Keith Menear

2.9k citations

32 papers · 1.7k · h-index 17

Impact in

Oncology top 5%
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
Molecular Biology top 10%
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- PI3K/AKT/mTOR signaling in cancer
- CRISPR and Genetic Engineering

Papers in

Molecular Biology 24
- Cancer therapeutics and mechanisms 9
- DNA Repair Mechanisms 6
- Chemical Synthesis and Analysis 5
- Receptor Mechanisms and Signaling 2
Oncology 12
- PARP inhibition in cancer therapy 5

Co-authors: Niall M.B. Martin (10 shared papers)Xiaoling Cockcroft (10 shared papers)Graeme C.M. Smith (12 shared papers)Sylvie Gomez (5 shared papers)Marc Hummersone (6 shared papers)Mark J. O’Connor (2 shared papers)Frank Kerrigan (4 shared papers)Mark Frigerio (6 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (14 papers)Journal of Medicinal Chemistry (4 papers)Molecular Cancer Therapeutics (4 papers)Biochemical Pharmacology (1 paper)Cancer Research (1 paper)
Partner nations: United Kingdom Switzerland United States

In The Last Decade

Keith Menear

32 papers receiving 1.6k citations

Peers

Countries citing papers authored by Keith Menear

Since Specialization

Citations

This map shows the geographic impact of Keith Menear's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keith Menear with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keith Menear more than expected).

Fields of papers citing papers by Keith Menear

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keith Menear. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keith Menear. The network helps show where Keith Menear may publish in the future.

Co-authors

The 25 scholars most cited alongside Keith Menear, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Keith Menear Line = papers co-authored together Keith Menear links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 32 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1 Journal of Medicinal Chemistry ·Keith Menear, Claire Adcock, Robert Boulter, Xiaoling Cockcroft, Louise Copsey, Aaron Cranston, Krystyna J. Dillon, Jan Drzewiecki, Sheila Garman, Sylvie Gomez, Hashim Javaid, Frank Kerrigan, Charlotte Knights, Alan Lau, Vincent M. Loh, Ian T.W. Matthews, Stephen Moore, Mark J. O’Connor, Graeme C.M. Smith, Niall M.B. Martin	2008	489
2	Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion Molecular Cancer Therapeutics ·Sarah E. Golding, Elizabeth Rosenberg, Nicholas C.K. Valerie, Isa M. Hussaini, Mark Frigerio, Xiaoling Cockcroft, Wei Yee Chong, Marc Hummersone, Laurent Rigoreau, Keith Menear, Mark J. O’Connor, Lawrence F. Povirk, Timothy Van Meter, Kristoffer Valerie	2009	287
3	Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014 Bioorganic & Medicinal Chemistry Letters ·Kurt G. Pike, Karine Malagu, Marc Hummersone, Keith Menear, Heather M. E. Duggan, Sylvie Gomez, Niall M.B. Martin, Linette Ruston, Sarah L. Pass, Martin Pass	2013	167
4	Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K Molecular Cancer Therapeutics ·Joanne M. Munck, Michael A. Batey, Yan Zhao, Helen Jenkins, Caroline J. Richardson, Céline Cano, Michele Tavecchio, Jody Barbeau, Julia Bárdos, Liam Cornell, Roger J. Griffin, Keith Menear, Andrew Slade, Pia Thömmes, Niall M.B. Martin, David R. Newell, Graeme C.M. Smith, Nicola J. Curtin	2012	100
5	Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase Bioorganic & Medicinal Chemistry Letters ·Vincent M. Loh, Xiaoling Cockcroft, Krystyna J. Dillon, Lesley Dixon, Jan Drzewiecki, Penny J. Eversley, Sylvie Gomez, Janet Hoare, Frank Kerrigan, Ian T.W. Matthews, Keith Menear, Niall M.B. Martin, Roger F. Newton, Jane T. Paul, Graeme C.M. Smith, Julia Vile, Alan J. Whittle	2005	79
6	Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase Bioorganic & Medicinal Chemistry Letters ·Xiaoling Cockcroft, Krystyna J. Dillon, Lesley Dixon, Jan Drzewiecki, Frank Kerrigan, Vincent M. Loh, Niall M.B. Martin, Keith Menear, Graeme C.M. Smith	2005	72
7	Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and Identification of the First Potent and Selective Inhibitor of the Ataxia Telangiectasia Mutated Kinase Journal of Medicinal Chemistry ·Jonathan J. Hollick, Laurent Rigoreau, Céline Cano, Xiaoling Cockcroft, Nicola J. Curtin, Mark Frigerio, Bernard T. Golding, Sophie Guiard, Ian R. Hardcastle, Ian Hickson, Marc Hummersone, Keith Menear, Niall M.B. Martin, Ian Matthews, David R. Newell, Rachel Ord, Caroline J. Richardson, Graeme C.M. Smith, Roger J. Griffin	2007	62
8	Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR Bioorganic & Medicinal Chemistry Letters ·Keith Menear, Sylvie Gomez, Karine Malagu, C. L. Bailey, Kristel Blackburn, Xiaoling Cockcroft, Sally Ewen, Alexandra Fundo, Armelle Le Gall, Gesine Hermann, Luisa Sebastian, Mihiro Sunose, Thomas Presnot, Eleanor Torode, Ian Hickson, Niall M.B. Martin, Graeme C.M. Smith, Kurt G. Pike	2009	51
9	Progress Towards the Discovery of Orally Active Thrombin Inhibitors Current Medicinal Chemistry ·Keith Menear	1998	43
10	1-Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity Journal of Medicinal Chemistry ·Céline Cano, Kappusamy Saravanan, Chris Bailey, Julia Bárdos, Nicola J. Curtin, Mark Frigerio, Bernard T. Golding, Ian R. Hardcastle, Marc Hummersone, Keith Menear, David R. Newell, Caroline J. Richardson, Kerry Shea, Graeme C.M. Smith, Pia Thömmes, Attilla Ting, Roger J. Griffin	2013	42
11	DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype Journal of Medicinal Chemistry ·Céline Cano, Olivier Barbeau, C. L. Bailey, Xiaoling Cockcroft, Nicola J. Curtin, Heather M. E. Duggan, Mark Frigerio, Bernard T. Golding, Ian R. Hardcastle, Marc Hummersone, Charlotte Knights, Keith Menear, David R. Newell, Caroline J. Richardson, Graeme C. M. Smith, Ben Spittle, Roger J. Griffin	2010	35
12	Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase Bioorganic & Medicinal Chemistry Letters ·Keith Menear, Claire Adcock, Francisco Cuenca Alonso, Kristel Blackburn, Louise Copsey, Jan Drzewiecki, Alexandra Fundo, Armelle Le Gall, Sylvie Gomez, Hashim Javaid, Carlos Fenandez Lence, Niall M.B. Martin, Chris Mydlowski, Graeme C.M. Smith	2008	35
13	An intramolecular Diels–Alder approach to forskolin Journal of the Chemical Society Chemical Communications ·Paul R. Jenkins, Keith Menear, Paul Barraclough, M. S. NOBBS	1984	35
14	8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) Bioorganic & Medicinal Chemistry Letters ·Marine Desage‐El Murr, Céline Cano, Bernard T. Golding, Ian R. Hardcastle, Marc Hummersome, Mark Frigerio, Nicola J. Curtin, Keith Menear, Caroline J. Richardson, Graeme C.M. Smith, Roger J. Griffin	2008	18
15	DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain Bioorganic & Medicinal Chemistry Letters ·K.M. Clapham, Julia Bárdos, M. Raymond V. Finlay, Bernard T. Golding, Edward J. Griffen, Roger J. Griffin, Ian R. Hardcastle, Keith Menear, Attilla Ting, Paul Turner, Gail L. Young, Céline Cano	2010	18
16	Direct thrombin inhibitors: current status and future prospects Expert Opinion on Investigational Drugs ·Keith Menear	1999	17
17	The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin Bioorganic & Medicinal Chemistry Letters ·Yasuchika Yamaguchi, Keith Menear, Nissim-Claude Cohen, Robert Mah, Frédéric Cumin, Christian Schnell, Jeanette M. Wood, Jürgen Maibaum	2009	16
18	Mechanistic rationalization of an apparently non-stereospecific intramolecular Diels-Alder reaction Tetrahedron Letters ·Philip Magnus, Clive V Walker, Paul R. Jenkins, Keith Menear	1986	14
19	Syk-deficient eosinophils show normal interleukin-5–mediated differentiation, maturation, and survival but no longer respond to FcγR activation Blood ·Estelle Lach‐Trifilieff, Keith Menear, Edina Schweighoffer, Victor L. J. Tybulewicz, Christoph Walker	2000	13
20	Purification and Characterization of Human Syk Produced Using a Baculovirus Expression System Protein Expression and Purification ·Darren Baldock, Brent Graham, Mohammed Shahid Akhlaq, Patrick Graff, Carol E. Jones, Keith Menear	2000	9

About Keith Menear

Keith Menear is a scholar working on Molecular Biology, Oncology, Organic Chemistry, Toxicology and Hematology, having authored 32 papers that have together received 1.7k indexed citations. Recurring topics across this work include Cancer therapeutics and mechanisms (9 papers), DNA Repair Mechanisms (6 papers), Bioactive Compounds and Antitumor Agents (5 papers), Chemical Synthesis and Analysis (5 papers), PARP inhibition in cancer therapy (5 papers), Blood Coagulation and Thrombosis Mechanisms (4 papers), Receptor Mechanisms and Signaling (2 papers) and Toxin Mechanisms and Immunotoxins (2 papers). The work is most often cited by research in Oncology (750 citations), Molecular Biology (1.0k citations), Organic Chemistry (391 citations), Toxicology (36 citations) and Physiology (38 citations). Keith Menear has collaborated with scholars based in United Kingdom, Switzerland and United States. Frequent co-authors include Niall M.B. Martin, Xiaoling Cockcroft, Graeme C.M. Smith, Sylvie Gomez, Marc Hummersone, Mark J. O’Connor, Frank Kerrigan, Mark Frigerio, Ian T.W. Matthews and Charlotte Knights. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Molecular Cancer Therapeutics, Biochemical Pharmacology and Cancer Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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