Stuart E. Pearson

1.1k citations

21 papers · 956 · h-index 13

Impact in

Computational Theory and Mathematics top 5%
- Computational Drug Discovery Methods
Cancer Research top 10%
- Cancer, Hypoxia, and Metabolism

Papers in

Organic Chemistry 13
- Quinazolinone synthesis and applications 5
- Synthesis and biological activity 5
- Synthesis of heterocyclic compounds 2
- Catalytic Cross-Coupling Reactions 2
Pulmonary and Respiratory Medicine 4
- Lung Cancer Treatments and Mutations 3

Co-authors: James S. Scott (5 shared papers)Santosh Nandan (1 shared paper)Ryan D. R. Greenwood (3 shared papers)F. Geoffrey N. Cloke (2 shared papers)Stephen Caddick (2 shared papers)Kevin Hudson (2 shared papers)Richard A. Norman (1 shared paper)Alessandro T. Caputo (1 shared paper)
Journals: Journal of Medicinal Chemistry (8 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Bioorganic & Medicinal Chemistry (2 papers)Synthesis (2 papers)MedChemComm (1 paper)
Partner nations: United Kingdom Sweden China

In The Last Decade

Stuart E. Pearson

21 papers receiving 914 citations

Peers

Countries citing papers authored by Stuart E. Pearson

Since Specialization

Citations

This map shows the geographic impact of Stuart E. Pearson's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stuart E. Pearson with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stuart E. Pearson more than expected).

Fields of papers citing papers by Stuart E. Pearson

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stuart E. Pearson. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stuart E. Pearson. The network helps show where Stuart E. Pearson may publish in the future.

Co-authors

The 25 scholars most cited alongside Stuart E. Pearson, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Stuart E. Pearson Line = papers co-authored together Stuart E. Pearson links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 21 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Discovery of 4-Amino- N -[(1 S )-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases Journal of Medicinal Chemistry ·Matt Addie, Peter G. Ballard, David Buttar, Claire Crafter, Gordon S. Currie, Barry R. Davies, J.E. Debreczeni, Hannah Dry	2013	203
2	AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1 -Mutant Breast Tumors in Preclinical Models Cancer Research ·Hazel M. Weir, Robert Hart Bradbury, Mandy Lawson, Alfred A. Rabow, David Buttar, Rowena J. Callis, Jon Curwen, Peter G. Ballard	2016	161
3	Optimization of a Novel Binding Motif to ( E )-3-(3,5-Difluoro-4-((1 R ,3 R )-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1 H -pyrido[3,4- b ]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist Journal of Medicinal Chemistry ·Chris De Savi, Robert Hart Bradbury, Alfred A. Rabow, Richard A. Norman, David M. Andrews, Peter G. Ballard, David Buttar, Rowena J. Callis	2015	150
4	Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation Journal of Medicinal Chemistry ·Richard A. Ward, C. Brassington, Alexander L. Breeze, Alessandro T. Caputo, Susan E. Critchlow, Gareth M. Davies, Louise Goodwin, Giles Hassall	2012	148
5	Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors Journal of Medicinal Chemistry ·Jason G. Kettle, Rana Anjum, Evan Barry, Deepa Bhavsar, Crystal Brown, Scott Boyd, Andrew D. Campbell, Kristin Goldberg	2018	56
6	Development of a practical Buchwald–Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst Organic & Biomolecular Chemistry ·Mark J. Cawley, F. Geoffrey N. Cloke, Richard J. Fitzmaurice, Stuart E. Pearson, James S. Scott, Stephen Caddick	2008	41
7	Inhibitors of epidermal growth factor receptor tyrosine kinase: Optimisation of potency and in vivo pharmacokinetics Bioorganic & Medicinal Chemistry Letters ·Peter G. Ballard, Robert Hart Bradbury, Craig Steven Harris, Laurent François Hennequin, Mark D. Hickinson, Jason G. Kettle, Jane Kendrew, Teresa C. M. Klinowska	2006	30
8	Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2 Journal of Medicinal Chemistry ·Kurt G. Pike, Jeff J. Morris, Linette Ruston, Sarah L. Pass, Ryan D. R. Greenwood, Emma J. Williams, Julie Demeritt, Janet D. Culshaw	2015	27
9	Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors ACS Medicinal Chemistry Letters ·Bernard C. Barlaam, Elaine B. Cadogan, Andrew D. Campbell, Nicola Colclough, Allan P. Dishington, Stephen T. Durant, Kristin Goldberg, Lorraine A. Hassall	2018	25
10	Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase Bioorganic & Medicinal Chemistry Letters ·Peter G. Ballard, Bernard C. Barlaam, Robert Hart Bradbury, Allan P. Dishington, Laurent François Hennequin, D. Mark Hickinson, Ian Hollingsworth, Jason G. Kettle	2007	24
11	A Practical, Efficient Synthesis of 5-Amino-7-azaindole Synthesis ·Stuart E. Pearson, Santosh Nandan	2005	20
12	Studies on Pd/imidazolium salt protocols for aminations of aryl bromides and iodides using lithium hexamethyldisilazide (LHMDS) Journal of Organometallic Chemistry ·Israel Conesa Lerma, Mark J. Cawley, F. Geoffrey N. Cloke, Katherine Arentsen, James S. Scott, Stuart E. Pearson, John D. Hayler, Stephen Caddick	2005	18
13	A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase Bioorganic & Medicinal Chemistry Letters ·Bernard C. Barlaam, Peter G. Ballard, Robert Hart Bradbury, Richard Ducray, Hervé Germain, D. Mark Hickinson, Kevin Hudson, Jason G. Kettle	2007	18
14	Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors Bioorganic & Medicinal Chemistry ·Sébastien L. Degorce, Anna Aagaard, Rana Anjum, Iain A. Cumming, C. R. Diène, Charlene Fallan, Tony Johnson, Karl‐Johan Leuchowius	2020	8
15	Identification and optimisation of a series of N-(4-anilino-2-pyridyl)acetamide activin receptor-like kinase 1 (ALK1) inhibitors MedChemComm ·Frederick W. Goldberg, Paula Daunt, Stuart E. Pearson, Ryan D. R. Greenwood, Matthew Grist, J.E. Debreczeni	2016	7
16	Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors Bioorganic & Medicinal Chemistry ·Iain A. Cumming, Sébastien L. Degorce, Anna Aagaard, Erin L. Braybrooke, Nichola L. Davies, C. R. Diène, Andrew J. Eatherton, Hannah R. Felstead	2022	5
17	Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions Synthesis ·Stuart E. Pearson, Shaun M. Fillery, Kristin Goldberg, Julie Demeritt, Jonathan Finlayson, Anil S. Patel +1 other	2018	4
18	Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations Journal of Medicinal Chemistry ·William McCoull, Clare Thomson, Erin L. Braybrooke, Nicola Colclough, Miguel Angel Cortes Gonzalez, Sabina C. Cosulich, Nichola L. Davies, Nicolas Floc’h	2025	4
19	The ‘Eenie–Meenie reaction’. Displacement reactions of bisanilinopyrimidines Tetrahedron Letters ·Stuart E. Pearson, Robin D. Wood	2002	3
20	Optimization of Potent, Efficacious, Selective and Blood–Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations Journal of Medicinal Chemistry ·Clare Thomson, Erin L. Braybrooke, Nicola Colclough, Nichola L. Davies, Nicolas Floc’h, Ryan D. R. Greenwood, Carine M. Guerot, David Hargreaves	2024	2

About Stuart E. Pearson

Stuart E. Pearson is a scholar working on Organic Chemistry, Pulmonary and Respiratory Medicine, Oncology, Cancer Research and Computational Theory and Mathematics, having authored 21 papers that have together received 956 indexed citations. Recurring topics across this work include Quinazolinone synthesis and applications (5 papers), Synthesis and biological activity (5 papers), Lung Cancer Treatments and Mutations (3 papers), HER2/EGFR in Cancer Research (3 papers), Synthesis of heterocyclic compounds (2 papers), Catalytic Cross-Coupling Reactions (2 papers), PI3K/AKT/mTOR signaling in cancer (2 papers) and Estrogen and related hormone effects (2 papers). The work is most often cited by research in Computational Theory and Mathematics (150 citations), Cancer Research (122 citations), Organic Chemistry (265 citations), Genetics (188 citations) and Molecular Biology (244 citations). Stuart E. Pearson has collaborated with scholars based in United Kingdom, Sweden and China. Frequent co-authors include James S. Scott, Santosh Nandan, Ryan D. R. Greenwood, F. Geoffrey N. Cloke, Stephen Caddick, Kevin Hudson, Richard A. Norman, Alessandro T. Caputo, Jonathan M. Wingfield and Martin Vogtherr. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Bioorganic & Medicinal Chemistry, Synthesis and MedChemComm.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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