Frank Jacobs

3.4k citations
62 papers · 2.3k · 1 hit paper · h-index 27

Impact in

Papers in

Co-authors
Bart De Geest (44 shared papers)Eline Van Craeyveld (25 shared papers)Jan Snoeys (17 shared papers)Stephanie Gordts (17 shared papers)P.M. Frederik (2 shared papers)Ilayaraja Muthuramu (12 shared papers)E. Wisse (1 shared paper)Baki Topal (1 shared paper)
Journals
Gene Therapy (7 papers)Journal of Molecular Medicine (4 papers)International Journal of Molecular Sciences (4 papers)Current Pharmaceutical Design (4 papers)CPT Pharmacometrics & Systems Pharmacology (2 papers)
Partner nations
BelgiumUnited StatesGermany

In The Last Decade

Frank Jacobs

58 papers receiving 2.2k citations

Frank Jacobs's Hit Papers

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease 2016 · 531 citations
5310+3+6Years since publication100200300400500
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

  • it has ≥500 total citations;
  • it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
  • it reaches the top citation threshold in at least one of its specific research topics.
  1. 2016 Scientific Reports

Peers

Frank Jacobs
Comparison fields: 5 of 106
  • Hepatology 350
  • Pharmacology 204
  • Cardiology and Cardiovascular Medicine 337
  • Surgery 512
  • Cancer Research 163
Replace Tadayoshi Okumura with:
Tadayoshi Okumura Japan
Hirohisa Tsujinoue Japan
Rongqi Wang China
Kazuhiro Katayama Japan
Jianjun Zhang China
Karen Louise Thomsen Denmark
Satoshi Kobayashi Japan
J. Kar Kruijt Netherlands
Bruno Heyd France
Haoming Zhou China
Frank Jacobs relative to Tadayoshi Okumura Japan Tadayoshi Okumura's profile →
Citations per field
00.5×2×4×6.5×
Tadayoshi Okumura · 1×
Citations per year

Countries citing papers authored by Frank Jacobs

Since Specialization
Citations

This map shows the geographic impact of Frank Jacobs's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank Jacobs with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank Jacobs more than expected).

Fields of papers citing papers by Frank Jacobs

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank Jacobs. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank Jacobs. The network helps show where Frank Jacobs may publish in the future.

Co-authors

The 25 scholars most cited alongside Frank Jacobs, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Frank Jacobs Line = papers co-authored together Frank Jacobs links everyone, so they are left out of the graph.

All Works

20 of 20 papers shown

Showing the 20 most-cited of 62 papers — load more, or switch the sort, to bring in the rest.

#Work
1
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Scientific Reports ·Catherine C. Bell, Delilah Hendriks, Sabrina Moro, Ewa Ellis, Joanne Walsh, Anna Renblom, Lisa Fredriksson Puigvert, Anita C. A. Dankers, Frank Jacobs, Jan Snoeys, Rowena Sison‐Young, Rosalind E. Jenkins, Åsa Nordling, Souren Mkrtchian, B. Kevin Park, Neil R. Kitteringham, Christopher E. Goldring, Volker M. Lauschke, Magnus Ingelman‐Sundberg
Hit paper breakdown →		2016531
2
The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer
Gene Therapy ·E. Wisse, Frank Jacobs, Baki Topal, P.M. Frederik, Bart De Geest
2008237
3
The Role of Liver Sinusoidal Cells in Hepatocyte-Directed Gene Transfer
American Journal Of Pathology ·Frank Jacobs, Eddie Wisse, Bart De Geest
2009105
4
Human ApoA-I Transfer Attenuates Transplant Arteriosclerosis via Enhanced Incorporation of Bone marrow–derived Endothelial Progenitor Cells
Arteriosclerosis Thrombosis and Vascular Biology ·Yingmei Feng, Frank Jacobs, Eline Van Craeyveld, Christine Brunaud, Jan Snoeys, Marc Tjwa, Sophie Van Linthout, Bart De Geest
200769
5
Vascular-Protective Effects of High-Density Lipoprotein Include the Downregulation of the Angiotensin II Type 1 Receptor
Hypertension ·Sophie Van Linthout, Frank Spillmann, Mario Lorenz, Marco Meloni, Frank Jacobs, Marina Egorova, Verena Stangl, Bart De Geest, Heinz‐Peter Schultheiß, Carsten Tschöpe
200969
6
Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae
Gene Therapy ·Jan Snoeys, Joke Lievens, Eddie Wisse, Frank Jacobs, Hans Duimel, Désiré Collen, P.M. Frederik, Bart De Geest
200766
7
Adeno-Associated Virus Serotype 8 Gene Therapy Leads to Significant Lowering of Plasma Cholesterol Levels in Humanized Mouse Models of Homozygous and Heterozygous Familial Hypercholesterolemia
Human Gene Therapy ·Sadik H. Kassim, Hui Li, Peter Bell, Suryanarayan Somanathan, William R. Lagor, Frank Jacobs, Jeffrey T. Billheimer, James M. Wilson, Daniel J. Rader
201258
8
Critical role of scavenger receptor-BI–expressing bone marrow–derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer
Blood ·Yingmei Feng, Miranda Van Eck, Eline Van Craeyveld, Frank Jacobs, Vincent Carlier, Sophie Van Linthout, Martin Erdel, Marc Tjwa, Bart De Geest
200856
9
Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies
Journal of Molecular Medicine ·Eline Van Craeyveld, Stephanie Gordts, Elena Nefyodova, Frank Jacobs, Bart De Geest
201155
10
Direct comparison of hepatocyte-specific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer
Gene Therapy ·Frank Jacobs, Jan Snoeys, Yingmei Feng, Eline Van Craeyveld, Joke Lievens, Donna Armentano, Shuk Han Cheng, Bart De Geest
200851
11
Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
Journal of Visualized Experiments ·Ilayaraja Muthuramu, Marleen Lox, Frank Jacobs, Bart De Geest
201441
12
Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor
BioResearch open access ·Nora Freyer, Fanny Knöspel, Nadja Strahl, Leila Amini, Petra Schrade, Sebastian Bachmann, Georg Damm, Daniel Seehofer, Frank Jacobs, Mario Monshouwer, Katrin Zeilinger
201640
13
Circulating Apoptotic Endothelial Cells and Apoptotic Endothelial Microparticles Independently Predict the Presence of Cardiac Allograft Vasculopathy
Journal of the American College of Cardiology ·Neha Singh, Eline Van Craeyveld, Marc Tjwa, Agnieszka Ciarka, Jan Emmerechts, Walter Droogné, Stephanie Gordts, Vincent Carlier, Frank Jacobs, Steffen Fieuws, Johan Vanhaecke, Johan Van Cleemput, Bart De Geest
201239
14
AAV Vectors Expressing LDLR Gain-of-Function Variants Demonstrate Increased Efficacy in Mouse Models of Familial Hypercholesterolemia
Circulation Research ·Suryanarayan Somanathan, Frank Jacobs, Qiang Wang, Alexandra L. Hanlon, James M. Wilson, Daniel J. Rader
201438
15
Immunohistochemical manifestations of unilateral kidney ischemia
Clinical Transplantation ·Sherif Ibrahim, Frank Jacobs, Yakov Zukin, Debi Enriquez, David R. Holt, William M. Baldwin, Fred Sanfilippo, Lloyd E. Ratner
199638
16
Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions
Clinical Pharmacokinetics ·Marie‐Emilie Willemin, Thomas K. van der Made, Ils Pijpers, Lieve Dillen, Annett Kunze, Sophie Jonkers, Kathleen Steemans, An Tuytelaars, Frank Jacobs, Mario Monshouwer, Daniel Scotcher, Amin Rostami‐Hodjegan, Aleksandra Galetin, Jan Snoeys
202136
17
Beneficial effects of selective HDL-raising gene transfer on survival, cardiac remodelling and cardiac function after myocardial infarction in mice
Gene Therapy ·Stephanie Gordts, Ilayaraja Muthuramu, Elena Nefyodova, Frank Jacobs, Eline Van Craeyveld, Bart De Geest
201335
18
The Liver as a Target Organ for Gene Therapy: State of the Art, Challenges, and Future Perspectives
Pharmaceuticals ·Frank Jacobs, Stephanie Gordts, Ilayaraja Muthuramu, Bart De Geest
201235
19
Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress
Journal of Molecular Medicine ·Ilayaraja Muthuramu, Neha Singh, Ruhul Amin, Elena Nefyodova, Mirjam Debasse, Isa Van Horenbeeck, Frank Jacobs, Bart De Geest
201535
20
Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload
International Journal of Molecular Sciences ·Ruhul Amin, Ilayaraja Muthuramu, Joseph Pierre Aboumsallem, Mudit Mishra, Frank Jacobs, Bart De Geest
201734

About Frank Jacobs

Frank Jacobs is a scholar working on Molecular Biology, Surgery, Cardiology and Cardiovascular Medicine, Genetics and Pharmacology, having authored 62 papers that have together received 2.3k indexed citations. Recurring topics across this work include Virus-based gene therapy research (10 papers), CRISPR and Genetic Engineering (9 papers), Pharmacogenetics and Drug Metabolism (6 papers), Lipoproteins and Cardiovascular Health (6 papers), Nuclear Receptors and Signaling (5 papers), Viral gastroenteritis research and epidemiology (4 papers), Adipokines, Inflammation, and Metabolic Diseases (4 papers) and Cardiac Fibrosis and Remodeling (4 papers). The work is most often cited by research in Hepatology (350 citations), Pharmacology (204 citations), Cardiology and Cardiovascular Medicine (337 citations), Surgery (512 citations) and Cancer Research (163 citations). Frank Jacobs has collaborated with scholars based in Belgium, United States and Germany. Frequent co-authors include Bart De Geest, Eline Van Craeyveld, Jan Snoeys, Stephanie Gordts, P.M. Frederik, Ilayaraja Muthuramu, E. Wisse, Baki Topal, Eddie Wisse and Yingmei Feng. Their work appears in journals such as Gene Therapy, Journal of Molecular Medicine, International Journal of Molecular Sciences, Current Pharmaceutical Design and CPT Pharmacometrics & Systems Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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