Luc Roumen

941 citations

21 papers · 736 · h-index 16

Impact in

Computational Theory and Mathematics top 5%
- Computational Drug Discovery Methods
Oncology top 10%
- Chemokine receptors and signaling

Papers in

Molecular Biology 16
- Receptor Mechanisms and Signaling 10
- Chemical Synthesis and Analysis 6
- Steroid Chemistry and Biochemistry 2
Radiology, Nuclear Medicine and Imaging 10
- Monoclonal and Polyclonal Antibodies Research 10

Co-authors: Chris de Graaf (15 shared papers)Rob Leurs (14 shared papers)Iwan J. P. de Esch (12 shared papers)Danny J. Scholten (4 shared papers)Martine J. Smit (5 shared papers)Maikel Wijtmans (5 shared papers)Meritxell Canals (3 shared papers)Marijn P. A. Sanders (5 shared papers)
Journals: Journal of Medicinal Chemistry (4 papers)Molecular Pharmacology (2 papers)MedChemComm (2 papers)European Journal of Medicinal Chemistry (1 paper)Journal of the American Chemical Society (1 paper)
Partner nations: Netherlands China Germany

In The Last Decade

Luc Roumen

21 papers receiving 709 citations

Peers

Countries citing papers authored by Luc Roumen

Since Specialization

Citations

This map shows the geographic impact of Luc Roumen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Luc Roumen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Luc Roumen more than expected).

Fields of papers citing papers by Luc Roumen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Luc Roumen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Luc Roumen. The network helps show where Luc Roumen may publish in the future.

Co-authors

The 25 scholars most cited alongside Luc Roumen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Luc Roumen Line = papers co-authored together Luc Roumen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 21 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Pharmacological modulation of chemokine receptor function British Journal of Pharmacology ·Danny J. Scholten, Meritxell Canals, David Maussang, Luc Roumen, Martine J. Smit, Maikel Wijtmans, Chris de Graaf, HF Vischer, Rob Leurs	2011	200
2	From the protein's perspective: the benefits and challenges of protein structure-based pharmacophore modeling MedChemComm ·Marijn P. A. Sanders, Ross McGuire, Luc Roumen, Iwan J. P. de Esch, Jacob de Vlieg, Jan P.G. Klomp, Chris de Graaf	2011	76
3	Switching from S- to R-Selectivity in the Candida antarctica Lipase B-Catalyzed Ring-Opening of ω-Methylated Lactones: Tuning Polymerizations by Ring Size Journal of the American Chemical Society ·Jeroen van Buijtenen, Bart A. C. van As, M. A. L. Verbruggen, Luc Roumen, Jef A. J. M. Vekemans, K. Pieterse, P.A.J. Hilbers, Lumbertus A. Hulshof, Anja R. A. Palmans, E. W. Meijer	2007	52
4	Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics Journal of Computer-Aided Molecular Design ·Luc Roumen, Marijn P. A. Sanders, K. Pieterse, P.A.J. Hilbers, Ralf Plate, Erica M.G. Custers, Marcel de Gooyer, Jos F.M. Smits, Ilona P. E. Beugels, Judith M. A. Emmen, H. C. J. OTTENHEIJM, Dirk Leysen, J. J. Rob Hermans	2007	47
5	Molecular Determinants of Ligand Binding Modes in the Histamine H₄Receptor: Linking Ligand-Based Three-Dimensional Quantitative Structure–Activity Relationship (3D-QSAR) Models to in Silico Guided Receptor Mutagenesis Studies Journal of Medicinal Chemistry ·Enade Perdana Istyastono, Saskia Nijmeijer, Herman D. Lim, Andrea van de Stolpe, Luc Roumen, Albert J. Kooistra, Henry F. Vischer, Iwan J. P. de Esch, Rob Leurs, Chris de Graaf	2011	46
6	From Heptahelical Bundle to Hits from the Haystack Methods in enzymology on CD-ROM/Methods in enzymology ·Albert J. Kooistra, Luc Roumen, Rob Leurs, Iwan J. P. de Esch, Chris de Graaf	2013	43
7	Snooker: A Structure-Based Pharmacophore Generation Tool Applied to Class A GPCRs Journal of Chemical Information and Modeling ·Marijn P. A. Sanders, Stefan Verhoeven, Chris de Graaf, Luc Roumen, Bas Vroling, Sander B. Nabuurs, Jacob de Vlieg, Jan P.G. Klomp	2011	42
8	Synthesis, Biological Evaluation, and Molecular Modeling of 1-Benzyl-1H-imidazoles as Selective Inhibitors of Aldosterone Synthase (CYP11B2) Journal of Medicinal Chemistry ·Luc Roumen, Joris W. Peeters, Judith M. A. Emmen, Ilona P. E. Beugels, Erica M.G. Custers, Marcel de Gooyer, Ralf Plate, K. Pieterse, P.A.J. Hilbers, Jos F.M. Smits, Jef A. J. M. Vekemans, Dirk Leysen, H. C. J. OTTENHEIJM, Henk M. Janssen, J. J. Rob Hermans	2010	34
9	A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design Journal of Medicinal Chemistry ·Marijn P. A. Sanders, Luc Roumen, Eelke van der Horst, J. Robert Lane, Henry F. Vischer, Jody van Offenbeek, Henk de Vries, Stefan Verhoeven, Ken Y.C. Chow, Folkert Verkaar, Margot W. Beukers, Ross McGuire, Rob Leurs, Adriaan P. IJzerman, Jacob de Vlieg, Iwan J. P. de Esch, Guido J.R. Zaman, Jan P.G. Klomp, Andreas Bender, Chris de Graaf	2012	26
10	Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H₄receptor MedChemComm ·Enade Perdana Istyastono, Albert J. Kooistra, Henry F. Vischer, Martien Kuijer, Luc Roumen, Saskia Nijmeijer, Rogier A. Smits, Iwan J. P. de Esch, Rob Leurs, Chris de Graaf	2015	26
11	Identification of a Novel Allosteric Binding Site in the CXCR2 Chemokine Receptor Molecular Pharmacology ·Petra de Kruijf, Herman D. Lim, Luc Roumen, Véronique A. Renjaän, Jiuqiao Zhao, Maria L. Webb, Douglas S. Auld, Jac C.H.M. Wijkmans, Guido J.R. Zaman, Martine J. Smit, Chris de Graaf, Rob Leurs	2011	23
12	Chemical Subtleties in Small-Molecule Modulation of Peptide Receptor Function: The Case of CXCR3 Biaryl-Type Ligands Journal of Medicinal Chemistry ·Maikel Wijtmans, Danny J. Scholten, Luc Roumen, Meritxell Canals, Hans Custers, Marjolein Glas, Marlies C. A. Vreeker, Frans J. J. de Kanter, Chris de Graaf, Martine J. Smit, Iwan J. P. de Esch, Rob Leurs	2012	22
13	Identification of Overlapping but Differential Binding Sites for the High-Affinity CXCR3 Antagonists NBI-74330 and VUF11211 Molecular Pharmacology ·Danny J. Scholten, Luc Roumen, Maikel Wijtmans, Marlies C. A. Verkade‐Vreeker, Hans Custers, Michael M. C. Lai, Daniela de Hooge, Meritxell Canals, Iwan J. P. de Esch, Martine J. Smit, Chris de Graaf, Rob Leurs	2013	20
14	Fadrozole Reverses Cardiac Fibrosis in Spontaneously Hypertensive Heart Failure Rats: Discordant Enantioselectivity Versus Reduction of Plasma Aldosterone Endocrinology ·Monica Minnaard‐Huiban, Judith M. A. Emmen, Luc Roumen, Ilona P. E. Beugels, Géraldine Cohuet, Helma van Essen, Eveline Ruijters, K. Pieterse, P.A.J. Hilbers, H. C. J. OTTENHEIJM, Ralf Plate, Marcel E. de Gooyer, Jos F.M. Smits, J. J. Rob Hermans	2007	19
15	C(X)CR in silico: Computer-aided prediction of chemokine receptor–ligand interactions Drug Discovery Today Technologies ·Luc Roumen, Danny J. Scholten, Petra de Kruijf, Iwan J. P. de Esch, Rob Leurs, Chris de Graaf	2012	18
16	In Silico Veritas: The Pitfalls and Challenges of Predicting GPCR-Ligand Interactions Pharmaceuticals ·Luc Roumen, Marijn P. A. Sanders, Bas Vroling, Iwan J. P. de Esch, Jacob de Vlieg, Rob Leurs, Jan P.G. Klomp, Sander B. Nabuurs, Chris de Graaf	2011	16
17	Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists European Journal of Medicinal Chemistry ·Ilze Adlere, Shan‐Liang Sun, Aurélien Zarca, Luc Roumen, Mahmut Gozelle, Cristina Perpiñá-Viciano, Birgit Caspar, Marta Arimont, Jan Paul Bebelman, Stephen J. Briddon, Carsten Hoffmann, Stephen J. Hill, Martine J. Smit, Henry F. Vischer, Maikel Wijtmans, Chris de Graaf, Iwan J. P. de Esch, Rob Leurs	2018	11
18	Combining Quantum Mechanical Ligand Conformation Analysis and Protein Modeling to Elucidate GPCR–Ligand Binding Modes ChemMedChem ·Sabine Schultes, Harald Engelhardt, Luc Roumen, Obbe P. Zuiderveld, Eric Haaksma, Iwan J. P. de Esch, Rob Leurs, Chris de Graaf	2012	6
19	Regiochemistry of the Condensation of 2-Aroyl-cyclohexanones and 2-Cyanoacetamide: ¹³C-Labeling Studies and Semiempirical MO Calculations The Journal of Organic Chemistry ·Oscar P. J. van Linden, Maikel Wijtmans, Luc Roumen, Lonneke Rotteveel, Rob Leurs, Iwan J. P. de Esch	2012	6
20	Application of a ligand‐based theoretical approach to derive conversion paths and ligand conformations in CYP11B2‐mediated aldosterone formation Journal of Computational Chemistry ·Luc Roumen, Bram van Hoof, K. Pieterse, P.A.J. Hilbers, Erica M.G. Custers, Ralf Plate, Marcel de Gooyer, Ilona P. E. Beugels, Judith M. A. Emmen, Dirk Leysen, Jos F.M. Smits, H. C. J. OTTENHEIJM, J. J. Rob Hermans	2011	2

About Luc Roumen

Luc Roumen is a scholar working on Molecular Biology, Radiology, Nuclear Medicine and Imaging, Oncology, Computational Theory and Mathematics and Endocrinology, Diabetes and Metabolism, having authored 21 papers that have together received 736 indexed citations. Recurring topics across this work include Monoclonal and Polyclonal Antibodies Research (10 papers), Receptor Mechanisms and Signaling (10 papers), Computational Drug Discovery Methods (6 papers), Chemical Synthesis and Analysis (6 papers), Chemokine receptors and signaling (6 papers), Hormonal Regulation and Hypertension (4 papers), Steroid Chemistry and Biochemistry (2 papers) and Neuropeptides and Animal Physiology (2 papers). The work is most often cited by research in Computational Theory and Mathematics (185 citations), Oncology (239 citations), Immunology (165 citations), Radiology, Nuclear Medicine and Imaging (167 citations) and Pharmacology (59 citations). Luc Roumen has collaborated with scholars based in Netherlands, China and Germany. Frequent co-authors include Chris de Graaf, Rob Leurs, Iwan J. P. de Esch, Danny J. Scholten, Martine J. Smit, Maikel Wijtmans, Meritxell Canals, Marijn P. A. Sanders, David Maussang and Jacob de Vlieg. Their work appears in journals such as Journal of Medicinal Chemistry, Molecular Pharmacology, MedChemComm, European Journal of Medicinal Chemistry and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Luc Roumen

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