crook, Karen H. Vousden, John Tidy	1991	434
6	p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis Cancer Cell ·Daniele Bergamaschi, Milena Gasco, Louise Hiller, Alexandra Sullivan, Nelofer Syed, Giuseppe Trigiante, Işık G. Yuluğ, Marco Merlano, Gianmauro Numico, Alberto Comino, Marlene Attard, Olivier Reelfs, Barry A. Gusterson, Alexandra Bell, Victoria J. Heath, Mahvash Tavassoli, Paul J. Farrell, Paul Smith, Xin Lü, Tim Crook	2003	357
7	Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer International Journal of Cancer ·Barbara Delage, Dean A. Fennell, Linda Nicholson, Iain A. McNeish, Nicholas R. Lemoine, Tim Crook, Peter W. Szlosarek	2010	351
8	The p53 pathway in breast cancer Breast Cancer Research ·Milena Gasco, Shukri K. Shami, Tim Crook	2002	310
9	iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human Nature Genetics ·Daniele Bergamaschi, Yardena Samuels, Nigel J. O’Neil, Giuseppe Trigiante, Tim Crook, Jung-Kuang Hsieh, Daniel O’Connor, Shan Zhong, Isabelle Campargue, Matthew L. Tomlinson, Patricia E. Kuwabara, Xin Lü	2003	298
10	Yes-associated protein (YAP) functions as a tumor suppressor in breast Cell Death and Differentiation ·Ming Yuan, V Tomlinson, Romain Lara, Deborah L. Holliday, Claude Chelala, Takeshi Harada, Rathi Gangeswaran, C Manson-Bishop, Paul J. Smith, Safia Danovi, Olivier E. Pardo, Tim Crook, Charles A. Mein, Nicholas R. Lemoine, J. Louise Jones, Soumalee Basu	2008	273
11	Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours The Lancet ·Tim Crook, C. David Wrede, John Tidy, Karen H. Vousden, W. P. Mason, David J. Evans	1992	258
12	A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer Cancer Cell ·Javier E. Girardini, Marco Napoli, Silvano Piazza, Alessandra Rustighi, Carolina Marotta, Enrico Radaelli, Valeria Capaci, Lee B. Jordan, Philip Quinlan, Alastair Thompson, Miguel Mano, Antonio Rosato, Tim Crook, Eugenio Scanziani, Anthony R. Means, Guillermina Lozano, Claudio Schneider, Giannino Del Sal	2011	237
13	Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo Oncogene ·Alexandra Sullivan, Nelofer Syed, Milena Gasco, Daniele Bergamaschi, Giuseppe Trigiante, Marlene Attard, Louise Hiller, Paul J. Farrell, Paul Smith, Xin Lü, Tim Crook	2004	214
14	iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53 Nature Genetics ·Daniele Bergamaschi, Yardena Samuels, Alexandra Sullivan, Marketa Zvelebil, Hilde Breyssens, Andrea Bisso, Giannino Del Sal, Nelofer Syed, Paul Smith, Milena Gasco, Tim Crook, Xin Lü	2006	212
15	Continued expression of HPV‐16 E7 protein is required for maintenance of the transformed phenotype of cells co‐transformed by HPV‐16 plus EJ‐ras. The EMBO Journal ·Tim Crook, Jay P. Morgenstern, L. Crawford, Lawrence Banks	1989	198
16	ASPP1 and ASPP2: Common Activators of p53 Family Members Molecular and Cellular Biology ·Daniele Bergamaschi, Yardena Samuels, Boquan Jin, Sai Duraisingham, Tim Crook, Xin Lü	2004	190
17	Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation Journal of Virology ·R. Davies, Ray Hicks, Tim Crook, Jessica P Morris, Karen H. Vousden	1993	175
18	Identification of CDK10 as an Important Determinant of Resistance to Endocrine Therapy for Breast Cancer Cancer Cell ·Elizabeth Iorns, Nicholas C. Turner, Richard Elliott, Nelofer Syed, Ornella Garrone, Milena Gasco, Andrew Tutt, Tim Crook, Christopher J. Lord, Alan Ashworth	2008	174
19	High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)? Oncogene ·Tim Crook, John M. Nicholls, Louise Brooks, Jenny O’Nions, Martin J. Allday	2000	162
20	Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells Cell Death and Disease ·Ghada Ajabnoor, Tim Crook, Helen M. Coley	2012	155

About Tim Crook

Tim Crook is a scholar working on Molecular Biology, Oncology, Genetics, Epidemiology and Cancer Research, having authored 122 papers that have together received 11.2k indexed citations. Recurring topics across this work include Cancer-related Molecular Pathways (40 papers), Epigenetics and DNA Methylation (22 papers), Cancer Research and Treatments (16 papers), RNA modifications and cancer (14 papers), Cervical Cancer and HPV Research (13 papers), Virus-based gene therapy research (11 papers), Ubiquitin and proteasome pathways (10 papers) and Cancer-related gene regulation (10 papers). The work is most often cited by research in Oncology (4.7k citations), Cancer Research (2.0k citations), Biotechnology (1.2k citations), Molecular Biology (5.9k citations) and Epidemiology (2.2k citations). Tim Crook has collaborated with scholars based in United Kingdom, Italy and United States. Frequent co-authors include Milena Gasco, Karen H. Vousden, Nelofer Syed, John Tidy, Xin Lü, Daniele Bergamaschi, Martin J. Allday, Ornella Garrone, Paul Smith and Giuseppe Trigiante. Their work appears in journals such as British Journal of Cancer, Oncogene, Blood, Journal of Clinical Oncology and Cell Death and Disease.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Tim Crook

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Tim Crook

Tim Crook's Hit Papers

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About Tim Crook

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