Anke Klippel

9.7k citations

67 papers · 8.0k · 3 hit papers · h-index 40

Impact in

Molecular Biology top 0.5%
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
Cell Biology top 0.5%
- Cellular transport and secretion

Papers in

Molecular Biology 58
- Protein Kinase Regulation and GTPase Signaling 22
- PI3K/AKT/mTOR signaling in cancer 14
- Protein Degradation and Inhibitors 10
- Ubiquitin and proteasome pathways 8
- Cell death mechanisms and regulation 5
Oncology 14

Co-authors: Lewis T. Williams (15 shared papers)George Kulik (1 shared paper)Michael J. Weber (1 shared paper)W. Michael Kavanaugh (4 shared papers)Christoph Reinhard (2 shared papers)Wendy J. Fantl (4 shared papers)Qianjin Hu (3 shared papers)Anthony J. Muslin (2 shared papers)
Journals: Molecular and Cellular Biology (14 papers)Blood (9 papers)The EMBO Journal (6 papers)Journal of Biological Chemistry (6 papers)Oncogene (4 papers)
Partner nations: United States Germany Switzerland

In The Last Decade

Anke Klippel

67 papers receiving 7.8k citations

Anke Klippel's Hit Papers

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Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 ^CRBN 2013 · 463 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2013 British Journal of Haematology
1997 Science
1997 Molecular and Cellular Biology

Peers

Countries citing papers authored by Anke Klippel

Since Specialization

Citations

This map shows the geographic impact of Anke Klippel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Anke Klippel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Anke Klippel more than expected).

Fields of papers citing papers by Anke Klippel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Anke Klippel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Anke Klippel. The network helps show where Anke Klippel may publish in the future.

Co-authors

The 25 scholars most cited alongside Anke Klippel, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Anke Klippel Line = papers co-authored together Anke Klippel links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 67 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis Science ·Srinivas Kothakota, Toshifumi Azuma, Christoph Reinhard, Anke Klippel, Jay X. Tang, Keting Chu, Thomas J. McGarry, Marc W. Kirschner, Kirston Koths, David J. Kwiatkowski, Lewis T. Williams Hit paper breakdown →	1997	1001
2	Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt Molecular and Cellular Biology ·George Kulik, Anke Klippel, Michael J. Weber Hit paper breakdown →	1997	933
3	Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase Science ·Qianjin Hu, Anke Klippel, Anthony J. Muslin, Wendy J. Fantl, Lewis T. Williams	1995	497
4	Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 ^CRBN British Journal of Haematology ·Anita K. Gandhi, Jian Kang, Courtney G. Havens, Thomas A. Conklin, Yuhong Ning, Lei Wu, Takumi Ito, Hideki Ando, Michelle F. Waldman, Anjan Thakurta, Anke Klippel, Hiroshi Handa, Thomas O. Daniel, Peter Schäfer, Rajesh Chopra Hit paper breakdown →	2013	463
5	A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain Molecular and Cellular Biology ·Anke Klippel, W. Michael Kavanaugh, David Pot, Lewis T. Williams	1997	423
6	Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways Molecular and Cellular Biology ·Anke Klippel, Christoph Reinhard, W. Michael Kavanaugh, Gerald Apell, Maria-Amelia Escobedo, Lewis T. Williams	1996	396
7	A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium Gene Therapy ·Ansgar Santel, Manuela Aleku, Oliver Keil, Jens Endruschat, V Esche, Gerald Fisch, Sibylle Dames, Kathrin Löffler, Melanie Fechtner, W. Arnold, Klaus Giese, Anke Klippel, Jörg Kaufmann	2006	304
8	Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation Molecular and Cellular Biology ·Anke Klippel, Maria-Amelia Escobedo, Matthew S. Wachowicz, Gerald Apell, Timothy W. Brown, Martin Giedlin, W. Michael Kavanaugh, Lewis T. Williams	1998	233
9	Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5. Proceedings of the National Academy of Sciences ·Guangfu Li, Crislyn D’Souza‐Schorey, M. Alejandro Barbieri, Richard Roberts, Anke Klippel, L T Williams, Philip D. Stahl	1995	229
10	Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons The Journal of Cell Biology ·Karen L. Philpott, Mary Jane McCarthy, Anke Klippel, Lee L. Rubin	1997	220
11	Activated Phosphatidylinositol 3-Kinase Is Sufficient to Mediate Actin Rearrangement and GLUT4 Translocation in 3T3-L1 Adipocytes Journal of Biological Chemistry ·Stuart S. Martin, Tetsuro Haruta, Aaron J. Morris, Anke Klippel, Lewis T. Williams, Jerrold M. Olefsky	1996	218
12	Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proceedings of the National Academy of Sciences ·Q P Weng, Khurshid Iqbal Andrabi, Anke Klippel, Mark T. Kozlowski, L T Williams, Joseph Avruch	1995	190
13	Rate of CRL4CRBN substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4 Blood Cancer Journal ·Chad C. Bjorklund, Ling Lu, Jian Kang, Patrick R. Hagner, Courtney G. Havens, Michael Amatangelo, M Wang, Yan Ren, Suzana S. Couto, Michael A. Breider, Yuhong Ning, Anita K. Gandhi, Tom Daniel, Rajesh Chopra, Anke Klippel, Anjan Thakurta	2015	158
14	Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence Journal of Biological Chemistry ·Stephen B. Cichy, Shahab Uddin, Alexey Danilkovich, Shaodong Guo, Anke Klippel, Terry G. Unterman	1998	150
15	RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy Gene Therapy ·Ansgar Santel, Manuela Aleku, Oliver Keil, Jens Endruschat, V Esche, Birgit Durieux, Kathrin Löffler, Melanie Fechtner, Thomas Röhl, Gerald Fisch, Sibylle Dames, W. Arnold, Klaus Giese, Anke Klippel, Jörg Kaufmann	2006	148
16	Overexpression of a Constitutively Active Form of Phosphatidylinositol 3-Kinase Is Sufficient to Promote Glut 4 Translocation in Adipocytes Journal of Biological Chemistry ·Jean‐François Tanti, Thierry Grémeaux, Sophie Grillo, Véronique Calleja, Anke Klippel, Lewis T. Williams, Emmanuel Van Obberghen, Y. Le Marchand‐Brustel	1996	138
17	The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor. Molecular and Cellular Biology ·Anke Klippel, J A Escobedo, Wendy J. Fantl, L T Williams	1992	134
18	The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Molecular and Cellular Biology ·Anke Klippel, J A Escobedo, Tatsuya Hirano, L T Williams	1994	126
19	Knockdown of MTP18, a Novel Phosphatidylinositol 3-Kinase-dependent Protein, Affects Mitochondrial Morphology and Induces Apoptosis Journal of Biological Chemistry ·Daniel Tondera, Ansgar Santel, Rolf Schwarzer, Sybille Dames, Klaus Giese, Anke Klippel, Jörg Kaufmann	2004	124
20	Differential regulation of TGF-β signaling through Smad2, Smad3 and Smad4 Oncogene ·Anny Kretschmer, Kristin Moepert, Sibylle Dames, Maria Sternberger, Joerg Kaufmann, Anke Klippel	2003	115

About Anke Klippel

Anke Klippel is a scholar working on Molecular Biology, Oncology, Cell Biology, Hematology and Cancer Research, having authored 67 papers that have together received 8.0k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (22 papers), PI3K/AKT/mTOR signaling in cancer (14 papers), Multiple Myeloma Research and Treatments (10 papers), Protein Degradation and Inhibitors (10 papers), Ubiquitin and proteasome pathways (8 papers), Cellular transport and secretion (8 papers), Cell death mechanisms and regulation (5 papers) and Bacteriophages and microbial interactions (5 papers). The work is most often cited by research in Molecular Biology (6.0k citations), Cell Biology (1.2k citations), Cancer Research (776 citations), Hematology (500 citations) and Immunology (937 citations). Anke Klippel has collaborated with scholars based in United States, Germany and Switzerland. Frequent co-authors include Lewis T. Williams, George Kulik, Michael J. Weber, W. Michael Kavanaugh, Christoph Reinhard, Wendy J. Fantl, Qianjin Hu, Anthony J. Muslin, David Pot and J A Escobedo. Their work appears in journals such as Molecular and Cellular Biology, Blood, The EMBO Journal, Journal of Biological Chemistry and Oncogene.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Anke Klippel

Anke Klippel's Hit Papers

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About Anke Klippel

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