J.R. Mitchell

4.5k citations

32 papers · 3.5k · 1 hit paper · h-index 22

Impact in

Pharmacology top 0.05%
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
Hepatology top 1%
- Liver Disease and Transplantation

Papers in

Pharmacology 12
- Drug-Induced Hepatotoxicity and Protection 10
- Antibiotics Pharmacokinetics and Efficacy 3
- Pharmacogenetics and Drug Metabolism 3
Molecular Biology 7
- Phenothiazines and Benzothiazines Synthesis and Activities 3

Co-authors: David J. Jollow (5 shared papers)James R. Gillette (5 shared papers)B.B. Brodie (2 shared papers)William Z. Potter (1 shared paper)Charles V. Smith (6 shared papers)Helen MacGill Hughes (8 shared papers)B H Lauterburg (6 shared papers)George B. Corcoran (4 shared papers)
Journals: Journal of Pharmacology and Experimental Therapeutics (7 papers)Analytical Biochemistry (2 papers)Trends in Pharmacological Sciences (2 papers)Advances in experimental medicine and biology (2 papers)Journal of Clinical Investigation (2 papers)
Partner nations: United States

In The Last Decade

J.R. Mitchell

32 papers receiving 3.3k citations

J.R. Mitchell's Hit Papers

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ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE 1973 · 1.5k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1973 Journal of Pharmacology and Experimental Therapeutics

Peers

Countries citing papers authored by J.R. Mitchell

Since Specialization

Citations

This map shows the geographic impact of J.R. Mitchell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by J.R. Mitchell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites J.R. Mitchell more than expected).

Fields of papers citing papers by J.R. Mitchell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by J.R. Mitchell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by J.R. Mitchell. The network helps show where J.R. Mitchell may publish in the future.

Co-authors

The 25 scholars most cited alongside J.R. Mitchell, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with J.R. Mitchell Line = papers co-authored together J.R. Mitchell links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 32 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE Journal of Pharmacology and Experimental Therapeutics ·J.R. Mitchell, David J. Jollow, William Z. Potter, James R. Gillette, B.B. Brodie Hit paper breakdown →	1973	1496
2	Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver. Journal of Clinical Investigation ·Hartmut Jaeschke, Charles V. Smith, J.R. Mitchell	1988	196
3	Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat Science ·Sidney D. Nelson, J.R. Mitchell, John A. Timbrell, Wayne R. Snodgrass, George B. Corcoran	1976	191
4	ROLE OF DETOXIFYING ENZYMES IN BROMOBENZENE-INDUCED LIVER NECROSIS Journal of Pharmacology and Experimental Therapeutics ·Nicola Zampaglione, David J. Jollow, J.R. Mitchell, Barry R. Stripp, Maynard E. Hamrick, James R. Gillette	1973	174
5	Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice. Journal of Pharmacology and Experimental Therapeutics ·George B. Corcoran, William J. Racz, Charles V. Smith, J.R. Mitchell	1985	154
6	Biliary excretion of glutathione and glutathione disulfide in the rat. Regulation and response to oxidative stress. Journal of Clinical Investigation ·B H Lauterburg, Charles V. Smith, Helen MacGill Hughes, J.R. Mitchell	1984	150
7	Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. Journal of Lipid Research ·ML Lenz, Helen MacGill Hughes, J.R. Mitchell, DP Via, JR Guyton, Addison A. Taylor, AM Gotto, CV Smith	1990	132
8	Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis. PubMed ·Erik Dybing, Sidney D. Nelson, J.R. Mitchell, Hènry A. Sasame, James R. Gillette	1976	130
9	Age-dependence of hypertensive-normotensive differences in plasma norepinephrine. Hypertension ·David S. Goldstein, C. Raymond Lake, Bart Chernow, Michael G. Ziegler, Michael D. Coleman, Addison A. Taylor, J.R. Mitchell, Irwin J. Kopin, Harry R. Keiser	1983	106
10	DRUG METABOLISM AS A CAUSE OF DRUG TOXICITY Drug Metabolism and Disposition ·J.R. Mitchell, David J. Jollow, J R Gillette, B.B. Brodie	1973	100
11	The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis. Journal of Pharmacology and Experimental Therapeutics ·B H Lauterburg, Y. N. Vaishnav, W.G. Stillwell, J.R. Mitchell	1980	89
12	Oxidant stress and hepatic necrosis in rats treated with diquat. Journal of Pharmacology and Experimental Therapeutics ·Charles V. Smith, Helen MacGill Hughes, B H Lauterburg, J.R. Mitchell	1985	79
13	High-performance liquid chromatography and gas chromatography-mass spectrometry determination of specific lipid peroxidation products in vivo Analytical Biochemistry ·Helen MacGill Hughes, Charles V. Smith, E. C. Horning, J.R. Mitchell	1983	77
14	Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography Analytical Biochemistry ·Alan R. Buckpitt, Douglas E. Rollins, Sidney D. Nelson, Ronald B. Franklin, J.R. Mitchell	1977	77
15	Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice. Journal of Pharmacology and Experimental Therapeutics ·George B. Corcoran, E L Todd, William J. Racz, Hettie B. Hughes, Caroline Smith, J.R. Mitchell	1985	67
16	Acetaminophen-Induced Hepatic Necrosis V. Correlation of Hepatic Necrosis, Covalent Binding and Glutathione Depletion in Hamsters Pharmacology ·William Z. Potter, S.S. Thorgeirsson, David J. Jollow, J.R. Mitchell	2008	58
17	High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma Journal of Chromatography B Biomedical Sciences and Applications ·S. C. Montamat, D. R. Abernethy, J.R. Mitchell	1987	33
18	Chemical Nature of Reactive Intermediates as Determinant of Toxicologic Responses Drug Metabolism Reviews ·J.R. Mitchell, Helen MacGill Hughes, B H Lauterburg, Charles V. Smith	1982	33
19	Microsomal N-Hydroxylation of p-Chloroacetanilide Molecular Pharmacology ·J. A. Hinson, J.R. Mitchell, David J. Jollow	1975	31
20	Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury. Journal of Pharmacology and Experimental Therapeutics ·Scott B. Shappell, Addison A. Taylor, Helen MacGill Hughes, J.R. Mitchell, D C Anderson, Colin Smith	1990	31

About J.R. Mitchell

J.R. Mitchell is a scholar working on Pharmacology, Molecular Biology, Biochemistry, Hepatology and Organic Chemistry, having authored 32 papers that have together received 3.5k indexed citations. Recurring topics across this work include Drug-Induced Hepatotoxicity and Protection (10 papers), Liver physiology and pathology (3 papers), Antibiotics Pharmacokinetics and Efficacy (3 papers), Pharmacogenetics and Drug Metabolism (3 papers), Phenothiazines and Benzothiazines Synthesis and Activities (3 papers), Eicosanoids and Hypertension Pharmacology (3 papers), Liver Disease and Transplantation (3 papers) and Liver Disease Diagnosis and Treatment (2 papers). The work is most often cited by research in Pharmacology (2.0k citations), Hepatology (526 citations), Biochemistry (456 citations), Oncology (634 citations) and Biochemistry (141 citations). J.R. Mitchell has collaborated with scholars based in United States. Frequent co-authors include David J. Jollow, James R. Gillette, B.B. Brodie, William Z. Potter, Charles V. Smith, Helen MacGill Hughes, B H Lauterburg, George B. Corcoran, Sidney D. Nelson and Charles V. Smith. Their work appears in journals such as Journal of Pharmacology and Experimental Therapeutics, Analytical Biochemistry, Trends in Pharmacological Sciences, Advances in experimental medicine and biology and Journal of Clinical Investigation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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J.R. Mitchell

J.R. Mitchell's Hit Papers

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