Leon M. Smith

1.8k citations

17 papers · 1.5k · 1 hit paper · h-index 14

Impact in

Molecular Biology top 10%
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
Organic Chemistry top 10%
- Synthesis and biological activity
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Characterization of Heterocyclic Compounds

Papers in

Organic Chemistry 7
- Synthesis and biological activity 6
- Synthesis of heterocyclic compounds 1
Genetics 3
- Coagulation, Bradykinin, Polyphosphates, and Angioedema 3

Co-authors: John C. Lindon (3 shared papers)Jeremy Kirk Nicholson (3 shared papers)Elaine C. Holmes (3 shared papers)Wai C. Wong (6 shared papers)Alexander S. Kiselyov (5 shared papers)Matthew A. J. Duncton (5 shared papers)Paul Elliott (2 shared papers)Jeremiah Stamler (2 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)Analytical Chemistry (2 papers)The Journal of Organic Chemistry (1 paper)Journal of Proteome Research (1 paper)Journal of Medicinal Chemistry (1 paper)
Partner nations: United States United Kingdom China

In The Last Decade

Leon M. Smith

17 papers receiving 1.5k citations

Leon M. Smith's Hit Papers

align trajectories log scale

Symbiotic gut microbes modulate human metabolic phenotypes 2008 · 946 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2008 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Leon M. Smith

Since Specialization

Citations

This map shows the geographic impact of Leon M. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leon M. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leon M. Smith more than expected).

Fields of papers citing papers by Leon M. Smith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leon M. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leon M. Smith. The network helps show where Leon M. Smith may publish in the future.

Co-authors

The 25 scholars most cited alongside Leon M. Smith, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Leon M. Smith Line = papers co-authored together Leon M. Smith links everyone, so they are left out of the graph.

All Works

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17 of 17 papers shown

#	Work
1	Symbiotic gut microbes modulate human metabolic phenotypes Proceedings of the National Academy of Sciences ·Min Li, Baohong Wang, Menghui H. Zhang, Mattias Rantalainen, Shengyue Wang, Haokui Zhou, Yan Zhang, Jian Shen Hit paper breakdown →	2008	946
2	Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines Bioorganic & Medicinal Chemistry Letters ·Xiaohu Ouyang, Evgueni L. Piatnitski, Vatee Pattaropong, Xiaoling Chen, Haiying He, Alexander S. Kiselyov, Avdhoot D. Velankar, Joel K. Kawakami	2006	95
3	Statistical Correlation and Projection Methods for Improved Information Recovery from Diffusion-Edited NMR Spectra of Biological Samples Analytical Chemistry ·Leon M. Smith, Anthony D. Maher, Olivier Cloarec, Mattias Rantalainen, Huiru Tang, Paul Elliott, Jeremiah Stamler, John C. Lindon	2007	73
4	NMR-Based Metabolic Profiling Identifies Biomarkers of Liver Regeneration Following Partial Hepatectomy in the Rat Journal of Proteome Research ·Mary E. Bollard, Nancy R. Contel, Timothy M. D. Ebbels, Leon M. Smith, Olaf P. Beckonert, Glenn H. Cantor, Lois D. Lehman‐McKeeman, Elaine C. Holmes	2009	73
5	Synthesis and structure–activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors Bioorganic & Medicinal Chemistry Letters ·Xiaohu Ouyang, Xiaoling Chen, Evgueni L. Piatnitski, Alexander S. Kiselyov, Haiying He, Yunyu Mao, Vatee Pattaropong, Yang Yu	2005	67
6	Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212) Journal of Medicinal Chemistry ·Donald J. P. Pinto, Michael J. Orwat, Leon M. Smith, Mimi L. C. Quan, Patrick Y. S. Lam, Karen A. Rossi, Atsu Apedo, Jeffrey M. Bozarth	2017	45
7	Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties Bioorganic & Medicinal Chemistry Letters ·Donald J. P. Pinto, Joanne M. Smallheer, James R. Corte, Erin J.D. Austin, Cailan Wang, Tianan Fang, Leon M. Smith, Karen A. Rossi	2015	36
8	Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2 Bioorganic & Medicinal Chemistry ·Matthew A. J. Duncton, Eugene L. Piatnitski Chekler, Reeti Katoch‐Rouse, Dan Sherman, Wai C. Wong, Leon M. Smith, Joel K. Kawakami, Alexander S. Kiselyov	2008	34
9	Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II Bioorganic & Medicinal Chemistry Letters ·Matthew A. J. Duncton, Evgueni L. Piatnitski, Reeti Katoch‐Rouse, Leon M. Smith, Alexander S. Kiselyov, Daniel L. Milligan, Chris Balagtas, Wai C. Wong	2005	32
10	Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase Bioorganic & Medicinal Chemistry Letters ·Leon M. Smith, Wai C. Wong, Alexander S. Kiselyov, Sabina Burdzovic‐Wizeman, Yunyu Mao, Yong‐Jiang Xu, Matthew A. J. Duncton, Evgueni L. Piatnitski	2006	30
11	Preparation of Substituted Pyrimido[4,5-b]-1,4-benzoxazepines, Thiazepines, and Diazepines via a Pictet−Spengler Cyclization The Journal of Organic Chemistry ·Matthew A. J. Duncton, Leon M. Smith, Sabina Burdzovic‐Wizeman, Aaron C. Burns, Hu Liu, Yunyu Mao, Wai C. Wong, Alexander S. Kiselyov	2005	28
12	Large-Scale Human Metabolic Phenotyping and Molecular Epidemiological Studies via 1H NMR Spectroscopy of Urine: Investigation of Borate Preservation Analytical Chemistry ·Leon M. Smith, Anthony D. Maher, Elizabeth J. Want, Paul Elliott, Jeremiah Stamler, Geoffrey E. Hawkes, Elaine C. Holmes, John C. Lindon	2009	27
13	Novel phenylalanine derived diamides as Factor XIa inhibitors Bioorganic & Medicinal Chemistry Letters ·Leon M. Smith, Michael J. Orwat, Zilun Hu, Cailan Wang, Karen A. Rossi, Paul J. Gilligan, Kumar B. Pabbisetty, Honey Osuna	2015	25
14	Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Leon M. Smith, Evgueni L. Piatnitski, Alexander S. Kiselyov, Xiaohu Ouyang, Xiaoling Chen, Sabina Burdzovic‐Wizeman, Yong‐Jiang Xu, Ying Wang	2006	14
15	Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr Bioorganic & Medicinal Chemistry Letters ·Celia Dominguez, Leon M. Smith, Qi Zhong Huang, Chester Yuan, Xiaohu Ouyang, Paul L. Chen, Joseph Y. Kim, Timothy S. Harvey	2007	13
16	A mild and readily scalable procedure for the N-1-difluoromethylation of ethyl 6-((tert-butyldiphenylsilyl)oxy)-1H-indazole-3-carboxylate and its applications to the N-difluoromethylation of indazole, benzotriazole, imidazole, indole and pyrazole derivatives Journal of Fluorine Chemistry ·Zhenqiu Hong, Xiaoping Hou, Rulin Zhao, Jianqing Li, Joseph M. Pawluczyk, Bei Wang, James Kempson, Purnima Khandelwal	2020	5
17	Efficient Preparation of ((3‐Chloro‐2‐fluoro‐phenyl)‐[7‐methoxy‐8‐(3‐morpholin‐4‐yl‐propoxy)‐10,11‐dihydro‐5‐oxa‐2,4,11‐triaza‐dibenzo(a,d)cyclohepten‐1‐yl]‐amine) for In‐Vivo Study Synthetic Communications ·Hu Liu, Leon M. Smith, Yunyu Mao, Weitao Pan, Yong‐Jiang Xu, Sabina Burdzovic‐Wizeman, Matthew A. J. Duncton, Wai C. Wong	2006	1

About Leon M. Smith

Leon M. Smith is a scholar working on Organic Chemistry, Genetics, Molecular Biology, Hematology and Pharmaceutical Science, having authored 17 papers that have together received 1.5k indexed citations. Recurring topics across this work include Synthesis and biological activity (6 papers), Angiogenesis and VEGF in Cancer (3 papers), Coagulation, Bradykinin, Polyphosphates, and Angioedema (3 papers), Metabolomics and Mass Spectrometry Studies (3 papers), Blood Coagulation and Thrombosis Mechanisms (2 papers), Lung Cancer Treatments and Mutations (1 paper), Synthesis of heterocyclic compounds (1 paper) and Hemophilia Treatment and Research (1 paper). The work is most often cited by research in Molecular Biology (820 citations), Organic Chemistry (287 citations), Genetics (49 citations), Hematology (68 citations) and Pharmacology (34 citations). Leon M. Smith has collaborated with scholars based in United States, United Kingdom and China. Frequent co-authors include John C. Lindon, Jeremy Kirk Nicholson, Elaine C. Holmes, Wai C. Wong, Alexander S. Kiselyov, Matthew A. J. Duncton, Paul Elliott, Jeremiah Stamler, Anthony D. Maher and Jacqueline F. Doody. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Analytical Chemistry, The Journal of Organic Chemistry, Journal of Proteome Research and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Leon M. Smith

Leon M. Smith's Hit Papers

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