Roger A. Smith

3.7k citations

51 papers · 2.9k · 1 hit paper · h-index 23

Impact in

Organic Chemistry top 2%
- Synthesis and biological activity
- Click Chemistry and Applications
Hepatology top 5%
- Hepatocellular Carcinoma Treatment and Prognosis

Papers in

Organic Chemistry 24
- Cyclopropane Reaction Mechanisms 5
- Organic Chemistry Cycloaddition Reactions 5
- Sulfur-Based Synthesis Techniques 5
- Chemical Synthesis and Reactions 4
Cancer Research 10
- Protease and Inhibitor Mechanisms 9

Co-authors: Jacques Dumas (6 shared papers)Timothy B. Lowinger (5 shared papers)Scott M. Wilhelm (3 shared papers)Susan L. Kelley (1 shared paper)Ronit Simantov (1 shared paper)Christopher J. Carter (1 shared paper)Mark John Lynch (1 shared paper)Brian E. Schwartz (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (10 papers)The Journal of Organic Chemistry (6 papers)Journal of the American Chemical Society (6 papers)Tetrahedron Letters (2 papers)Journal of Medicinal Chemistry (2 papers)
Partner nations: United States Canada Germany

In The Last Decade

Roger A. Smith

49 papers receiving 2.7k citations

Roger A. Smith's Hit Papers

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Discovery and development of sorafenib: a multikinase inhibitor for treating cancer 2006 · 1.5k citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2006 Nature Reviews Drug Discovery

Peers

Countries citing papers authored by Roger A. Smith

Since Specialization

Citations

This map shows the geographic impact of Roger A. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Roger A. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Roger A. Smith more than expected).

Fields of papers citing papers by Roger A. Smith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Roger A. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Roger A. Smith. The network helps show where Roger A. Smith may publish in the future.

Co-authors

The 25 scholars most cited alongside Roger A. Smith, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Roger A. Smith Line = papers co-authored together Roger A. Smith links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 51 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Discovery and development of sorafenib: a multikinase inhibitor for treating cancer Nature Reviews Drug Discovery ·Scott M. Wilhelm, Christopher J. Carter, Mark John Lynch, Timothy B. Lowinger, Jacques Dumas, Roger A. Smith, Brian E. Schwartz, Ronit Simantov, Susan L. Kelley Hit paper breakdown →	2006	1523
2	Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases Biochemistry ·Allen Krantz, Leslie J. Copp, Peter J. Coles, Roger A. Smith, Stephen B. Heard	1991	131
3	Design and Discovery of Small Molecules Targeting Raf-1 Kinase Current Pharmaceutical Design ·Timothy B. Lowinger, Bernd Riedl, Jacques Dumas, Roger A. Smith	2002	127
4	Efficient .alpha.-halogenation of acyl chlorides by N-bromosuccinimide, N-chlorosuccinimide, and molecular iodine The Journal of Organic Chemistry ·David N. Harpp, Bao Qiang Li, Catherine J. Black, John G. Gleason, Roger A. Smith	1975	78
5	Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach Bioorganic & Medicinal Chemistry Letters ·Roger A. Smith, James A. Barbosa, Cheri L. Blum, Mark A. Bobko, Yolanda Caringal, Robert D. Dally, Jeffrey S. Johnson, Michael Katz, Nancy Kennure, Jill E. Kingery-Wood, Wendy W.L. Lee, Timothy B. Lowinger, John F. Lyons, Vivienne Marsh, Daniel H. Rogers, Stephen G. Swartz, Tracy L. Walling, Hanno Wild	2001	76
6	Organic sulfur chemistry. 42. Sulfur-sulfur bond cleavage processes. Selective desulfurization of trisulfides Journal of the American Chemical Society ·David N. Harpp, Roger A. Smith	1982	73
7	New inhibitors of cysteine proteinases. Peptidyl acyloxymethyl ketones and the quiescent nucleofuge strategy Journal of the American Chemical Society ·Roger A. Smith, Leslie J. Copp, Peter J. Coles, Henry W. Pauls, Valerie J. Robinson, Robin W. Spencer, Stephen B. Heard, Allen Krantz	1988	55
8	Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases Biochemical Journal ·Diana H. Pliura, Bonnie J. Bonaventura, Roger A. Smith, Peter J. Coles, Allen Krantz	1992	46
9	The Synthesis of Thiocyanates from Sulfenyl Chlorides and Trimethylsilyl Cyanide Synthesis ·David N. Harpp, Barry T. Friedlander, Roger A. Smith	1979	46
10	Solid-phase synthesis of a library of piperazinediones and diazepinediones via kaiser oxime resin Bioorganic & Medicinal Chemistry Letters ·Roger A. Smith, Mark A. Bobko, Wendy W.L. Lee	1998	44
11	Inhibition of cathepsin B by peptidyl aldehydes and ketones: slow-binding behavior of a trifluoromethyl ketone Biochemistry ·Roger A. Smith, Leslie J. Copp, Sheila L. Donnelly, Robin W. Spencer, Allen Krantz	1988	43
12	Recent Advances in the Research and Development of RAF Kinase Inhibitors Current Topics in Medicinal Chemistry ·Roger A. Smith, Jacques Dumas, Lila Adnane, Scott M. Wilhelm	2006	39
13	Infra-red study of carbon-oxygen surface complexes Transactions of the Faraday Society ·R. Nelson Smith, David A. Young, Roger A. Smith	1966	36
14	Discovery of a new class of p38 kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Jacques Dumas, Robert Sibley, Bernd Riedl, Mary Katherine Monahan, Wendy W.L. Lee, Timothy B. Lowinger, Anikó M. Redman, Jeffrey S. Johnson, Jill E. Kingery-Wood, William J. Scott, Roger A. Smith, Mark A. Bobko, Robert W. Schoenleber, Gerald E. Ranges, Timothy J Housley, Ajay Bhargava, Scott M. Wilhelm, Alka Shrikhande	2000	36
15	Peptidyl O-acyl hydroxamates: Potent new inactivators of cathepsin B Biochemical and Biophysical Research Communications ·Roger A. Smith, Peter J. Coles, Robin W. Spencer, Leslie J. Copp, Christopher S. Jones, Allen Krantz	1988	32
16	Recent developments in the discovery of protein kinase inhibitors from the urea class. PubMed ·Jacques Dumas, Roger A. Smith, Timothy B. Lowinger	2004	31
17	Stereoisomers of allenic amines as inactivators of monoamine oxidase type B. Stereochemical probes of the active site Journal of Medicinal Chemistry ·Roger A. Smith, Robert L. White, Allen Krantz	1988	27
18	In vivo Inhibition of Cathepsin B by Peptidyl (Acyloxy)methyl Ketones Journal of Medicinal Chemistry ·Bonnie M. Wagner, Roger A. Smith, Peter J. Coles, Leslie J. Copp, Michael J. Ernest, Allen Krantz	1994	27
19	Organic sulfur chemistry. 38. Desulfurization of organic trisulfides by tris(dialkylamino)phosphines. Mechanistic aspects The Journal of Organic Chemistry ·David N. Harpp, David K. Ash, Roger A. Smith	1980	24
20	Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives Bioorganic & Medicinal Chemistry Letters ·Roger A. Smith, Zahra Fathi, Su-Ellen Brown, Soongyu Choi, Jianmei Fan, Susan Jenkins, Harold C.E. Kluender, Anish A. Konkar, Rico Lavoie, Ronald Mays, Jennifer Natoli, Stephen J. M. O'Connor, Astrid A. Ortiz, Brent L. Podlogar, Christy Taing, Susan A. Tomlinson, Theresa Tritto, Zhonghua Zhang	2006	24

About Roger A. Smith

Roger A. Smith is a scholar working on Organic Chemistry, Cancer Research, Physical and Theoretical Chemistry, Oncology and Molecular Biology, having authored 51 papers that have together received 2.9k indexed citations. Recurring topics across this work include Protease and Inhibitor Mechanisms (9 papers), Peptidase Inhibition and Analysis (8 papers), Cyclopropane Reaction Mechanisms (5 papers), Organic Chemistry Cycloaddition Reactions (5 papers), Chemical Reactions and Mechanisms (5 papers), Sulfur-Based Synthesis Techniques (5 papers), Melanoma and MAPK Pathways (5 papers) and Chemical Synthesis and Reactions (4 papers). The work is most often cited by research in Organic Chemistry (922 citations), Hepatology (220 citations), Cancer Research (365 citations), Oncology (657 citations) and Molecular Biology (1.3k citations). Roger A. Smith has collaborated with scholars based in United States, Canada and Germany. Frequent co-authors include Jacques Dumas, Timothy B. Lowinger, Scott M. Wilhelm, Susan L. Kelley, Ronit Simantov, Christopher J. Carter, Mark John Lynch, Brian E. Schwartz, David N. Harpp and Allen Krantz. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, The Journal of Organic Chemistry, Journal of the American Chemical Society, Tetrahedron Letters and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Roger A. Smith's Hit Papers

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