Roger A. Smith

3.7k citations

60 papers · 2.8k · 1 hit paper · h-index 22

Impact in

Organic Chemistry top 2%
- Synthesis and biological activity
- Click Chemistry and Applications
Hepatology top 5%
- Hepatocellular Carcinoma Treatment and Prognosis

Papers in

Organic Chemistry 29
- Synthesis and biological activity 7
- Cyclopropane Reaction Mechanisms 5
- Organic Chemistry Cycloaddition Reactions 5
Molecular Biology 23
- Melanoma and MAPK Pathways 11

Co-authors: Jacques Dumas (7 shared papers)Timothy B. Lowinger (7 shared papers)Scott M. Wilhelm (4 shared papers)Brian Schwartz (2 shared papers)Ronit Simantov (2 shared papers)Christopher Carter (2 shared papers)Susan L. Kelley (2 shared papers)Mark Lynch (2 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (10 papers)The Journal of Organic Chemistry (6 papers)Journal of the American Chemical Society (6 papers)Molecular Cancer Therapeutics (5 papers)Cancer Research (4 papers)
Partner nations: United States Canada Germany

In The Last Decade

Roger A. Smith

60 papers receiving 2.7k citations

Roger A. Smith's Hit Papers

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Discovery and development of sorafenib: a multikinase inhibitor for treating cancer 2006 · 1.5k citations

Peers

Countries citing papers authored by Roger A. Smith

Since Specialization

Citations

This map shows the geographic impact of Roger A. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Roger A. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Roger A. Smith more than expected).

Fields of papers citing papers by Roger A. Smith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Roger A. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Roger A. Smith. The network helps show where Roger A. Smith may publish in the future.

Co-authors

The 25 scholars most cited alongside Roger A. Smith, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Roger A. Smith Line = papers co-authored together Roger A. Smith links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	Discovery and development of sorafenib: a multikinase inhibitor for treating cancer Nature Reviews Drug Discovery ·Scott M. Wilhelm, Christopher Carter, Mark Lynch, Timothy B. Lowinger, Jacques Dumas, Roger A. Smith, Brian Schwartz, Ronit Simantov, Susan L. Kelley Hit paper breakdown →	2006	1461
2	Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases Biochemistry ·Allen Krantz, Leslie J. Copp, Peter J. Coles, Roger A. Smith, Stephen B. Heard	1991	127
3	Design and Discovery of Small Molecules Targeting Raf-1 Kinase Current Pharmaceutical Design ·Timothy B. Lowinger, Bernd Riedl, Jacques Dumas, Roger A. Smith	2002	119
4	Efficient .alpha.-halogenation of acyl chlorides by N-bromosuccinimide, N-chlorosuccinimide, and molecular iodine The Journal of Organic Chemistry ·David N. Harpp, Bao Li, Catherine J. Black, John G. Gleason, Roger A. Smith	1975	75
5	Organic sulfur chemistry. 42. Sulfur-sulfur bond cleavage processes. Selective desulfurization of trisulfides Journal of the American Chemical Society ·David N. Harpp, Roger A. Smith	1982	71
6	Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach Bioorganic & Medicinal Chemistry Letters ·Roger A. Smith, J A Barbosa, Cheri L. Blum, Mark A. Bobko, Yolanda Caringal, Robert Dally, Jeffrey S. Johnson, Michael Katz, Nancy Kennure, Jill Kingery-Wood, Wendy Lee, Timothy B. Lowinger, John F. Lyons, Vivienne Marsh, Daniel H. Rogers, Stephen G. Swartz, Tracy L. Walling, Hanno Wild	2001	70
7	New inhibitors of cysteine proteinases. Peptidyl acyloxymethyl ketones and the quiescent nucleofuge strategy Journal of the American Chemical Society ·Roger A. Smith, Leslie J. Copp, Peter J. Coles, Henry W. Pauls, Valerie J. Robinson, Robin W. Spencer, Stephen B. Heard, Allen Krantz	1988	53
8	Inhibition of cathepsin B by peptidyl aldehydes and ketones: slow-binding behavior of a trifluoromethyl ketone Biochemistry ·Roger A. Smith, Leslie J. Copp, Sheila L. Donnelly, Robin W. Spencer, Allen Krantz	1988	44
9	Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases Biochemical Journal ·Diana H. Pliura, Bonnie J. Bonaventura, Roger A. Smith, Peter J. Coles, Allen Krantz	1992	42
10	The Synthesis of Thiocyanates from Sulfenyl Chlorides and Trimethylsilyl Cyanide Synthesis ·David N. Harpp, B. T. FRIEDLANDER, Roger A. Smith	1979	42
11	Solid-phase synthesis of a library of piperazinediones and diazepinediones via kaiser oxime resin Bioorganic & Medicinal Chemistry Letters ·Roger A. Smith, Mark A. Bobko, Wendy Lee	1998	39
12	Recent Advances in the Research and Development of RAF Kinase Inhibitors Current Topics in Medicinal Chemistry ·Roger A. Smith, Jacques Dumas, Lila Adnane, Scott M. Wilhelm	2006	37
13	Discovery of a new class of p38 kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Jacques Dumas, Robert Sibley, Bernd Riedl, Mary Katherine Monahan, Wendy Lee, Timothy B. Lowinger, Anikó M. Redman, Jeffrey S. Johnson, Jill Kingery-Wood, William J. Scott, Roger A. Smith, Mark A. Bobko, Robert Schoenleber, Gerald Ranges, Timothy J Housley, Ajay Bhargava, Scott M. Wilhelm, Alka Shrikhande	2000	34
14	Infra-red study of carbon-oxygen surface complexes Transactions of the Faraday Society ·R. Nelson Smith, D. A. Young, Roger A. Smith	1966	34
15	Peptidyl O-acyl hydroxamates: Potent new inactivators of cathepsin B Biochemical and Biophysical Research Communications ·Roger A. Smith, Peter J. Coles, Robin W. Spencer, Leslie J. Copp, Christopher S. Jones, Allen Krantz	1988	33
16	Recent developments in the discovery of protein kinase inhibitors from the urea class. PubMed ·Jacques Dumas, Roger A. Smith, Timothy B. Lowinger	2004	31
17	In vivo Inhibition of Cathepsin B by Peptidyl (Acyloxy)methyl Ketones Journal of Medicinal Chemistry ·Bonnie M. Wagner, Roger A. Smith, Peter J. Coles, Leslie J. Copp, Michael J. Ernest, Allen Krantz	1994	27
18	Stereoisomers of allenic amines as inactivators of monoamine oxidase type B. Stereochemical probes of the active site Journal of Medicinal Chemistry ·Roger A. Smith, Robert L. White, Allen Krantz	1988	26
19	Nature of papain products resulting from inactivation by a peptidyl O‐acyl hydroxamate FEBS Letters ·Robert Ménard, Rong Feng, Andrew C. Storer, Valerie J. Robinson, Roger A. Smith, Allen Krantz	1991	23
20	Organic sulfur chemistry. 38. Desulfurization of organic trisulfides by tris(dialkylamino)phosphines. Mechanistic aspects The Journal of Organic Chemistry ·David N. Harpp, D. K. ASH, Roger A. Smith	1980	23

About Roger A. Smith

Roger A. Smith is a scholar working on Organic Chemistry, Molecular Biology, Oncology, Cancer Research and Computational Theory and Mathematics, having authored 60 papers that have together received 2.8k indexed citations. Recurring topics across this work include Melanoma and MAPK Pathways (11 papers), Protease and Inhibitor Mechanisms (9 papers), Peptidase Inhibition and Analysis (8 papers), Computational Drug Discovery Methods (7 papers), Synthesis and biological activity (7 papers), Monoclonal and Polyclonal Antibodies Research (6 papers), Cyclopropane Reaction Mechanisms (5 papers) and Organic Chemistry Cycloaddition Reactions (5 papers). The work is most often cited by research in Organic Chemistry (878 citations), Hepatology (212 citations), Oncology (632 citations), Cancer Research (348 citations) and Molecular Biology (1.3k citations). Roger A. Smith has collaborated with scholars based in United States, Canada and Germany. Frequent co-authors include Jacques Dumas, Timothy B. Lowinger, Scott M. Wilhelm, Brian Schwartz, Ronit Simantov, Christopher Carter, Susan L. Kelley, Mark Lynch, David N. Harpp and Allen Krantz. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, The Journal of Organic Chemistry, Journal of the American Chemical Society, Molecular Cancer Therapeutics and Cancer Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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