Mark Searcey

2.4k citations

85 papers · 2.0k · h-index 27

Impact in

Toxicology top 1%
Organic Chemistry top 2%
- Click Chemistry and Applications
- Synthesis and Biological Evaluation

Papers in

Molecular Biology 60
- Chemical Synthesis and Analysis 21
- DNA and Nucleic Acid Chemistry 21
- Cancer therapeutics and mechanisms 20
- Advanced biosensing and bioanalysis techniques 9
Organic Chemistry 39
- Click Chemistry and Applications 12
- Synthesis and Biological Evaluation 12
- Carbohydrate Chemistry and Synthesis 7

Co-authors: Maria A. O’Connell (16 shared papers)Dale L. Boger (13 shared papers)David A. Russell (4 shared papers)María J. Marín (3 shared papers)Lesley A. Howell (12 shared papers)Klaus Pors (12 shared papers)John P. Malkinson (5 shared papers)Qing Jin (6 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (7 papers)Tetrahedron Letters (6 papers)The Journal of Organic Chemistry (5 papers)Chemical Communications (4 papers)Journal of Medicinal Chemistry (3 papers)
Partner nations: United Kingdom United States Ireland

In The Last Decade

Mark Searcey

84 papers receiving 2.0k citations

Peers

Countries citing papers authored by Mark Searcey

Since Specialization

Citations

This map shows the geographic impact of Mark Searcey's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mark Searcey with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mark Searcey more than expected).

Fields of papers citing papers by Mark Searcey

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mark Searcey. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mark Searcey. The network helps show where Mark Searcey may publish in the future.

Co-authors

The 25 scholars most cited alongside Mark Searcey, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Mark Searcey Line = papers co-authored together Mark Searcey links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 85 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Active targeting of gold nanoparticles as cancer therapeutics Chemical Society Reviews ·Zoë Goddard, María J. Marín, David A. Russell, Mark Searcey	2020	237
2	Design, Synthesis, and Evaluation of an α-Helix Mimetic Library Targeting Protein−Protein Interactions Journal of the American Chemical Society ·Alex Shaginian, Landon R. Whitby, Sukwon Hong, Inkyu Hwang, Bilal Farooqi, Mark Searcey, Jiandong Chen, Peter K. Vogt, Dale L. Boger	2009	127
3	Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction ACS Medicinal Chemistry Letters ·Richard Steel, Jonathan Cowan, Estelle Payerne, Maria A. O’Connell, Mark Searcey	2012	97
4	Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies Natural Product Reports ·Simon J. Dawson, John P. Malkinson, David Paumier, Mark Searcey	2006	90
5	Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties Inorganic Chemistry ·Benoı̂t Bertrand, Julio Fernández‐Cestau, Jesús Angulo, Marco M. D. Cominetti, Zoë A. E. Waller, Mark Searcey, Maria A. O’Connell, Manfred Bochmann	2017	63
6	Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked‐X Four‐Way Junction by a Small Molecule Angewandte Chemie International Edition ·Anna L. Brogden, Nicholas H. Hopcroft, Mark Searcey, Christine J. Cardin	2007	53
7	Chemical and Biological Explorations of the Family of CC-1065 and the Duocarmycin Natural Products Current Topics in Medicinal Chemistry ·Nandita Ghosh, Helen M. Sheldrake, Mark Searcey, Klaus Pors	2009	49
8	Synthesis of DNA-Directed Pyrrolidinyl and Piperidinyl Confined Alkylating Chloroalkylaminoanthraquinones: Potential for Development of Tumor-Selective N-Oxides Journal of Medicinal Chemistry ·Klaus Pors, Steven D. Shnyder, Paul Teesdale‐Spittle, John A. Hartley, Mire Zloh, Mark Searcey, Laurence H. Patterson	2006	45
9	Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies Metallomics ·Morwen Williams, Benoı̂t Bertrand, David L. Hughes, Zoë A. E. Waller, Claudia Schmidt, Ingo Ott, Maria A. O’Connell, Mark Searcey, Manfred Bochmann	2018	44
10	Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride Tetrahedron Letters ·Dale L. Boger, Christopher W. Boyce, R. M. Garbaccio, Mark Searcey	1998	44
11	X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)2 molecules by a bis(9-aminoacridine-4-carboxamide) derivative Nucleic Acids Research ·Nicholas H. Hopcroft, Anna L. Brogden, Mark Searcey, Christine J. Cardin	2006	43
12	Total Synthesis and Comparative Evaluation of Luzopeptin A−C and Quinoxapeptin A−C Journal of the American Chemical Society ·Dale L. Boger, Mark W. Ledeboer, Masaharu Kume, Mark Searcey, Qing Jin	1999	43
13	Critical Role of the Linking Amide in CC-1065 and the Duocarmycins: Implications on the Source of DNA Alkylation Catalysis Journal of the American Chemical Society ·Dale L. Boger, Alejandro Santillán, Mark Searcey, Qing Jin	1998	41
14	The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction Natural Product Reports ·Ryan C. Clark, Sang Yeul Lee, Mark Searcey, Dale L. Boger	2009	38
15	Synthesis of distamycin A polyamides targeting G-quadruplex DNA Organic & Biomolecular Chemistry ·Michael J. Moore, Francisco Cuenca, Mark Searcey, Stephen Neidle	2006	38
16	Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Molecular Cancer Therapeutics ·Mark Sutherland, Jason H. Gill, Paul M. Loadman, Jonathan P. Laye, Helen M. Sheldrake, Nicola A. Illingworth, Mohammed N. Alandas, Patricia A. Cooper, Mark Searcey, Klaus Pors, Steven D. Shnyder, Laurence H. Patterson	2012	36
17	A polyclonal antibody preparation with Michaelian catalytic properties Biochemical Journal ·Gerard Gallacher, Caroline S. Jackson, Mark Searcey, G. Badman, Rajeev Goel, Christopher M. Topham, Geoffrey W. Mellor, K Brocklehurst	1991	36
18	Solid-Phase Synthesis of the Cyclic Peptide Portion of Chlorofusin, an Inhibitor of p53-MDM2 Interactions Organic Letters ·John P. Malkinson, Mire Zloh, Mohanad Kadom, Rachel J. Errington, Paul J. Smith, Mark Searcey	2003	32
19	Duocarmycins - Natures Prodrugs? Current Pharmaceutical Design ·Mark Searcey	2002	32
20	A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators Tetrahedron Letters ·Petros G. Tsoungas, Mark Searcey	2001	32

About Mark Searcey

Mark Searcey is a scholar working on Molecular Biology, Organic Chemistry, Oncology, Pharmacology and Pharmacology, having authored 85 papers that have together received 2.0k indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (21 papers), DNA and Nucleic Acid Chemistry (21 papers), Cancer therapeutics and mechanisms (20 papers), Click Chemistry and Applications (12 papers), Synthesis and Biological Evaluation (12 papers), Advanced biosensing and bioanalysis techniques (9 papers), Microbial Natural Products and Biosynthesis (8 papers) and Carbohydrate Chemistry and Synthesis (7 papers). The work is most often cited by research in Toxicology (122 citations), Organic Chemistry (880 citations), Molecular Biology (1.3k citations), Oncology (336 citations) and Pharmacology (197 citations). Mark Searcey has collaborated with scholars based in United Kingdom, United States and Ireland. Frequent co-authors include Maria A. O’Connell, Dale L. Boger, David A. Russell, María J. Marín, Lesley A. Howell, Klaus Pors, John P. Malkinson, Qing Jin, Laurence H. Patterson and Christine J. Cardin. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, The Journal of Organic Chemistry, Chemical Communications and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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