Patrick A. Lewis

21.9k citations

130 papers · 6.2k · 2 hit papers · h-index 39

Impact in

Neurology top 0.2%
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Neurological disorders and treatments
Cellular and Molecular Neuroscience top 1%
- Nuclear Receptors and Signaling

Papers in

Neurology 61
- Parkinson's Disease Mechanisms and Treatments 61
- Neurological diseases and metabolism 14
- Neurological disorders and treatments 9
Molecular Biology 52

Co-authors: John Hardy (32 shared papers)Mark Cookson (22 shared papers)Claudia Manzoni (30 shared papers)Elisa Greggio (16 shared papers)Alexandra Beilina (9 shared papers)Nicholas Wood (5 shared papers)Andrew J. Lees (7 shared papers)Andrew Singleton (7 shared papers)
Journals: Neurobiology of Disease (5 papers)FEBS Journal (4 papers)Journal of Neurochemistry (4 papers)Molecular Neurodegeneration (4 papers)Journal of Biological Chemistry (3 papers)
Partner nations: United Kingdom United States Italy

In The Last Decade

Patrick A. Lewis

122 papers receiving 6.1k citations

Patrick A. Lewis's Hit Papers

align trajectories log scale

Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences 2016 · 484 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2016 Briefings in Bioinformatics
2006 Neurobiology of Disease

Peers

Countries citing papers authored by Patrick A. Lewis

Since Specialization

Citations

This map shows the geographic impact of Patrick A. Lewis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick A. Lewis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick A. Lewis more than expected).

Fields of papers citing papers by Patrick A. Lewis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick A. Lewis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick A. Lewis. The network helps show where Patrick A. Lewis may publish in the future.

Co-authors

The 25 scholars most cited alongside Patrick A. Lewis, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Patrick A. Lewis Line = papers co-authored together Patrick A. Lewis links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Showing the 20 most-cited of 130 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Kinase activity is required for the toxic effects of mutant LRRK2/dardarin Neurobiology of Disease ·Elisa Greggio, Shushant Jain, Ann E. Kingsbury, Rina Bandopadhyay, Patrick A. Lewis, Alice Kaganovich, Marcel P. van der Brug, Alexandra Beilina, Jeff Blackinton, Kelly Jean Thomas Craig, Rili Ahmad, David W. Miller, Sashi Kesavapany, Andrew Singleton, Andrew J. Lees, Victoria L. Harvey, Kirsten Harvey, Mark Cookson Hit paper breakdown →	2006	591
2	Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences Briefings in Bioinformatics ·Claudia Manzoni, Demis A. Kia, Jana Vandrovcová, John Hardy, Nicholas Wood, Patrick A. Lewis, Raffaele Ferrari Hit paper breakdown →	2016	484
3	Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus Nature Communications ·Michael J. Devine, Mina Ryten, Petr Vodička, Alison J. Thomson, Tom Burdon, Henry Houlden, Fatima Cavaleri, Masumi Nagano, Nicola J. Drummond, Jan‐Willem Taanman, Anthony H.V. Schapira, Katrina Gwinn, John Hardy, Patrick A. Lewis, Tilo Kunath	2011	375
4	α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy? Acta Neuropathologica ·Aoife P. Kiely, Yasmine T. Asi, Eleanna Kara, Patricia Limousin, Helen Ling, Patrick A. Lewis, Christos Proukakis, Niall Quinn, Andrew J. Lees, John Hardy, Tamás Révész, Henry Houlden, Janice L. Holton	2013	349
5	The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation Journal of Biological Chemistry ·Elisa Greggio, Ibardo Zambrano, Alice Kaganovich, Alexandra Beilina, Jean‐Marc Taymans, Veronique Daniëls, Patrick A. Lewis, Shushant Jain, Jinhui Ding, Ali Syed, Kelly Jean Thomas Craig, Veerle Baekelandt, Mark Cookson	2008	244
6	The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy Nature Neuroscience ·Victoria Burchell, David E. Nelson, Álvaro Sánchez-Martínez, Marta Delgado-Camprubi, Rachael M. Ivatt, Joe H. Pogson, Suzanne J. Randle, Selina Wray, Patrick A. Lewis, Henry Houlden, Andrey Y. Abramov, John Hardy, Nicholas Wood, Alexander J. Whitworth, Heike Laman, Hélène Plun‐Favreau	2013	243
7	The R1441C mutation of LRRK2 disrupts GTP hydrolysis Biochemical and Biophysical Research Communications ·Patrick A. Lewis, Elisa Greggio, Alexandra Beilina, Shushant Jain, Acacia K. Baker, Mark Cookson	2007	214
8	Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase Proceedings of the National Academy of Sciences ·Junpeng Deng, Patrick A. Lewis, Elisa Greggio, Eli Sluch, Alexandra Beilina, Mark Cookson	2008	189
9	The genetics of Parkinson's syndromes: a critical review Current Opinion in Genetics & Development ·John Hardy, Patrick A. Lewis, Tamás Révész, Andrew J. Lees, Coro Paisán‐Ruiz	2009	155
10	DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA The Lancet Neurology ·Sarah Camargos, Sonja W. Scholz, Javier Simón‐Sánchez, Coro Paisán‐Ruíz, Patrick A. Lewis, Dena G. Hernandez, Jinhui Ding, J. Raphael Gibbs, Mark Cookson, José Brás, Rita Guerreiro, Catarina R. Oliveira, Andrew J. Lees, John Hardy, Francisco Cardoso, Andrew Singleton	2008	143
11	Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea PLoS Genetics ·Hélène Plun‐Favreau, Patrick A. Lewis, John Hardy, L. Miguel Martins, Nicholas Wood	2010	141
12	LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages The EMBO Journal ·Anetta Härtlová, Susanne Herbst, Julien Peltier, Angela Rodgers, Orsolya Bilkei‐Gorzo, Antony Fearns, Brian D. Dill, Heyne Lee, Rowan Flynn, Sally A. Cowley, Paul Davies, Patrick A. Lewis, Ian G. Ganley, Jennifer Martinez, Dario R. Alessi, Alastair D. Reith, Matthias Trost, Maximiliano G. Gutiérrez	2018	126
13	Inhibition of LRRK2 kinase activity stimulates macroautophagy Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Claudia Manzoni, Adamantios Mamais, Sybille Dihanich, Rosella Abeti, Marc P. M. Soutar, Hélène Plun‐Favreau, Paola Giunti, Sharon A. Tooze, Rina Bandopadhyay, Patrick A. Lewis	2013	119
14	Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration Human Molecular Genetics ·Elpida Tsika, Liliane Glauser, Ralf Moser, Aris Fiser, Guillaume Daniel, Una‐Marie Sheerin, Andrew J. Lees, Juan C. Troncoso, Patrick A. Lewis, Rina Bandopadhyay, Bernard L. Schneider, Darren J. Moore	2014	117
15	Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study PLoS Medicine ·Alastair J. Noyce, Demis A. Kia, Gibran Hemani, Aude Nicolas, T. Ryan Price, Eduardo De Pablo‐Fernández, Philip Haycock, Patrick A. Lewis, Thomas Foltynie, George Davey Smith, Anette Schrag, Andrew Lees, John Hardy, Andrew Singleton, Mike A. Nalls, Neil Pearce, Debbie A. Lawlor, Nicholas Wood	2017	114
16	LRRK2: Cause, Risk, and Mechanism Journal of Parkinson s Disease ·Coro Paisán‐Ruíz, Patrick A. Lewis, Andrew Singleton	2013	110
17	Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase Journal of Neuroscience ·Amritpal Mudher, Susan C. Chapman, Jill Richardson, Ayodeji A. Asuni, Graham Gibb, Claire C. Pollard, Richard Killick, Tasfia Ahmed Iqbal, Lynn A. Raymond, Ian M. Varndell, Paul W. Sheppard, Andrew Makoff, Elaine Gower, Peter E. Soden, Patrick A. Lewis, Michael P. Murphy, Todd E. Golde, H. Thomas Rupniak, Brian H. Anderton, Simon Lovestone	2001	103
18	Cell‐free assays for γ‐secretase activity The FASEB Journal ·Chris McLendon, Tianpei A. Xin, Chewki Ziani‐Cherif, M. Paul Murphy, Kirk A. Findlay, Patrick A. Lewis, Inga Pinnix, Kumar Sambamurti, Rong Wang, Abdul H. Fauq, Todd E. Golde	2000	94
19	Presenilin 1 Regulates Pharmacologically Distinct γ-Secretase Activities Journal of Biological Chemistry ·M. Paul Murphy, Sacha Uljon, Paul E. Fraser, Abdul H. Fauq, Hilary A. Lookingbill, Kirk A. Findlay, Tawnya E. Smith, Patrick A. Lewis, Daniel C. McLendon, Rong Wang, Todd E. Golde	2000	92
20	Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation Molecular Neurodegeneration ·Aoife P. Kiely, Helen Ling, Yasmine T. Asi, Eleanna Kara, Christos Proukakis, Anthony H.V. Schapira, Huw R. Morris, Helen C. Roberts, Steven Lubbe, Patricia Limousin, Patrick A. Lewis, Andrew J. Lees, Niall Quinn, John Hardy, Seth Love, Tamás Révész, Henry Houlden, Janice L. Holton	2015	90

About Patrick A. Lewis

Patrick A. Lewis is a scholar working on Neurology, Molecular Biology, Physiology, Cellular and Molecular Neuroscience and Cell Biology, having authored 130 papers that have together received 6.2k indexed citations. Recurring topics across this work include Parkinson's Disease Mechanisms and Treatments (61 papers), Alzheimer's disease research and treatments (21 papers), Cellular transport and secretion (16 papers), Neurological diseases and metabolism (14 papers), Genetic Neurodegenerative Diseases (13 papers), Lysosomal Storage Disorders Research (12 papers), Nuclear Receptors and Signaling (11 papers) and Neurological disorders and treatments (9 papers). The work is most often cited by research in Neurology (3.4k citations), Neurology (964 citations), Cellular and Molecular Neuroscience (1.4k citations), Physiology (1.8k citations) and Cell Biology (964 citations). Patrick A. Lewis has collaborated with scholars based in United Kingdom, United States and Italy. Frequent co-authors include John Hardy, Mark Cookson, Claudia Manzoni, Elisa Greggio, Alexandra Beilina, Nicholas Wood, Andrew J. Lees, Andrew Singleton, Rina Bandopadhyay and Shushant Jain. Their work appears in journals such as Neurobiology of Disease, FEBS Journal, Journal of Neurochemistry, Molecular Neurodegeneration and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Patrick A. Lewis

Impact in

Papers in i

In The Last Decade

Patrick A. Lewis

Patrick A. Lewis's Hit Papers

Peers

Countries citing papers authored by Patrick A. Lewis

Fields of papers citing papers by Patrick A. Lewis

All Works

About Patrick A. Lewis

Explore authors with similar magnitude of impact

Papers in