Frank Jacobs

3.5k citations

60 papers · 2.3k · 1 hit paper · h-index 26

Impact in

Hepatology top 2%
- Liver physiology and pathology
Pharmacology top 2%
- Pharmacogenetics and Drug Metabolism

Papers in

Cardiology and Cardiovascular Medicine 14
- Cardiac Fibrosis and Remodeling 4
Pharmacology 6
- Pharmacogenetics and Drug Metabolism 6

Co-authors: Bart De Geest (42 shared papers)Eline Van Craeyveld (23 shared papers)Jan Snoeys (17 shared papers)Stephanie C. Gordts (15 shared papers)P.M. Frederik (2 shared papers)Ilayaraja Muthuramu (11 shared papers)E. Wisse (1 shared paper)Baki Topal (1 shared paper)
Journals: Gene Therapy (7 papers)Current Pharmaceutical Design (4 papers)International Journal of Molecular Sciences (4 papers)Journal of Molecular Medicine (3 papers)CPT Pharmacometrics & Systems Pharmacology (2 papers)
Partner nations: Belgium United States Germany

In The Last Decade

Frank Jacobs

57 papers receiving 2.3k citations

Frank Jacobs's Hit Papers

align trajectories log scale

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease 2016 · 559 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2016 Scientific Reports

Peers

Countries citing papers authored by Frank Jacobs

Since Specialization

Citations

This map shows the geographic impact of Frank Jacobs's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank Jacobs with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank Jacobs more than expected).

Fields of papers citing papers by Frank Jacobs

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank Jacobs. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank Jacobs. The network helps show where Frank Jacobs may publish in the future.

Co-authors

The 25 scholars most cited alongside Frank Jacobs, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Frank Jacobs Line = papers co-authored together Frank Jacobs links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 60 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease Scientific Reports ·Catherine C. Bell, Delilah F. G. Hendriks, Sabrina Moro, Ewa C. S. Ellis, Joanne Walsh, Anna Renblom, Lisa Fredriksson Puigvert, Anita C. A. Dankers, Frank Jacobs, Jan Snoeys, Rowena L. C. Sison-Young, Rosalind E. Jenkins, Åsa Nordling, Souren Mkrtchian, B. Kevin Park, Neil R. Kitteringham, Christopher E. Goldring, Volker Martin Lauschke, Magnus Ingelman‐Sundberg Hit paper breakdown →	2016	559
2	The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer Gene Therapy ·E. Wisse, Frank Jacobs, Baki Topal, P.M. Frederik, Bart De Geest	2008	255
3	The Role of Liver Sinusoidal Cells in Hepatocyte-Directed Gene Transfer American Journal Of Pathology ·Frank Jacobs, Eddie Wisse, Bart De Geest	2009	107
4	Vascular-Protective Effects of High-Density Lipoprotein Include the Downregulation of the Angiotensin II Type 1 Receptor Hypertension ·Sophie Van Linthout, Frank Spillmann, Mario Lorenz, Marco Meloni, Frank Jacobs, Marina Egorova, Verena Stangl, Bart De Geest, Heinz‐Peter Schultheiß, Carsten Tschöpe	2009	72
5	Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae Gene Therapy ·Jan Snoeys, Joke Lievens, Eddie Wisse, Frank Jacobs, Hans Duimel, Désiré Collen, P.M. Frederik, Bart De Geest	2007	70
6	Human ApoA-I Transfer Attenuates Transplant Arteriosclerosis via Enhanced Incorporation of Bone marrow–derived Endothelial Progenitor Cells Arteriosclerosis Thrombosis and Vascular Biology ·Yingmei Feng, Frank Jacobs, Eline Van Craeyveld, Christine Brunaud, Jan Snoeys, Marc Tjwa, Sophie Van Linthout, Bart De Geest	2007	69
7	Adeno-Associated Virus Serotype 8 Gene Therapy Leads to Significant Lowering of Plasma Cholesterol Levels in Humanized Mouse Models of Homozygous and Heterozygous Familial Hypercholesterolemia Human Gene Therapy ·Sadik H. Kassim, Hui Li, Peter L. Bell, Suryanarayan Somanathan, William R. Lagor, Frank Jacobs, Jeffrey T. Billheimer, James M. Wilson, Daniel James Rader	2012	59
8	Critical role of scavenger receptor-BI–expressing bone marrow–derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer Blood ·Yingmei Feng, Miranda Van Eck, Eline Van Craeyveld, Frank Jacobs, Vincent A. Carlier, Sophie Van Linthout, Martin Erdel, Marc Tjwa, Bart De Geest	2008	59
9	Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies Journal of Molecular Medicine ·Eline Van Craeyveld, Stephanie C. Gordts, Elena Nefyodova, Frank Jacobs, Bart De Geest	2011	55
10	Direct comparison of hepatocyte-specific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer Gene Therapy ·Frank Jacobs, Jan Snoeys, Yingmei Feng, Eline Van Craeyveld, Joke Lievens, Donna Armentano, Shuk Han Cheng, Bart De Geest	2008	53
11	Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure Journal of Visualized Experiments ·Ilayaraja Muthuramu, Marleen Lox, Frank Jacobs, Bart De Geest	2014	43
12	Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor BioResearch open access ·Nora Freyer, Fanny Knöspel, Nadja Strahl, Leila Amini, Petra Schrade, Sebastian Bachmann, Georg Damm, Daniel Seehofer, Frank Jacobs, Mario Monshouwer, Katrin Zeilinger	2016	43
13	Circulating Apoptotic Endothelial Cells and Apoptotic Endothelial Microparticles Independently Predict the Presence of Cardiac Allograft Vasculopathy Journal of the American College of Cardiology ·Neha Singh, Eline Van Craeyveld, Marc Tjwa, Agnieszka Ciarka, Jan Emmerechts, Walter Droogné, Stephanie C. Gordts, Vincent A. Carlier, Frank Jacobs, Steffen Fieuws, Johan Vanhaecke, Johan Van Cleemput, Bart De Geest	2012	42
14	AAV Vectors Expressing LDLR Gain-of-Function Variants Demonstrate Increased Efficacy in Mouse Models of Familial Hypercholesterolemia Circulation Research ·Suryanarayan Somanathan, Frank Jacobs, Qiang Wang, Alexandra L. Hanlon, James M. Wilson, Daniel James Rader	2014	42
15	Immunohistochemical manifestations of unilateral kidney ischemia Clinical Transplantation ·Sherif Ibrahim, Frank Jacobs, Yakov Zukin, Debi Enriquez, David R. Holt, William M. Baldwin, Fred P. Sanfilippo, Lloyd E. Ratner	1996	39
16	Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions Clinical Pharmacokinetics ·Marie‐Emilie Willemin, Thomas K. van der Made, Ils Pijpers, Lieve Dillen, Annett Kunze, Sophie Jonkers, Kathleen Steemans, An Tuytelaars, Frank Jacobs, Mario Monshouwer, Daniel Scotcher, Amin Rostami‐Hodjegan, Aleksandra Galetin, Jan Snoeys	2021	37
17	Beneficial effects of selective HDL-raising gene transfer on survival, cardiac remodelling and cardiac function after myocardial infarction in mice Gene Therapy ·Stephanie C. Gordts, Ilayaraja Muthuramu, Elena Nefyodova, Frank Jacobs, Eline Van Craeyveld, Bart De Geest	2013	37
18	The Liver as a Target Organ for Gene Therapy: State of the Art, Challenges, and Future Perspectives Pharmaceuticals ·Frank Jacobs, Stephanie C. Gordts, Ilayaraja Muthuramu, Bart De Geest	2012	37
19	Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload International Journal of Molecular Sciences ·Ruhul Amin, Ilayaraja Muthuramu, Joseph Pierre Aboumsallem, Mudit Mishra, Frank Jacobs, Bart De Geest	2017	36
20	Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress Journal of Molecular Medicine ·Ilayaraja Muthuramu, Neha Singh, Ruhul Amin, Elena Nefyodova, Mirjam Debasse, Isa Van Horenbeeck, Frank Jacobs, Bart De Geest	2015	35

About Frank Jacobs

Frank Jacobs is a scholar working on Cardiology and Cardiovascular Medicine, Pharmacology, Genetics, Surgery and Molecular Biology, having authored 60 papers that have together received 2.3k indexed citations. Recurring topics across this work include Virus-based gene therapy research (10 papers), CRISPR and Genetic Engineering (9 papers), Pharmacogenetics and Drug Metabolism (6 papers), Lipoproteins and Cardiovascular Health (5 papers), Adipokines, Inflammation, and Metabolic Diseases (4 papers), Cardiac Fibrosis and Remodeling (4 papers), Viral gastroenteritis research and epidemiology (4 papers) and Drug Transport and Resistance Mechanisms (4 papers). The work is most often cited by research in Hepatology (366 citations), Pharmacology (209 citations), Cardiology and Cardiovascular Medicine (344 citations), Surgery (514 citations) and Cancer Research (170 citations). Frank Jacobs has collaborated with scholars based in Belgium, United States and Germany. Frequent co-authors include Bart De Geest, Eline Van Craeyveld, Jan Snoeys, Stephanie C. Gordts, P.M. Frederik, Ilayaraja Muthuramu, E. Wisse, Baki Topal, Eddie Wisse and Yingmei Feng. Their work appears in journals such as Gene Therapy, Current Pharmaceutical Design, International Journal of Molecular Sciences, Journal of Molecular Medicine and CPT Pharmacometrics & Systems Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Frank Jacobs's Hit Papers

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