David M. Fram

1.7k citations

29 papers · 1.3k · 1 hit paper · h-index 17

Impact in

Toxicology top 0.5%
- Pharmacovigilance and Adverse Drug Reactions
Applied Microbiology and Biotechnology top 5%
- Antibiotic Use and Resistance

Papers in

Toxicology 14
- Pharmacovigilance and Adverse Drug Reactions 14
Epidemiology 12
- Sepsis Diagnosis and Treatment 11
- Data-Driven Disease Surveillance 1

Co-authors: Sameer S. Kadri (10 shared papers)Michael Klompas (10 shared papers)Chanu Rhee (10 shared papers)William DuMouchel (9 shared papers)June S. Almenoff (7 shared papers)Huai-Chun Chen (5 shared papers)Robert L. Danner (1 shared paper)Fang Zhang (1 shared paper)
Journals: Critical Care Medicine (5 papers)JAMA Network Open (3 papers)Drug Safety (2 papers)Pharmacoepidemiology and Drug Safety (2 papers)Open Forum Infectious Diseases (2 papers)
Partner nations: United States United Kingdom Canada

In The Last Decade

David M. Fram

29 papers receiving 1.2k citations

David M. Fram's Hit Papers

align trajectories log scale

Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use 2020 · 288 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2020 JAMA Network Open

Peers

Countries citing papers authored by David M. Fram

Since Specialization

Citations

This map shows the geographic impact of David M. Fram's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David M. Fram with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David M. Fram more than expected).

Fields of papers citing papers by David M. Fram

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David M. Fram. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David M. Fram. The network helps show where David M. Fram may publish in the future.

Co-authors

The 25 scholars most cited alongside David M. Fram, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David M. Fram Line = papers co-authored together David M. Fram links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 29 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use JAMA Network Open ·Chanu Rhee, Sameer S. Kadri, John P. Dekker, Robert L. Danner, Huai-Chun Chen, David M. Fram, Fang Zhang, Michael Klompas +1 other Hit paper breakdown →	2020	288
2	Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients* Critical Care Medicine ·Dominique J. Pepper, Cumhur Y. Demirkale, Junfeng Sun, Chanu Rhee, David M. Fram, Peter Q. Eichacker, Michael Klompas, Anthony F. Suffredini	2019	131
3	Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria* Critical Care Medicine ·Chanu Rhee, Zilu Zhang, Sameer S. Kadri, David J. Murphy, Greg Martin, Elizabeth C. Overton, Christopher W. Seymour, Derek C. Angus	2019	101
4	Disproportionality analysis using empirical Bayes data mining: a tool for the evaluation of drug interactions in the post‐marketing setting Pharmacoepidemiology and Drug Safety ·June S. Almenoff, William DuMouchel, L. Allen Kindman, Xionghu Yang, David M. Fram	2003	98
5	Comparative Performance of Two Quantitative Safety Signalling Methods Drug Safety ·June S. Almenoff, Karol LaCroix, Nancy Yuen, David M. Fram, William DuMouchel	2006	90
6	Epidemiology of Hospital-Onset Versus Community-Onset Sepsis in U.S. Hospitals and Association With Mortality: A Retrospective Analysis Using Electronic Clinical Data Critical Care Medicine ·Chanu Rhee, Rui Wang, Zilu Zhang, David M. Fram, Sameer S. Kadri, Michael Klompas	2019	83
7	Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons* Critical Care Medicine ·Chanu Rhee, Maximilian S. Jentzsch, Sameer S. Kadri, Christopher W. Seymour, Derek C. Angus, David J. Murphy, Greg Martin, Raymund Dantes	2018	65
8	Association Between Implementation of the Severe Sepsis and Septic Shock Early Management Bundle Performance Measure and Outcomes in Patients With Suspected Sepsis in US Hospitals JAMA Network Open ·Chanu Rhee, Tingting Yu, Rui Wang, Sameer S. Kadri, David M. Fram, Huai-Chun Chen, Michael Klompas	2021	57
9	Association of asthma therapy and churg-strauss syndrome: An analysis of postmarketing surveillance data Clinical Therapeutics ·William DuMouchel, Eric T. Smith, Richard W. Beasley, Harold S. Nelson, Xionghu Yang, David M. Fram, June S. Almenoff	2004	54
10	Empirical Bayesian data mining for discovering patterns in post-marketing drug safety ACM SIGKDD International Conference on Knowledge Discovery and Data Mining (KDD) ·David M. Fram, June S. Almenoff, William DuMouchel	2003	34
11	Adaptation of Bayesian Data Mining Algorithms to Longitudinal Claims Data Medical Care ·Jeffrey R. Curtis, Hong Ming Cheng, Elizabeth Delzell, David M. Fram, Meredith L. Kilgore, Kenneth G. Saag, Huifeng Yun, William DuMouchel	2008	33
12	Antipsychotics, Glycemic Disorders, and Life-Threatening Diabetic Events: A Bayesian Data-Mining Analysis of the FDA Adverse Event Reporting System (1968-2004) Annals of Clinical Psychiatry ·William DuMouchel, David M. Fram, Xionghu Yang, Ramy A. Mahmoud, Amy L. Grogg, Luella Engelhart, Krishnan Ramaswamy	2008	31
13	Trends in Empiric Broad-Spectrum Antibiotic Use for Suspected Community-Onset Sepsis in US Hospitals JAMA Network Open ·Chanu Rhee, Tom Chen, Sameer S. Kadri, Alexander Lawandi, Christina Yek, Morgan K. Walker, Sarah R. Warner, David M. Fram	2024	31
14	Signal detection methodologies to support effective safety management Expert Opinion on Drug Safety ·Robbert P. van Manen, David M. Fram, William DuMouchel	2007	27
15	The implementation of the PROPHET system Paul A. Castleman, Channing H. Russell, Frederick N. Webb, S. R. Zdoxik, David M. Fram +2 others	1974	24
16	Using simulation to assess the sensitivity and specificity of a signal detection tool for multidimensional public health surveillance data Statistics in Medicine ·Henry R. Rolka, Channing Russell, David M. Fram, Robert Ball +1 other	2005	21
17	Epidemiology and Outcomes of Antibiotic De-escalation in Patients With Suspected Sepsis in US Hospitals Clinical Infectious Diseases ·Kai‐Qian Kam, Tom Chen, Sameer S. Kadri, Alexander Lawandi, Christina Yek, Morgan K. Walker, Sarah R. Warner, David M. Fram	2024	17
18	Development of a mother-child database for drug exposure and adverse event detection in the Military Health System Pharmacoepidemiology and Drug Safety ·Lockwood G. Taylor, Rosenie Thelus Jean, Geoff Gordon, David M. Fram, Trinka S. Coster	2015	15
19	Risk Adjustment for Sepsis Mortality to Facilitate Hospital Comparisons Using Centers for Disease Control and Prevention’s Adult Sepsis Event Criteria and Routine Electronic Clinical Data Critical Care Explorations ·Chanu Rhee, Rui Wang, Zilu Zhang, Sameer S. Kadri, Edward Joel Septimus, David M. Fram, Robert Jin, Jason D. Hickok	2019	13
20	Molecular clinical safety intelligence: a system for bridging clinically focused safety knowledge to early-stage drug discovery – the GSK experience Drug Discovery Today ·Dana E. Vanderwall, Nancy Yuen, Mohammad Basim Al-Ansari, James M. Bailey, David M. Fram, Darren V. S. Green, Stephen D. Pickett, Juan I. Luengo	2011	8

About David M. Fram

David M. Fram is a scholar working on Toxicology, Epidemiology, Applied Microbiology and Biotechnology, Software and Information Systems and Management, having authored 29 papers that have together received 1.3k indexed citations. Recurring topics across this work include Pharmacovigilance and Adverse Drug Reactions (14 papers), Sepsis Diagnosis and Treatment (11 papers), Antibiotic Use and Resistance (3 papers), Engineering and Information Technology (2 papers), Scientific Computing and Data Management (2 papers), Decision Support System Applications (1 paper), Data Visualization and Analytics (1 paper) and Data-Driven Disease Surveillance (1 paper). The work is most often cited by research in Toxicology (322 citations), Applied Microbiology and Biotechnology (100 citations), Epidemiology (514 citations), Clinical Biochemistry (64 citations) and Critical Care and Intensive Care Medicine (40 citations). David M. Fram has collaborated with scholars based in United States, United Kingdom and Canada. Frequent co-authors include Sameer S. Kadri, Michael Klompas, Chanu Rhee, William DuMouchel, June S. Almenoff, Huai-Chun Chen, Robert L. Danner, Fang Zhang, John P. Dekker and Zilu Zhang. Their work appears in journals such as Critical Care Medicine, JAMA Network Open, Drug Safety, Pharmacoepidemiology and Drug Safety and Open Forum Infectious Diseases.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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David M. Fram

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In The Last Decade

David M. Fram

David M. Fram's Hit Papers

Peers

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All Works

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